Pharmacology Research and Perspectives

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Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID‐19
Pharmacology Research and Perspectives - Tập 8 Số 5 - 2020
Paula Maria Heister, Robin N. Poston
AbstractMore than ten million patients worldwide have been diagnosed with coronavirus disease 19 (COVID‐19) to date (WHO situation report, 1st July 2020). There is no vaccine to prevent infection with the causative organism, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), nor a cure. In the struggle to devise potentially useful therapeutics in record ...... hiện toàn bộ
Pharmacological characterization of cebranopadol a novel analgesic acting as mixed nociceptin/orphanin FQ and opioid receptor agonist
Pharmacology Research and Perspectives - Tập 4 Số 4 - 2016
Anna Rizzi, Maria Camilla Cerlesi, Chiara Ruzza, Davide Malfacini, Federica Ferrari, Sara Bianco, Tommaso Costa, Remo Guerrini, Claudio Trapella, Girolamo Calò
AbstractThe aim of the study was to investigate the in vitro and in vivo pharmacological profile of cebranopadol, a novel agonist for opioid and nociceptin/orphanin FQ (N/OFQ) receptors (NOP... hiện toàn bộ
Uricosuric targets of tranilast
Pharmacology Research and Perspectives - Tập 5 Số 2 - Trang e00291 - 2017
Asim K. Mandal, Adriana Mercado, Andria Foster, Kambiz Zandi‐Nejad, David B. Mount
Moderate, chronic ethanol feeding exacerbates carbon tetrachloride–induced hepatic fibrosis via hepatocyte‐specific hypoxia‐inducible factor 1α
Pharmacology Research and Perspectives - Tập 2 Số 5 - 2014
Sagorika Paul, Dian Chiang, Megan R. McMullen, Laura E. Nagy
AbstractThe hypoxia‐sensing transcriptional factor HIF1α is implicated in a variety of hepato‐pathological conditions; however, the contribution of hepatocyte‐derived HIF1α during progressi...... hiện toàn bộ
Extensive protein interactions involving cytochrome P450 3A4: a possible contributor to the formation of a metabolosome
Pharmacology Research and Perspectives - Tập 2 Số 5 - 2014
Ryoichi Fujiwara, Tomoo Itoh
AbstractCytochrome P450 (CYP) 3A4 is a membrane protein that catalyzes hydroxylation of endogenous and exogenous substrates. Protein–protein interaction is a crucial factor that regulates the function of enzymes. However, protein–protein interactions involving human hiện toàn bộ
Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID‐19 patients
Pharmacology Research and Perspectives - Tập 8 Số 4 - 2020
Bruce M. Hendry, Nina Stafford, Ahran Arnold, Arvind Sangwaiya, Vijay Manglam, Stuart D. Rosen, Jayantha Arnold
AbstractWe propose a new hypothesis that the established drug pentoxifylline deserves attention as a potential repurposed therapeutic for COVID‐19. Pentoxifylline is an immunomodulator with anti‐inflammatory properties. It is a nonselective phosphodiesterase inhibitor and through Adenosine A2A Receptor‐mediated pathways reduces tumor necrosis factor alpha, interleu...... hiện toàn bộ
Role of endoplasmic reticulum stress in drug‐induced toxicity
Pharmacology Research and Perspectives - Tập 4 Số 1 - 2016
Fabienne Foufelle, Bernard Fromenty
AbstractDrug‐induced toxicity is a key issue for public health because some side effects can be severe and life‐threatening. These adverse effects can also be a major concern for the pharmaceutical companies since significant toxicity can lead to the interruption of clinical trials, or the withdrawal of the incriminated drugs from the market. Recent studies suggest...... hiện toàn bộ
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