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Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.
Tập 5 Số 3 - Trang 293-302 - 1985
Fluid velocities were measured by laser Doppler velocimetry under conditions of
pulsatile flow in a scale model of the human carotid bifurcation. Flow velocity
and wall shear stress at five axial and four circumferential positions were
compared with intimal plaque thickness at corresponding locations in carotid
bifurcations obtained from cadavers. Velocities and wall shear stresses during
diastole...
Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.
Tập 6 Số 2 - Trang 131-138 - 1986
The cellular composition of human atherosclerotic plaques was analyzed by
immunologic techniques. Plaques were removed from the internal carotid artery
during surgery, and a panel of monoclonal antibodies was used to identify cell
types. Macrophages stained by Anti-Leu-M3 were found throughout the plaque,
particularly in the lipid core region, where 60% of the cells reacted with this
antibody. T c...
Molecular modeling of protein-glycosaminoglycan interactions.
Tập 9 Số 1 - Trang 21-32 - 1989
Forty-nine regions in 21 proteins were identified as potential heparin-binding
sites based on the sequence organizations of their basic and nonbasic residues.
Twelve known heparin-binding sequences in vitronectin, apolipoproteins E and
B-100, and platelet factor 4 were used to formulate two search strings for
identifying potential heparin-binding regions in other proteins. Consensus
sequences for ...
"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.
Tập 10 Số 4 - Trang 493-496 - 1990
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.
Tập 4 Số 4 - Trang 323-340 - 1984
Morphologic studies resulting from events that occur during the development of
the lesions of atherosclerosis were studied in chronic, diet-induced
hypercholesterolemia in a series of nonhuman primates. Within 12 days of
hypercholesterolemia in Macaca nemestrina, monocytes became adherent to the
surface of the endothelium. These monocytes appeared to migrate
subendothelially, accumulate lipid, and...
Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.
Tập 4 Số 4 - Trang 357-364 - 1984
Our purpose was to determine whether the action of oxidative free radicals
released by endothelial cells and vascular smooth muscle cells grown in culture
could be responsible for certain modifications to low density lipoprotein (LDL).
In these experiments we showed that after a 48-hour incubation with human
umbilical vein endothelial cells or bovine aortic smooth muscle cells, human
LDL: 1) becam...
Regulation of differentiated properties and proliferation of arterial smooth muscle cells.
Tập 10 Số 6 - Trang 966-990 - 1990
Lipoprotein oxidation and lipoprotein-induced cytotoxicity.
Tập 3 Số 3 - Trang 215-222 - 1983
The results of this study indicate that when human VLDL or LDL is prepared under
conditions allowing oxidation, such oxidation renders the molecular complexes
highly toxic to human skin fibroblasts growing in culture. The cytotoxicity can
be predicted by assaying for the presence of thiobarbituric acid-reacting
substances on the lipoprotein. However, malondialdehyde, which reacts with
thiobarbitur...
Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.
Tập 10 Số 3 - Trang 336-349 - 1990
Antisera and monoclonal antibodies generated against autologous
malondialdehyde-conjugated low density lipoprotein (MDA-LDL), 4-hydroxynonenal
conjugated LDL (4-HNE-LDL), and the protein fragments of apoprotein B resulting
from the copper oxidation of LDL, as well as antibodies against apoprotein B,
were used to immunostain atherosclerotic lesions of varying severity from
Watanabe heritable hyperl...
Enhanced macrophage degradation of biologically modified low density lipoprotein.
Tập 3 Số 2 - Trang 149-159 - 1983
Low density lipoprotein (LDL) conditioned by incubation in the presence of
rabbit aortic or human umbilical vein endothelial cells (endothelial
cell-modified LDL) was degraded by macrophages three to five times more rapidly
than LDL incubated in the absence of cells (control LDL). This enhanced
degradation occurred mostly via a high affinity, saturable pathway related to
the pathway for macrophage...