Psychiatry and Clinical Neurosciences
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Comorbid substance use disorder in schizophrenia: A selective overview of neurobiological and cognitive underpinnings
Psychiatry and Clinical Neurosciences - Tập 67 Số 6 - Trang 367-383 - 2013
Although individuals with schizophrenia show a lifetime prevalence of 50% for
suffering from a comorbid substance use disorder, substance abuse usually
represents an exclusion criterion for studies on schizophrenia. This implies
that surprisingly little is known about a large group of patients who are
particularly difficult to treat. The aim of the present work is to provide a
brief and non‐exhaus...
Regional cerebral blood flow abnormalities in late‐life depression:Relation to refractoriness and chronification
Psychiatry and Clinical Neurosciences - Tập 52 Số 1 - Trang 97-105 - 1998
Abstract We examined patterns of regional cerebral blood flow (rCBF)
abnormalities in 18 patients with major depressive disorder in late life using
single photon emission computed tomography (SPECT) and
(99mTc‐hexamethyl‐propylenamine oxime (99mTc‐HMPAO). Compared with 13
age‐matched controls, relative rCBF was significantly decreased bilaterally in
the anterior cingulate gyrus, the prefrontal cor...
Glutamate hypothesis in schizophrenia
Psychiatry and Clinical Neurosciences - Tập 73 Số 5 - Trang 204-215 - 2019
Schizophrenia is a chronic and severe psychiatric disorder that has profound
impact on an individual’s life and on society. Thus, developing more effective
therapeutic interventions is essential. Over the past quarter‐century, an
abundance of evidence from pharmacologic challenges, post‐mortem studies, brain
imaging, and genetic studies supports the role of glutamatergic dysregulation in
the patho...
Brain‐derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions
Psychiatry and Clinical Neurosciences - Tập 64 Số 4 - Trang 341-357 - 2010
Mood disorders, such as major depressive disorder (MDD) and bipolar disorder
(BPD), are the most prevalent psychiatric conditions, and are also among the
most severe and debilitating. However, the precise neurobiology underlying these
disorders is currently unknown. One way to combat these disorders is to discover
novel biomarkers for them. The development of such biomarkers will aid both in
the d...
Validity of the J apanese version of the REM S leep B ehavior D isorder (RBD ) Screening Questionnaire for detecting probable RBD in the general population
Psychiatry and Clinical Neurosciences - Tập 69 Số 8 - Trang 477-482 - 2015
AimsIn order to evaluate the validity of the REM Sleep Behavior Disorder (RBD)
Screening Questionnaire (RBDSQ) as a screening tool for RBD in a general
population setting, we conducted a validation study using residents of a rural
community.MethodsWe sent questionnaires that included the RBDSQ to 2631 eligible
adult residents in the town of Daisen, Japan.ResultsOf those residents, 1572
participant...
Prevalence and incidence of schizophrenia among national health insurance enrollees in Taiwan, 1996–2001
Psychiatry and Clinical Neurosciences - Tập 58 Số 6 - Trang 611-618 - 2004
Abstract As many as 96% of all residents of Taiwan have been enrolled in the
National Health Insurance (NHI) program since 1996. The NHI database was used to
examine the prevalence and incidence of schizoprenia. The National Health
Research Institute provided a database of 200 432 random subjects, about 1% of
the population, for study. By means of exclusion criteria, a random sample of
136 045 su...
Prevalence of insomnia in various psychiatric diagnostic categories
Psychiatry and Clinical Neurosciences - Tập 56 Số 3 - Trang 239-240 - 2002
Abstract Sixty percent of 536 new referrals to a psychiatric clinic at a general
hospital complained of insomnia. Prevalence was high in all psychiatric
categories, especially in physiologic disorders, somatoform disorders and mood
disorders, followed by epilepsy. Complaints of difficulty in falling asleep were
high in the physiologic and somatoform disorder groups. Complaints of nocturnal
awakeni...
Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel‐based morphometry
Psychiatry and Clinical Neurosciences - Tập 63 Số 4 - Trang 563-568 - 2009
Aims: Repeated exposure to heroin, a typical opiate, causes neuronal adaptation
and may result in anatomical changes in specific brain regions, particularly the
frontal and limbic cortices. The volume changes of gray matter (GM) of these
brain regions, however, have not been identified in heroin addiction.Methods:
Using structural magnetic resonance imaging and an optimized voxel‐based
morphomet...
Resting state default‐mode network connectivity in early depression using a seed region‐of‐interest analysis: Decreased connectivity with caudate nucleus
Psychiatry and Clinical Neurosciences - Tập 63 Số 6 - Trang 754-761 - 2009
Aim: Reports on resting brain activity in healthy controls have described a
default‐mode network (DMN) and important differences in DMN connectivity have
emerged for several psychiatric conditions. No study to date, however, has
investigated resting‐state DMN in relatively early depression before years of
medication treatment. The objective of the present study was, therefore, to
investigate the ...
Cross‐cultural adaptation and psychometric properties of the Social Capital Questionnaire for Adolescent Students among preadolescents and adolescents in Japan
Psychiatry and Clinical Neurosciences - Tập 73 Số 9 - Trang 601-602 - 2019
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