Pathobiology
SCIE-ISI SCOPUS (1938-2023)
1423-0291
1015-2008
Thụy Sĩ
Cơ quản chủ quản: S. Karger AG , KARGER
Lĩnh vực:
Cell BiologyMedicine (miscellaneous)Pathology and Forensic MedicineMolecular Biology
Các bài báo tiêu biểu
The Impact of COVID-19 Disease on Platelets and CoagulationCoronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and freq... ... hiện toàn bộ
Tập 88 Số 1 - Trang 15-27 - 2021
Role of the Tumor Microenvironment in Breast CancerIn recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Various components of the breast cancer microenvironment, such... ... hiện toàn bộ
Tập 82 Số 3-4 - Trang 142-152 - 2015
Reconstructed Human Cornea Produced in vitro by Tissue EngineeringThe aim of the present study was to produce a reconstructed human cornea in vitro by tissue engineering and to characterize the expression of integrins and basement membrane proteins in this reconstructed cornea. Epithelial cells and fibroblasts were isolated from human corneas (limbus or centre) and cultured on plastic substrates in vitro. Reconstructed human corneas were obtained by cult... ... hiện toàn bộ
Tập 67 Số 3 - Trang 140-147 - 1999
Pathobiological Implications of MUC16/CA125 Expression in Intrahepatic Cholangiocarcinoma-Mass Forming Type<i>Objectives:</i> MUC16 carries the peptide epitope CA125, which is well known as a marker of ovarian cancer. High serum levels of MUC16 (CA125) have been reported not only in patients with ovarian cancer but also in patients with liver diseases. We evaluated the expression of MUC16 in intrahepatic cholangiocarcinoma-mass forming type (ICC-MF) tissues. <i>Methods:</i&... ... hiện toàn bộ
Tập 79 Số 2 - Trang 101-106 - 2012
Overexpression of Fatty Acid Synthase in Oesophageal Squamous Cell Dysplasia and Carcinoma<i>Objective:</i> The expression of fatty acid synthase (FAS), an enzyme necessary for de novo fatty acid synthesis, has been examined in several types of tumours so far, but not in oesophageal cancer and dysplasia. <i>Methods:</i> We examined the immunohistochemical reactivity of FAS in 4 normal adult oesophagi, 14 dysplastic oesophageal lesions, and 80 squamous ce... ... hiện toàn bộ
Tập 69 Số 6 - Trang 297-303 - 2001
<i>SOX</i> Gene Expression in Human Osteoarthritic Cartilage<i>Objective:</i> While the developmental role of the SOX transcription factors in fetal chondrocyte differentiation is well documented, much less is known about the expression of SOX family members in normal and osteoarthritic adult cartilage. Therefore, the aim of the present study was to present a thorough analysis of <i>SOX</i> gene expression in normal and oste... ... hiện toàn bộ
Tập 75 Số 3 - Trang 195-199 - 2008
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic ComplicationsChitinase 3 like-1 (CHI3L1) is a chitinase-like protein member of family 18 chitinases, expressed in innate immune cells and involved in endothelial dysfunction and tissue remodelling. Since CHI3L1 is highly expressed in a variety of inflammatory diseases of infectious and non-infectious aetiology, it is recognised as a non-invasive prognostic biomarker for inflammation. A variety of studi... ... hiện toàn bộ
Tập 83 Số 5 - Trang 228-242 - 2016
Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose<b><i>Objectives:</i></b> Although intensive therapy for type 2 diabetes (T2D) prevents microvascular complications, 10% of well-controlled T2D patients develop microangiopathy. Therefore, the identification of risk markers for microvascular complications in well-controlled T2D patients is important. Recent studies have demonstrated that high-dose glucose induces ne... ... hiện toàn bộ
Tập 83 Số 5 - Trang 243-251 - 2016
The Role of Micro-CT in 3D Histology Imaging<b><i>Objectives:</i></b> 3D histology tissue modeling is a useful analytical technique for understanding anatomy and disease at the cellular level. However, the current accuracy of 3D histology technology is largely unknown, and errors, misalignment and missing information are common in 3D tissue reconstruction. We used micro-CT imaging technology to better underst... ... hiện toàn bộ
Tập 83 Số 2-3 - Trang 140-147 - 2016
Increased Risk of Atherosclerosis in Patients with SarcoidosisSarcoidosis is a systemic granulomatous disease of unknown etiology. Recent studies demonstrated that its pathogenesis is related with enhanced oxidative stress (protein carbonylation and lipid peroxidation) and alterations in the circulating lipid profile. Alterations of lipid metabolism (including the reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1 concentr... ... hiện toàn bộ
Tập 84 Số 5 - Trang 258-263 - 2017