Prostate

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Extracellular Hsp90 mediates an NF‐κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment
Prostate - Tập 74 Số 4 - Trang 395-407 - 2014
JE Bohonowych, MW Hance, KD Nolan, Michael DeFee, C. W. PARSONS, JS Isaacs
BACKGROUNDThe tumor microenvironment (TME) plays an essential role in supporting and promoting tumor growth and progression. An inflammatory stroma is a widespread hallmark of the prostate TME, and prostate tumors are known to co‐evolve with their reactive stroma. Cancer‐associated fibroblasts (CAFs) within the reactive stroma play a salient role in secre...... hiện toàn bộ
Chemical demonstration of nuclear androgen receptor following affinity chromatography with immobilized ligands
Prostate - Tập 10 Số 3 - Trang 207-222 - 1987
Bernardo Rocco, Paul S. Rennie, M To, Robert Snoek, Yvonne A. Lefebvre, Elizabeth J. Golsteyn
AbstractWith increasing purification of the androgen receptor from nuclei of rat ventral prostate, a receptor‐like protein could be demonstrated by chemical staining with silver nitrate. After sonication and digestion of nuclei with micrococcal nuclease, the solubilized receptor was applied to a column of Matrex Gel Green A and eluted with a linear gradient of 0‐2 ...... hiện toàn bộ
Inhibitors of apoptosis proteins in prostate cancer cell lines
Prostate - Tập 51 Số 2 - Trang 133-140 - 2002
Kevin McEleny, J. M. Fitzpatrick, Ronan Coffey, Amanda O’Neill, John M. Fitzpatrick
AbstractBACKGROUNDThe caspases are the central executioners of apoptosis. The inhibitors of apoptosis proteins (IAPs) are a family of recently described caspase inhibitors. We hypothesised that tumor resistance to apoptosis could be due in part to IAP expression.METHODS... hiện toàn bộ
Inhibition of protein kinase CK2 leads to a modulation of androgen receptor dependent transcription in prostate cancer cells
Prostate - Tập 67 Số 2 - Trang 125-134 - 2007
Claudia Götz, Christa Bachmann, Mathias Montenarh
AbstractBACKGROUNDThe androgen receptor (AR) mediates the biological responses of androgens in the prostate gland. In prostate cancer, this pathway is often deregulated and causes an uncontrolled proliferation.METHODSThe current study focuses on the effects of an inhib...... hiện toàn bộ
Characterization of peripheral benzodiazepine receptors in rat prostatic adenocarcinoma
Prostate - Tập 24 Số 5 - Trang 269-278 - 1994
Satish Batra, Jan Alenfall
AbstractUsing PK 11195, a high affinity ligand for peripheral benzodiazepine receptors (PBZr), binding sites in isolated mitochondrial (m‐fraction) and microsomal fractions (p‐fraction) from R‐3327 Dunning AT‐1 tumors, ventral and dorsolateral prostate were studied. Binding of PK 11195 in both m‐ and p‐fractions from AT‐1 tumors, but only in m‐fraction from ventral...... hiện toàn bộ
Transrectal ultrasound in the diagnosis of prostate cancer: Location, echogenicity, histopathology, and staging
Prostate - Tập 7 Số 2 - Trang 117-129 - 1985
F Lee, R D McLeary, G H Kumasaka, Gil S. Borlaza, W Straub, Jerry M. Gray, T. R. Meadows, M. Hugh Solomon, Theresa A. McHugh, Richard M. Wolf
AbstractAdenocarcinoma of the prostate produces specific ultrasonic findings that can be used in diagnosis. We have examined 211 patients using transrectal ultrasound in both the sagittal and axial planes. Thirty‐three carcinomas were detected, and 31 histologically confirmed; 24 by needle biopsy, six by transurethral resection, one by total prostatectomy, and two ...... hiện toàn bộ
Familial factors affecting prostatic cancer risk and plasma sex‐steroid levels
Prostate - Tập 6 Số 2 - Trang 121-128 - 1985
A.W. Meikle, Joseph A. Smith, Dee W. West
AbstractWhether familial factors affect the frequency of prostatic cancer and the plasma content of sex‐steroids was investigated. Brothers (n = 257) of probands (n = 150) diagnosed with prostatic cancer before age 62 years had a fourfold higher risk for developing the disease than men in the general population in the State of Utah and their brothers‐in‐law (n = 20...... hiện toàn bộ
Growth inhibition of human prostate tumor cells by an agonist of gonadotrophin‐releasing hormone
Prostate - Tập 26 Số 4 - Trang 179-188 - 1995
Stephen M. Loop, Christine A. Gorder, Suzanne M. Lewis, Joseph H. Saiers, Rolf Drivdahl, Richard C. Ostenson
AbstractThe effect of [D‐Leu6, des‐Gly‐NH210, Proethylamide9]‐GnRH, leuprolide, was determined for the human primary prostate tumor cell line ALVA‐31 by in vitro mitogenic assays. Prostate tumor cell proliferation was inhibited up to 50% by leuprolide. Inhibition was not observed in...... hiện toàn bộ
The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection
Prostate - Tập 71 Số 6 - Trang 575-587 - 2011
Hui Bu, Stefanie Bormann, Georg Schäfer, Wolfgang Horninger, Petra Massoner, Antje Neeb, Vinoth‐Kumar Lakshmanan, Danilo Maddalo, Andrea Nestl, Holger Sültmann, Andrew C.B. Cato, Helmut Klocker
AbstractBACKGROUNDAGR2 is a member of the endoplasmatic reticulum protein disulphide isomerase gene family implicated in tumor metastasis. Its expression pattern, function, and utility as a marker remains to be further investigated.METHODSUsing real‐time RT‐PCR and imm...... hiện toàn bộ
Expression of Foxa transcription factors in the developing and adult murine prostate
Prostate - Tập 62 Số 4 - Trang 339-352 - 2005
Janni Mirosevich, Nan Gao, Robert J. Matusik
AbstractBackgroundThe Foxa family (a1, a2, and a3) of proteins are transcription factors that are central to endodermal development. Recently, Foxa1 has been shown to regulate the transcription of several murine and human prostate specific genes involved in differentiated function by interacting with DNA promoter sequences and and...... hiện toàn bộ
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