Prostate
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Extracellular Hsp90 mediates an NF‐κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment
Prostate - Tập 74 Số 4 - Trang 395-407 - 2014
BACKGROUNDThe tumor microenvironment (TME) plays an essential role in supporting
and promoting tumor growth and progression. An inflammatory stroma is a
widespread hallmark of the prostate TME, and prostate tumors are known to
co‐evolve with their reactive stroma. Cancer‐associated fibroblasts (CAFs)
within the reactive stroma play a salient role in secreting cytokines that
contribute to this infl...
Chemical demonstration of nuclear androgen receptor following affinity chromatography with immobilized ligands
Prostate - Tập 10 Số 3 - Trang 207-222 - 1987
AbstractWith increasing purification of the androgen receptor from nuclei of rat
ventral prostate, a receptor‐like protein could be demonstrated by chemical
staining with silver nitrate. After sonication and digestion of nuclei with
micrococcal nuclease, the solubilized receptor was applied to a column of Matrex
Gel Green A and eluted with a linear gradient of 0‐2 M NaCl. Characterized by
specific...
Inhibitors of apoptosis proteins in prostate cancer cell lines
Prostate - Tập 51 Số 2 - Trang 133-140 - 2002
AbstractBACKGROUNDThe caspases are the central executioners of apoptosis. The
inhibitors of apoptosis proteins (IAPs) are a family of recently described
caspase inhibitors. We hypothesised that tumor resistance to apoptosis could be
due in part to IAP expression.METHODSThe expression of NAIP, cIAP‐1, cIAP‐2,
XIAP, and survivin was investigated in the prostate cancer cell lines LNCaP,
PC3, and DU14...
Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells
Prostate - Tập 67 Số 2 - Trang 125-134 - 2007
AbstractBACKGROUNDThe androgen receptor (AR) mediates the biological responses
of androgens in the prostate gland. In prostate cancer, this pathway is often
deregulated and causes an uncontrolled proliferation.METHODSThe current study
focuses on the effects of an inhibition of protein kinase CK2 on the AR‐mediated
transcription in LNCaP prostate cancer cells. We used chemical inhibitors of CK2
as ...
Characterization of peripheral benzodiazepine receptors in rat prostatic adenocarcinoma
Prostate - Tập 24 Số 5 - Trang 269-278 - 1994
AbstractUsing PK 11195, a high affinity ligand for peripheral benzodiazepine
receptors (PBZr), binding sites in isolated mitochondrial (m‐fraction) and
microsomal fractions (p‐fraction) from R‐3327 Dunning AT‐1 tumors, ventral and
dorsolateral prostate were studied. Binding of PK 11195 in both m‐ and
p‐fractions from AT‐1 tumors, but only in m‐fraction from ventral and
dorsolateral prostate, was s...
Transrectal ultrasound in the diagnosis of prostate cancer: Location, echogenicity, histopathology, and staging
Prostate - Tập 7 Số 2 - Trang 117-129 - 1985
AbstractAdenocarcinoma of the prostate produces specific ultrasonic findings
that can be used in diagnosis. We have examined 211 patients using transrectal
ultrasound in both the sagittal and axial planes. Thirty‐three carcinomas were
detected, and 31 histologically confirmed; 24 by needle biopsy, six by
transurethral resection, one by total prostatectomy, and two by the
demonstration of distant m...
Familial factors affecting prostatic cancer risk and plasma sex‐steroid levels
Prostate - Tập 6 Số 2 - Trang 121-128 - 1985
AbstractWhether familial factors affect the frequency of prostatic cancer and
the plasma content of sex‐steroids was investigated. Brothers (n = 257) of
probands (n = 150) diagnosed with prostatic cancer before age 62 years had a
fourfold higher risk for developing the disease than men in the general
population in the State of Utah and their brothers‐in‐law (n = 202). Familial
factors markedly aff...
Growth inhibition of human prostate tumor cells by an agonist of gonadotrophin‐releasing hormone
Prostate - Tập 26 Số 4 - Trang 179-188 - 1995
AbstractThe effect of [D‐Leu6, des‐Gly‐NH210, Proethylamide9]‐GnRH, leuprolide,
was determined for the human primary prostate tumor cell line ALVA‐31 by in
vitro mitogenic assays. Prostate tumor cell proliferation was inhibited up to
50% by leuprolide. Inhibition was not observed in parallel cultures treated with
other low molecular weight bioactive peptides. The incorporation and metabolic
reduct...
The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection
Prostate - Tập 71 Số 6 - Trang 575-587 - 2011
AbstractBACKGROUNDAGR2 is a member of the endoplasmatic reticulum protein
disulphide isomerase gene family implicated in tumor metastasis. Its expression
pattern, function, and utility as a marker remains to be further
investigated.METHODSUsing real‐time RT‐PCR and immunohistochemistry, changes of
expression in different tumor stages were explored in microdissected tumor
samples. AGR2 transcript l...
Expression of Foxa transcription factors in the developing and adult murine prostate
Prostate - Tập 62 Số 4 - Trang 339-352 - 2005
AbstractBackgroundThe Foxa family (a1, a2, and a3) of proteins are transcription
factors that are central to endodermal development. Recently, Foxa1 has been
shown to regulate the transcription of several murine and human prostate
specific genes involved in differentiated function by interacting with DNA
promoter sequences and androgen receptors. Currently, the developmental
expression pattern of ...
Tổng số: 80
- 1
- 2
- 3
- 4
- 5
- 6
- 8