Pathobiology
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Long-Term NO<sub>2</sub> Exposure Induces Pulmonary Inflammation and Progressive Development of Airflow Obstruction in C57BL/6 Mice: A Mouse Model for Chronic Obstructive Pulmonary Disease?
Pathobiology - Tập 70 Số 5 - Trang 284-286 - 2002
Chronic obstructive pulmonary disease (COPD) is characterized by chronic
inflammation of the airways, development of emphysema and irreversible airway
obstruction. Macrophages, neutrophils and CD8+ T cells and their products have
been shown to play an important role in the initiation and maintenance of these
processes. In contrast, the mechanisms underlying COPD pathogenesis still remain
uncertain...
Microbiome: A Supportive or a Leading Actor in Lung Cancer?
Pathobiology - Tập 88 Số 2 - Trang 198-207 - 2021
Lung cancer is still the leading cause of cancer death worldwide. Despite the
major diagnostic and therapeutic innovations, the effect on mortality has been
modest and the overall survival is still poor. Better understanding of the
pathology of these tumors is necessary in order to develop personalized
therapeutic strategies in lung cancer patients. Human microbiome has been
associated with normal...
Overexpression of Fatty Acid Synthase in Oesophageal Squamous Cell Dysplasia and Carcinoma
Pathobiology - Tập 69 Số 6 - Trang 297-303 - 2001
Objective: The expression of fatty acid synthase (FAS), an enzyme
necessary for de novo fatty acid synthesis, has been examined in several types
of tumours so far, but not in oesophageal cancer and dysplasia. Methods:
We examined the immunohistochemical reactivity of FAS in 4 normal adult
oesophagi, 14 dysplastic oesophageal lesions, and 80 squamous cell carcinomas
and 6 cases with 4...
Role of the Tumor Microenvironment in Breast Cancer
Pathobiology - Tập 82 Số 3-4 - Trang 142-152 - 2015
In recent years, it has been shown that breast cancer consists not only of
neoplastic cells, but also of significant alterations in the surrounding stroma
or tumor microenvironment. These alterations are now recognized as a critical
element for breast cancer development and progression, as well as potential
therapeutic targets. Various components of the breast cancer microenvironment,
such as supp...
Increased Risk of Atherosclerosis in Patients with Sarcoidosis
Pathobiology - Tập 84 Số 5 - Trang 258-263 - 2017
Sarcoidosis is a systemic granulomatous disease of unknown etiology. Recent
studies demonstrated that its pathogenesis is related with enhanced oxidative
stress (protein carbonylation and lipid peroxidation) and alterations in the
circulating lipid profile. Alterations of lipid metabolism (including the
reduction in high-density lipoprotein cholesterol levels and apolipoprotein A1
concentrations) ...
Pathobiological Implications of MUC16/CA125 Expression in Intrahepatic Cholangiocarcinoma-Mass Forming Type
Pathobiology - Tập 79 Số 2 - Trang 101-106 - 2012
Objectives: MUC16 carries the peptide epitope CA125, which is well known
as a marker of ovarian cancer. High serum levels of MUC16 (CA125) have been
reported not only in patients with ovarian cancer but also in patients with
liver diseases. We evaluated the expression of MUC16 in intrahepatic
cholangiocarcinoma-mass forming type (ICC-MF) tissues. Methods: We
examined the expression o...
Platelet-Derived Growth Factor Regulates Breast Cancer Progression via β-Catenin Expression
Pathobiology - Tập 78 Số 5 - Trang 253-260 - 2011
Objective: The knowledge on the association between platelet-derived
growth factor (PDGF) signaling and epithelial cancers is scarce, although
overexpression of PDGF and PDGF receptors has been reported in some human
mesenchymal tumors. Thus, we studied the effect of PDGF on breast cancer cells
in vitro and the distribution of PDGF in breast cancer tissues. Methods:
The effect of PDG...
The Role of Micro-CT in 3D Histology Imaging
Pathobiology - Tập 83 Số 2-3 - Trang 140-147 - 2016
Objectives: 3D histology tissue modeling is a useful analytical
technique for understanding anatomy and disease at the cellular level. However,
the current accuracy of 3D histology technology is largely unknown, and errors,
misalignment and missing information are common in 3D tissue reconstruction. We
used micro-CT imaging technology to better understand these issues and the
relatio...
Chitinase 3 Like-1: An Emerging Molecule Involved in Diabetes and Diabetic Complications
Pathobiology - Tập 83 Số 5 - Trang 228-242 - 2016
Chitinase 3 like-1 (CHI3L1) is a chitinase-like protein member of family 18
chitinases, expressed in innate immune cells and involved in endothelial
dysfunction and tissue remodelling. Since CHI3L1 is highly expressed in a
variety of inflammatory diseases of infectious and non-infectious aetiology, it
is recognised as a non-invasive prognostic biomarker for inflammation. A variety
of studies revea...
<i>SOX</i> Gene Expression in Human Osteoarthritic Cartilage
Pathobiology - Tập 75 Số 3 - Trang 195-199 - 2008
Objective: While the developmental role of the SOX transcription factors
in fetal chondrocyte differentiation is well documented, much less is known
about the expression of SOX family members in normal and osteoarthritic adult
cartilage. Therefore, the aim of the present study was to present a thorough
analysis of SOX gene expression in normal and osteoarthritic human adult
cartilage...
Tổng số: 13
- 1
- 2