Oxford University Press (OUP)
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Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma
Oxford University Press (OUP) - Tập 5 - Trang 1-14 - 2016
Esophageal squamous cell carcinoma (ESCC) is the sixth most lethal cancer
worldwide and the fourth most lethal cancer in China. Genomic characterization
of tumors, particularly those of different stages, is likely to reveal
additional oncogenic mechanisms. Although copy number alterations and somatic
point mutations associated with the development of ESCC have been identified by
array-based techno...
Connectomics and new approaches for analyzing human brain functional connectivity
Oxford University Press (OUP) - Tập 4 - Trang 1-12 - 2015
Estimating the functional interactions between brain regions and mapping those
connections to corresponding inter-individual differences in cognitive,
behavioral and psychiatric domains are central pursuits for understanding the
human connectome. The number and complexity of functional interactions within
the connectome and the large amounts of data required to study them position
functional conne...
Crowdsourcing genomic analyses of ash and ash dieback – power to the people
Oxford University Press (OUP) - Tập 2 - Trang 1-3 - 2013
Ash dieback is a devastating fungal disease of ash trees that has swept across
Europe and recently reached the UK. This emergent pathogen has received little
study in the past and its effect threatens to overwhelm the ash population. In
response to this we have produced some initial genomics datasets and taken the
unusual step of releasing them to the scientific community for analysis without
firs...
The 3,000 rice genomes project
Oxford University Press (OUP) - Tập 3 - Trang 1-6 - 2014
Rice, Oryza sativa L., is the staple food for half the world’s population. By
2030, the production of rice must increase by at least 25% in order to keep up
with global population growth and demand. Accelerated genetic gains in rice
improvement are needed to mitigate the effects of climate change and loss of
arable land, as well as to ensure a stable global food supply. We resequenced a
core colle...
Quantifying the use of bioresources for promoting their sharing in scientific research
Oxford University Press (OUP) - Tập 2 - Trang 1-8 - 2013
An increasing portion of biomedical research relies on the use of biobanks and
databases. Sharing of such resources is essential for optimizing knowledge
production. A major obstacle for sharing bioresources is the lack of recognition
for the efforts involved in establishing, maintaining and sharing them, due to,
in particular, the absence of adequate tools. Increasing demands on biobanks and
data...
Erratum: SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler
Oxford University Press (OUP) - Tập 4 - Trang 1-1 - 2015
A call for an international network of genomic observatories (GOs)
Oxford University Press (OUP) - Tập 1 Số 1 - 2012
Metabolome of human gut microbiome is predictive of host dysbiosis
Oxford University Press (OUP) - Tập 4 Số 1 - 2015
Deeply sequenced metagenome and metatranscriptome of a biogas-producing microbial community from an agricultural production-scale biogas plant
Oxford University Press (OUP) - Tập 4 - Trang 1-6 - 2015
The production of biogas takes place under anaerobic conditions and involves
microbial decomposition of organic matter. Most of the participating microbes
are still unknown and non-cultivable. Accordingly, shotgun metagenome sequencing
currently is the method of choice to obtain insights into community composition
and the genetic repertoire. Here, we report on the deeply sequenced metagenome
and m...
Building a multi-scaled geospatial temporal ecology database from disparate data sources: fostering open science and data reuse
Oxford University Press (OUP) - Tập 4 - Trang 1-15 - 2015
Although there are considerable site-based data for individual or groups of
ecosystems, these datasets are widely scattered, have different data formats and
conventions, and often have limited accessibility. At the broader scale,
national datasets exist for a large number of geospatial features of land,
water, and air that are needed to fully understand variation among these
ecosystems. However, s...
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