Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel‐based morphometry

Psychiatry and Clinical Neurosciences - Tập 63 Số 4 - Trang 563-568 - 2009
Haihong Liu1, Yihui Hao2, Yoshio Kaneko3, Xuan Ouyang2, Yan Zhang2, Lin Xu4,2, Zhimin Xue2, Zhening Liu2
1Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan, China
2Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan,
3Yale University School of Medicine, New Haven, Connecticut, USA.
4Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology of Chinese Academy of Science, Kuming, Yunnan, China and

Tóm tắt

Aims:  Repeated exposure to heroin, a typical opiate, causes neuronal adaptation and may result in anatomical changes in specific brain regions, particularly the frontal and limbic cortices. The volume changes of gray matter (GM) of these brain regions, however, have not been identified in heroin addiction.

Methods:  Using structural magnetic resonance imaging and an optimized voxel‐based morphometry approach, the GM volume difference between 15 Chinese heroin‐dependent and 15 healthy subjects was tested.

Results:  Compared to healthy subjects, the heroin‐dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices.

Conclusion:  Frontal and cingulate atrophy may be involved in the neuropathology of heroin dependence.

Từ khóa


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Thông tin xuất bản

Psychiatry and Clinical Neurosciences

Tập 63 Số 4

563-568

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