Pituitary
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Bioactivity and Glycosylation of Circulating Prolactin in Various Physiological and Pathological Conditions
Pituitary - Tập 2 - Trang 225-231 - 1999
Multiple posttranslational processes modify native PRL and result in the secretion of several PRL isoforms with different bioactivity. Since we observed that serum samples contain non-lactogenic substances able to interfere in Nb2 cell bioassay, in this study we extracted PRL molecules from sera of pregnant and non-pregnant normal adults, fetuses and patients with prolactinoma and evaluated the ab...... hiện toàn bộ
Pituitary metastases: a case series and scoping review
Pituitary - Tập 26 - Trang 538-550 - 2023
To understand the natural history and optimal treatment strategy for pituitary gland metastasis. We performed both a retrospective chart review of patients treated at our institution and a scoping review of the topic. The retrospective review identified seven patients with an average age of 59.6 years. Primary histologies included breast cancer (4), melanoma (1), renal cell carcinoma (1), and sarc...... hiện toàn bộ
Limited effects of growth hormone replacement in patients with GH deficiency during long-term cure of acromegaly
Pituitary - Tập 12 - Trang 339-346 - 2009
The aim of this study was to assess the effects of replacement with recombinant human growth hormone (rhGH) in patients with GH deficiency (GHD) after treatment of acromegaly. Intervention study. Sixteen patients (8 men, age 56 years), treated for acromegaly by surgery and radiotherapy, with an insufficient GH response to insulin-induced hypoglycaemia, were treated with 1 year of rhGH replacement....... hiện toàn bộ
Accuracy of immunoassay and mass spectrometry urinary free cortisol in the diagnosis of Cushing’s syndrome
Pituitary - Tập 19 - Trang 496-502 - 2016
Urinary free cortisol (UFC) determination by highly specific methods as mass spectrometry instead of commercially available antibody-based immunoassays is increasingly recommended. However, clinical comparisons of both analytical approaches in the screening of Cushing’s syndrome (CS) are not available. The aim of this study was to evaluate the diagnostic value of mass spectrometry versus immunoas...... hiện toàn bộ
Lymphocytic hypophysitis with associated thyroiditis in a man with aseptic meningitis
Pituitary - Tập 12 - Trang 375-379 - 2008
Objective Lymphocytic hypophysitis (LH) is a rare chronic inflammatory disorder characterized by lymphocytic infiltration of the pituitary gland commonly affecting women during pregnancy or post-partum period. The pathogenesis remains uncertain, however an autoimmune process is frequently implicated. There is limited data on the occurrence of LH outside the setting of auto...... hiện toàn bộ
Acromegaly is associated with a distinct oral and gut microbiota
Pituitary - Tập 25 - Trang 520-530 - 2022
Our aim was to investigate the changes in the composition of oral and gut microbiota in patients with newly diagnosed acromegaly and their relationship with IGF-1 levels. Oral and fecal samples were collected from patients with newly diagnosed acromegaly without comorbidities and from healthy controls. The composition of the microbiota was analyzed. The general characteristics, oral and stool samp...... hiện toàn bộ
Rathke’s cleft cyst presenting as bilateral abducens nerve palsy
Pituitary - Tập 14 - Trang 395-399 - 2009
We present a patient with a Rathke’s cleft cyst who presented with rapidly progressive bilateral 6th nerve palsy. A 20-year-old woman with a history of cleft palate, hypertension, and hydronephrotic kidneys presented with a one month history of headache, associated with dizziness and diplopia on horizontal gaze. Examination was significant for profound bilateral 6th nerve palsies. Magnetic resonan...... hiện toàn bộ
Differential diagnosis of ACTH-dependent hypercortisolism: imaging versus laboratory
Pituitary - Tập 12 - Trang 294-296 - 2009
Differential diagnosis of ACTH-dependent Cushing’s syndrome often presents major difficulties. Diagnostic troubles are increased by suboptimal specificity of endocrine tests, the rarity of ectopic ACTH secretion and the frequent incidental discovery of pituitary adenomas. A 43-year-old female reported with mild signs and symptoms of hypercortisolism, and initial hormonal tests and results of pitui...... hiện toàn bộ
Systemic illness
Pituitary - Tập 11 - Trang 187-207 - 2008
Systemic illnesses are associated with alterations in the hypothalamic–pituitary–peripheral hormone axes, which represent part of the adaptive response to stressful events and may be influenced by type and severity of illness and/or pharmacological therapy. The pituitary gland responds to an acute stressful event with two secretory patterns: adrenocorticotropin (ACTH), prolactin (PRL) and growth h...... hiện toàn bộ
The pituitary–adrenal axis and body composition
Pituitary - Tập 12 - Trang 105-115 - 2008
The activity of the pituitary–adrenal axis can profoundly impact on body composition. This is dramatically seen in Cushing’s syndrome (CS) but changes in body composition are also implicated in depression and alcoholic pseudocushing’s. The pathophysiological mechanisms underlying these changes remain poorly understood. Changes to body composition in CS include increased fat mass, decreased bone ma...... hiện toàn bộ
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