Ovid Technologies (Wolters Kluwer Health)
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Plasma triglyceride and coronary heart disease.
Tập 11 Số 1 - Trang 2-14 - 1991
Although the literature on epidemiological associations between plasma
triglyceride and CHD is not completely consistent, trends do emerge from the
studies described here. First, the majority of observational studies demonstrate
a significant univariate relation, although the results of case-control and
cross-sectional studies are more uniform than those from prospective study
designs. In many but...
Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.
Tập 14 Số 1 - Trang 32-40 - 1994
Atherosclerotic lesions contain relatively large quantities of IgG. We have
previously shown that both human and rabbit sera contain autoantibodies against
epitopes of oxidized (Ox) low-density lipoprotein (LDL) and that LDL isolated
from atherosclerotic lesions contains small amounts of tightly bound IgG.
However, it is not known whether IgG isolated from atherosclerotic lesions
recognizes epitop...
Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.
Tập 14 Số 5 - Trang 753-759 - 1994
To determine if endogenous local levels of nitric oxide (NO) modulate
atherogenesis, we studied the effect of inhibiting NO with NG-nitro-L-arginine
methyl ester (L-NAME) on early neointima formation in cholesterol-fed rabbits.
Male rabbits were fed for 5 weeks with a 0.5% cholesterol diet alone or treated
in addition during the last 4 weeks with L-NAME (12 mg/kg per day SC) via
osmotic minipump. ...
Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.
Tập 11 Số 6 - Trang 1700-1711 - 1991
Oxidized low density lipoprotein (LDL), formed in vivo from presently unknown
reactions, may play a role in atherogenesis. In vitro, transition metals such as
iron and copper will facilitate LDL oxidation, but these metals are unlikely to
exist in free form in normal body fluids. We have explored the possibility that
LDL oxidation may be promoted by heme, a physiologically ubiquitous,
hydrophobic,...
LDL subclass phenotypes and triglyceride metabolism in non-insulin-dependent diabetes.
Tập 12 Số 12 - Trang 1496-1502 - 1992
Plasma low density lipoprotein (LDL) comprises multiple discrete subclasses
differing in size, density, and chemical composition. A common, heritable
phenotype characterized by the predominance of small, dense LDL particles (LDL
subclass phenotype B) is associated with relatively increased concentrations of
plasma triglycerides, reduced levels of high density lipoprotein, and increased
risk of cor...
Change in LDL particle size is associated with change in plasma triglyceride concentration.
Tập 12 Số 11 - Trang 1284-1290 - 1992
Low density lipoprotein (LDL) particle size is inversely associated with plasma
triglyceride concentration in cross-sectional analyses. In the present study,
changes in the LDL particle size of 227 participants of the Framingham Offspring
Study were analyzed longitudinally by nondenaturing gradient gel electrophoresis
at two examinations that were separated by 3-4 years. All subjects had
triglycer...
Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution.
Tập 14 Số 5 - Trang 707-720 - 1994
High-density lipoprotein (HDL) cholesterol (HDL-C) levels are a strong inverse
predictor of atherosclerosis risk, but the physiological determinants of HDL-C
levels are poorly understood. We selected 57 human subjects (30 women and 27
men) with a broad range of HDL-C levels and performed turnover studies of
apolipoprotein (apo)A-I and apoA-II, the two major apolipoproteins of HDL, to
measure the f...
Mechanical properties of model atherosclerotic lesion lipid pools.
Tập 14 Số 2 - Trang 230-234 - 1994
Structural analysis of atherosclerotic coronary arteries has suggested that
stress concentrations are associated with plaque rupture and that these stress
concentrations are critically dependent on the geometry and mechanical
properties of the fibrous cap and lipid pool. Recent clinical trials of
lipid-lowering therapy have shown a significant reduction in cardiac events
associated with plaque rup...
Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation.
Tập 14 Số 5 - Trang 746-752 - 1994
We examined whether prostaglandin (PG) H2, as an endothelium-dependent
contracting factor, or the disturbed production of endothelium-derived relaxing
factor, impairs endothelium-dependent relaxation and whether long-term
inhibition of nitric oxide (NO) synthesis aggravates atherosclerosis in
hypercholesterolemic rabbits. Male New Zealand White rabbits were fed one of the
following diets: (1) stan...
Effect of hepatic lipase on LDL in normal men and those with coronary artery disease.
Tập 13 Số 2 - Trang 147-153 - 1993
Hepatic triglyceride lipase (HL) is thought to play a role in the formation of
low density lipoproteins (LDLs) from small very low density lipoproteins (VLDLs)
and intermediate density lipoproteins (IDLs). To analyze the possible
physiological role of HL in determining LDL buoyancy, size, and chemical
composition, HL activity and LDL were studied in 21 patients with coronary
artery disease (CAD) a...