Pathobiology

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Long-Term NO<sub>2</sub> Exposure Induces Pulmonary Inflammation and Progressive Development of Airflow Obstruction in C57BL/6 Mice: A Mouse Model for Chronic Obstructive Pulmonary Disease?
Pathobiology - Tập 70 Số 5 - Trang 284-286 - 2002
Michael Wegmann, Harald Renz, Udo Herz
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, development of emphysema and irreversible airway obstruction. Macrophages, neutrophils and CD8+ T cells and their products have been shown to play an important role in the initiation and maintenance of these processes. In contrast, the mechanisms underlying COPD pathogenesis still remain u...... hiện toàn bộ
Microbiome: A Supportive or a Leading Actor in Lung Cancer?
Pathobiology - Tập 88 Số 2 - Trang 198-207 - 2021
Diana Martins, Fernando Mendes, Fernando Schmitt
Lung cancer is still the leading cause of cancer death worldwide. Despite the major diagnostic and therapeutic innovations, the effect on mortality has been modest and the overall survival is still poor. Better understanding of the pathology of these tumors is necessary in order to develop personalized therapeutic strategies in lung cancer patients. Human microbiome has been associated wit...... hiện toàn bộ
Overexpression of Fatty Acid Synthase in Oesophageal Squamous Cell Dysplasia and Carcinoma
Pathobiology - Tập 69 Số 6 - Trang 297-303 - 2001
Tsuyoshi Nemoto, Shinya Terashima, Michihiko Kogure, ユタカ ホシノ, Takashi Kusakabe, Toshimitsu Suzuki, Mitsukazu Gotoh
<i>Objective:</i> The expression of fatty acid synthase (FAS), an enzyme necessary for de novo fatty acid synthesis, has been examined in several types of tumours so far, but not in oesophageal cancer and dysplasia. <i>Methods:</i> We examined the immunohistochemical reactivity of FAS in 4 normal adult oesophagi, 14 dysplastic oesophageal lesions, and 80 squamous ce...... hiện toàn bộ
Role of the Tumor Microenvironment in Breast Cancer
Pathobiology - Tập 82 Số 3-4 - Trang 142-152 - 2015
Savas D. Soysal, Alexandar Tzankov, Simone Muenst
In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Various components of the breast cancer microenvironment, such...... hiện toàn bộ
Increased Risk of Atherosclerosis in Patients with Sarcoidosis
Pathobiology - Tập 84 Số 5 - Trang 258-263 - 2017
Elena Bargagli, Elisabetta Rosi, Massimo Pistolesi, Federico Lavorini, Luca Voltolini, Paola Rottoli
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Recent studies demonstrated that its pathogenesis is related with enhanced oxidative stress (protein carbonylation and lipid peroxidation) and alterations in the circulating lipid profile. Alterations of lipid metabolism (including the reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1 concentr...... hiện toàn bộ
Pathobiological Implications of MUC16/CA125 Expression in Intrahepatic Cholangiocarcinoma-Mass Forming Type
Pathobiology - Tập 79 Số 2 - Trang 101-106 - 2012
Michiyo Higashi, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Kazuhiro Tabata, Chihaya Koriyama, Surinder K. Batra, Suguru Yonezawa
<i>Objectives:</i> MUC16 carries the peptide epitope CA125, which is well known as a marker of ovarian cancer. High serum levels of MUC16 (CA125) have been reported not only in patients with ovarian cancer but also in patients with liver diseases. We evaluated the expression of MUC16 in intrahepatic cholangiocarcinoma-mass forming type (ICC-MF) tissues. <i>Methods:</i&...... hiện toàn bộ
Platelet-Derived Growth Factor Regulates Breast Cancer Progression via β-Catenin Expression
Pathobiology - Tập 78 Số 5 - Trang 253-260 - 2011
Yuhki Yokoyama, Seiji Mori, Yoshinosuke Hamada, Miki Hieda, Naomasa Kawaguchi, Mohammed Shaker, Tao Yu, Katsuhide Yoshidome, Masahiko Tsujimoto, Nariaki Matsuura∥
<i>Objective:</i> The knowledge on the association between platelet-derived growth factor (PDGF) signaling and epithelial cancers is scarce, although overexpression of PDGF and PDGF receptors has been reported in some human mesenchymal tumors. Thus, we studied the effect of PDGF on breast cancer cells in vitro and the distribution of PDGF in breast cancer tissues. <i>Meth...... hiện toàn bộ
The Role of Micro-CT in 3D Histology Imaging
Pathobiology - Tập 83 Số 2-3 - Trang 140-147 - 2016
Michael Senter-Zapata, Kunal Patel, Pinky A. Bautista, Molly Griffin, James Michaelson, Yukako Yagi
<b><i>Objectives:</i></b> 3D histology tissue modeling is a useful analytical technique for understanding anatomy and disease at the cellular level. However, the current accuracy of 3D histology technology is largely unknown, and errors, misalignment and missing information are common in 3D tissue reconstruction. We used micro-CT imaging technology to better underst...... hiện toàn bộ
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic Complications
Pathobiology - Tập 83 Số 5 - Trang 228-242 - 2016
Michelino Di Rosa, Lucia Malaguarnera
Chitinase 3 like-1 (CHI3L1) is a chitinase-like protein member of family 18 chitinases, expressed in innate immune cells and involved in endothelial dysfunction and tissue remodelling. Since CHI3L1 is highly expressed in a variety of inflammatory diseases of infectious and non-infectious aetiology, it is recognised as a non-invasive prognostic biomarker for inflammation. A variety of studi...... hiện toàn bộ
<i>SOX</i> Gene Expression in Human Osteoarthritic Cartilage
Pathobiology - Tập 75 Số 3 - Trang 195-199 - 2008
Jochen Haag, Pia Margarethe Gebhard, Thomas Aigner
<i>Objective:</i> While the developmental role of the SOX transcription factors in fetal chondrocyte differentiation is well documented, much less is known about the expression of SOX family members in normal and osteoarthritic adult cartilage. Therefore, the aim of the present study was to present a thorough analysis of <i>SOX</i> gene expression in normal and oste...... hiện toàn bộ
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