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Molecular mechanisms of stress resistance of the photosynthetic apparatus
Pleiades Publishing Ltd - Tập 1 - Trang 185-205 - 2007
V. D. Kreslavski, R. Carpentier, V. V. Klimov, N. Murata, S. I. Allakhverdiev
The mechanisms of action of environmental stress-inducing factors on the photosynthetic apparatus (PA) of plants are considered. The basic targets for stress produced by heat, cold, salinity, osmotic imbalance, and high irradiance are analyzed. It is suggested that stress factors have an influence on the composition of thylakoid membranes and inhibit photosynthetic processes. However, recent studi...... hiện toàn bộ
Immunocytochemical identification of serotoninergic neurons in planaria Girardia tigrina
Pleiades Publishing Ltd - Tập 11 - Trang 68-76 - 2017
N. D. Kreshchenko
Flatworms occupy an important position among simple organisms, which were first in the evolution having bilateral symmetry and centralized nervous system. This paper provides evidence of the presence of a biogenic amine serotonin in free-living flatworms planarians Girardia tigrina (Turbellaria, Platyhelminthes). Using immunohistochemical method, fluorescence and confocal laser scanning microscopy...... hiện toàn bộ
Characterization of synaptic dysfunction in an in vitro corticostriatal model system of Huntington’s disease
Pleiades Publishing Ltd - Tập 7 - Trang 192-202 - 2013
D. N. Artamonov, V. V. Korzhova, J. Wu, P. D. Rybalchenko, K. Im, V. A. Krasnoborova, O. L. Vlasova, I. B. Bezprozvanny
Huntington’s disease (HD) is an autosomal-dominant inherited neurodegenerative disease resulting from expanded amino acid (CAG) repeat in the gene that encodes protein huntingtin (Htt). HD remains incurable for now. A lot of evidence implicates aberrant synaptic connection between cortical and striatal neurons, a key component of HD pathophysilogy, which also leads to cognitive decline and motor d...... hiện toàn bộ
Platelet Integrin αIIbβ3: Mechanisms of Activation and Clustering; Involvement into the Formation of the Thrombus Heterogeneous Structure
Pleiades Publishing Ltd - Tập 13 - Trang 97-110 - 2019
V. N. Kaneva, A. A. Martyanov, D. S. Morozova, M. A. Panteleev, A. N. Sveshnikova
Glycoproteins IIb-IIIa (GPIIb-IIIa), also known as αIIbβ3 integrins, are key platelet adhesion receptors. These molecules are the most abundant (over 10 000 copies per cell) transmembrane receptors playing a crucial role in thrombus formation by promoting platelet aggregation. Integrins need to undergo activation and transit to high-affinity state for their ligands – fibrinogen, fibrin, and von Wi...... hiện toàn bộ
Interaction of liposomes bearing a lipophilic doxorubicin prodrug with tumor cells
Pleiades Publishing Ltd - Tập 7 - Trang 12-20 - 2013
N. R. Kuznetsova, E. V. Svirshchevskaya, I. V. Skripnik, E. N. Zarudnaya, A. N. Benke, G. P. Gaenko, Yu. G. Molotkovskii, E. L. Vodovozova
When used as nanosized carriers, liposomes enable targeted delivery and decrease systemic toxicity of antitumor agents significantly. However, slow unloading of liposomes inside cells diminishes the treatment efficiency. The problem could be overcome by the adoption of lipophilic prodrugs tailored for incorporation into lipid bilayer of liposomes. We prepared liposomes of egg yolk phosphatidylchol...... hiện toàn bộ
Stabilization of NADH dehydrogenase in mitochondria by adenosine phosphates
Pleiades Publishing Ltd - Tập 8 - Trang 206-211 - 2014
M. S. Frolova, N. L. Vekshin
It is known that one of the reasons leading to the development of neuroligical disorders, such as Parkinson’s disease, is the damage of the mitochondrial NADH dehydrogenase. We suggest that it happens when NADH dehydrogenase loses connection with its coenzyme flavine mononucleotide (FMN) in the active center. This process is blocked by the enzyme substrate NADH or by the reaction product NAD. In t...... hiện toàn bộ
Comparison of N-acetyl-L-cysteine and L-cysteine in respect to their transmembrane fluxes
Pleiades Publishing Ltd - Tập 3 - Trang 157-162 - 2009
D. Yildiz, M. Arik, Y. Cakir, Z. Civi
The objective of the present study was to compare cysteine and N-acetyl-L-cysteine in respect to their transmembrane fluxes and find out which one is a better available precursor for the cells and thus better supports the intracellular glutathione synthesis. Cysteine can directly participate in glutathione synthesis, whereas N-acetyl-L-cysteine must be first deacetylated before its incorporation t...... hiện toàn bộ
Membranotropic action of pharmacological agents
Pleiades Publishing Ltd - Tập 3 - Trang 340-340 - 2009
A. I. Vislobokov, Yu. D. Ignatov, K. N. Melnikov
Rat liver mitochondria impairments under acute carbon tetrachloride-induced intoxication. Effects of melatonin
Pleiades Publishing Ltd - Tập 4 - Trang 187-195 - 2010
Y. Z. Maksimchik, I. K. Dremza, E. A. Lapshina, V. T. Cheshchevik, E. Ju. Sudnikovich, S. V. Zabrodskaya, I. B. Zavodnik
The aim of the present work was to investigate the mechanisms of oxidative damage of rat liver mitochondria in vitro, under hypochlorous acid (HOCl)-induced oxidative stress, and in vivo, under acute carbon tetrachloride-induced intoxication in rats. Hypochlorous acid (50–300 μM), the main inflammatory agent, inhibited liver mitochondria respiratory activity and caused uncoupling in the respirator...... hiện toàn bộ
Mathematical Model of Electron Transfer and Formation of Reactive Oxygen Species in Mitochondrial Complex II
Pleiades Publishing Ltd - - 2020
N. I. Markevich, M. H. Galimova, L. N. Markevich
The main goal of this work was a quantitative analysis of the kinetics of the formation of reactive oxygen species (ROS) by complex II of the mitochondrial respiratory chain. For this purpose, a mathematical model was developed for modeling and experimental studies of changes in mitochondria associated with ROS-induced activation of signaling pathways of cell death (apoptosis, necrosis, and necrop...... hiện toàn bộ
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