Pathobiology
SCIE-ISI SCOPUS (1938-2025)
1423-0291
1015-2008
Thụy Sĩ
Cơ quản chủ quản: S. Karger AG , KARGER
Lĩnh vực:
Cell BiologyMedicine (miscellaneous)Pathology and Forensic MedicineMolecular Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
The Impact of COVID-19 Disease on Platelets and Coagulation
Tập 88 Số 1 - Trang 15-27 - 2021
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients
develop a severe proinflammatory state which can be associated with a unique
coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19
infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen)
degradation products. This is associated with systemic hypercoagulability and
frequent ven...
Role of the Tumor Microenvironment in Breast Cancer
Tập 82 Số 3-4 - Trang 142-152 - 2015
In recent years, it has been shown that breast cancer consists not only of
neoplastic cells, but also of significant alterations in the surrounding stroma
or tumor microenvironment. These alterations are now recognized as a critical
element for breast cancer development and progression, as well as potential
therapeutic targets. Various components of the breast cancer microenvironment,
such as supp...
Reconstructed Human Cornea Produced in vitro by Tissue Engineering
Tập 67 Số 3 - Trang 140-147 - 1999
The aim of the present study was to produce a reconstructed human cornea in
vitro by tissue engineering and to characterize the expression of integrins and
basement membrane proteins in this reconstructed cornea. Epithelial cells and
fibroblasts were isolated from human corneas (limbus or centre) and cultured on
plastic substrates in vitro. Reconstructed human corneas were obtained by
culturing ep...
Pathobiological Implications of MUC16/CA125 Expression in Intrahepatic Cholangiocarcinoma-Mass Forming Type
Tập 79 Số 2 - Trang 101-106 - 2012
Objectives: MUC16 carries the peptide epitope CA125, which is well known
as a marker of ovarian cancer. High serum levels of MUC16 (CA125) have been
reported not only in patients with ovarian cancer but also in patients with
liver diseases. We evaluated the expression of MUC16 in intrahepatic
cholangiocarcinoma-mass forming type (ICC-MF) tissues. Methods: We
examined the expression o...
Overexpression of Fatty Acid Synthase in Oesophageal Squamous Cell Dysplasia and Carcinoma
Tập 69 Số 6 - Trang 297-303 - 2001
Objective: The expression of fatty acid synthase (FAS), an enzyme
necessary for de novo fatty acid synthesis, has been examined in several types
of tumours so far, but not in oesophageal cancer and dysplasia. Methods:
We examined the immunohistochemical reactivity of FAS in 4 normal adult
oesophagi, 14 dysplastic oesophageal lesions, and 80 squamous cell carcinomas
and 6 cases with 4...
<i>SOX</i> Gene Expression in Human Osteoarthritic Cartilage
Tập 75 Số 3 - Trang 195-199 - 2008
Objective: While the developmental role of the SOX transcription factors
in fetal chondrocyte differentiation is well documented, much less is known
about the expression of SOX family members in normal and osteoarthritic adult
cartilage. Therefore, the aim of the present study was to present a thorough
analysis of SOX gene expression in normal and osteoarthritic human adult
cartilage...
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic Complications
Tập 83 Số 5 - Trang 228-242 - 2016
Chitinase 3 like-1 (CHI3L1) is a chitinase-like protein member of family 18
chitinases, expressed in innate immune cells and involved in endothelial
dysfunction and tissue remodelling. Since CHI3L1 is highly expressed in a
variety of inflammatory diseases of infectious and non-infectious aetiology, it
is recognised as a non-invasive prognostic biomarker for inflammation. A variety
of studies revea...
Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose
Tập 83 Số 5 - Trang 243-251 - 2016
Objectives: Although intensive therapy for type 2 diabetes (T2D)
prevents microvascular complications, 10% of well-controlled T2D patients
develop microangiopathy. Therefore, the identification of risk markers for
microvascular complications in well-controlled T2D patients is important. Recent
studies have demonstrated that high-dose glucose induces neutrophil
extracellular trap (NET...
The Role of Micro-CT in 3D Histology Imaging
Tập 83 Số 2-3 - Trang 140-147 - 2016
Objectives: 3D histology tissue modeling is a useful analytical
technique for understanding anatomy and disease at the cellular level. However,
the current accuracy of 3D histology technology is largely unknown, and errors,
misalignment and missing information are common in 3D tissue reconstruction. We
used micro-CT imaging technology to better understand these issues and the
relatio...
Increased Risk of Atherosclerosis in Patients with Sarcoidosis
Tập 84 Số 5 - Trang 258-263 - 2017
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Recent
studies demonstrated that its pathogenesis is related with enhanced oxidative
stress (protein carbonylation and lipid peroxidation) and alterations in the
circulating lipid profile. Alterations of lipid metabolism (including the
reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1
concentrations) ...