Pathobiology

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Platelet-Derived Growth Factor Regulates Breast Cancer Progression via β-Catenin Expression
Pathobiology - Tập 78 Số 5 - Trang 253-260 - 2011
Yuhki Yokoyama, Seiji Mori, Yoshinosuke Hamada, Miki Hieda, Naomasa Kawaguchi, Mohammed Shaker, Tao Yu, Katsuhide Yoshidome, Masahiko Tsujimoto, Nariaki Matsuura∥
<i>Objective:</i> The knowledge on the association between platelet-derived growth factor (PDGF) signaling and epithelial cancers is scarce, although overexpression of PDGF and PDGF receptors has been reported in some human mesenchymal tumors. Thus, we studied the effect of PDGF on breast cancer cells in vitro and the distribution of PDGF in breast cancer tissues. <i>Meth...... hiện toàn bộ
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic Complications
Pathobiology - Tập 83 Số 5 - Trang 228-242 - 2016
Michelino Di Rosa, Lucia Malaguarnera
Chitinase 3 like-1 (CHI3L1) is a chitinase-like protein member of family 18 chitinases, expressed in innate immune cells and involved in endothelial dysfunction and tissue remodelling. Since CHI3L1 is highly expressed in a variety of inflammatory diseases of infectious and non-infectious aetiology, it is recognised as a non-invasive prognostic biomarker for inflammation. A variety of studi...... hiện toàn bộ
Long-Term NO<sub>2</sub> Exposure Induces Pulmonary Inflammation and Progressive Development of Airflow Obstruction in C57BL/6 Mice: A Mouse Model for Chronic Obstructive Pulmonary Disease?
Pathobiology - Tập 70 Số 5 - Trang 284-286 - 2002
Michael Wegmann, Harald Renz, Udo Herz
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, development of emphysema and irreversible airway obstruction. Macrophages, neutrophils and CD8+ T cells and their products have been shown to play an important role in the initiation and maintenance of these processes. In contrast, the mechanisms underlying COPD pathogenesis still remain u...... hiện toàn bộ
<i>SOX</i> Gene Expression in Human Osteoarthritic Cartilage
Pathobiology - Tập 75 Số 3 - Trang 195-199 - 2008
Jochen Haag, Pia Margarethe Gebhard, Thomas Aigner
<i>Objective:</i> While the developmental role of the SOX transcription factors in fetal chondrocyte differentiation is well documented, much less is known about the expression of SOX family members in normal and osteoarthritic adult cartilage. Therefore, the aim of the present study was to present a thorough analysis of <i>SOX</i> gene expression in normal and oste...... hiện toàn bộ
Microbiome: A Supportive or a Leading Actor in Lung Cancer?
Pathobiology - Tập 88 Số 2 - Trang 198-207 - 2021
Diana Martins, Fernando Mendes, Fernando Schmitt
Lung cancer is still the leading cause of cancer death worldwide. Despite the major diagnostic and therapeutic innovations, the effect on mortality has been modest and the overall survival is still poor. Better understanding of the pathology of these tumors is necessary in order to develop personalized therapeutic strategies in lung cancer patients. Human microbiome has been associated wit...... hiện toàn bộ
Overexpression of Fatty Acid Synthase in Oesophageal Squamous Cell Dysplasia and Carcinoma
Pathobiology - Tập 69 Số 6 - Trang 297-303 - 2001
Tsuyoshi Nemoto, Shinya Terashima, Michihiko Kogure, ユタカ ホシノ, Takashi Kusakabe, Toshimitsu Suzuki, Mitsukazu Gotoh
<i>Objective:</i> The expression of fatty acid synthase (FAS), an enzyme necessary for de novo fatty acid synthesis, has been examined in several types of tumours so far, but not in oesophageal cancer and dysplasia. <i>Methods:</i> We examined the immunohistochemical reactivity of FAS in 4 normal adult oesophagi, 14 dysplastic oesophageal lesions, and 80 squamous ce...... hiện toàn bộ
The Impact of COVID-19 Disease on Platelets and Coagulation
Pathobiology - Tập 88 Số 1 - Trang 15-27 - 2021
Geoffrey D. Wool, Jonathan Miller
Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and freq...... hiện toàn bộ
Reconstructed Human Cornea Produced in vitro by Tissue Engineering
Pathobiology - Tập 67 Số 3 - Trang 140-147 - 1999
Lucie Germain, François A. Auger, Eric Grandbois, Rina Guignard, Marcelle Giasson, Hélène Boisjoly, Sylvain L. Guérin
The aim of the present study was to produce a reconstructed human cornea in vitro by tissue engineering and to characterize the expression of integrins and basement membrane proteins in this reconstructed cornea. Epithelial cells and fibroblasts were isolated from human corneas (limbus or centre) and cultured on plastic substrates in vitro. Reconstructed human corneas were obtained by cult...... hiện toàn bộ
Pathobiological Implications of MUC16/CA125 Expression in Intrahepatic Cholangiocarcinoma-Mass Forming Type
Pathobiology - Tập 79 Số 2 - Trang 101-106 - 2012
Michiyo Higashi, Norishige Yamada, Seiya Yokoyama, Sho Kitamoto, Kazuhiro Tabata, Chihaya Koriyama, Surinder K. Batra, Suguru Yonezawa
<i>Objectives:</i> MUC16 carries the peptide epitope CA125, which is well known as a marker of ovarian cancer. High serum levels of MUC16 (CA125) have been reported not only in patients with ovarian cancer but also in patients with liver diseases. We evaluated the expression of MUC16 in intrahepatic cholangiocarcinoma-mass forming type (ICC-MF) tissues. <i>Methods:</i&...... hiện toàn bộ
Circulating Neutrophil Extracellular Trap Levels in Well-Controlled Type 2 Diabetes and Pathway Involved in Their Formation Induced by High-Dose Glucose
Pathobiology - Tập 83 Số 5 - Trang 243-251 - 2016
Arina Miyoshi, Mai Yamada, Haruki Shida, Daigo Nakazawa, Yoshihiro Kusunoki, Akinobu Nakamura, Hideaki Miyoshi, Utano Tomaru, Tatsuya Atsumi, Akihiro Ishizu
<b><i>Objectives:</i></b> Although intensive therapy for type 2 diabetes (T2D) prevents microvascular complications, 10% of well-controlled T2D patients develop microangiopathy. Therefore, the identification of risk markers for microvascular complications in well-controlled T2D patients is important. Recent studies have demonstrated that high-dose glucose induces ne...... hiện toàn bộ
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