Ovid Technologies (Wolters Kluwer Health)
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Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress.Fluid velocities were measured by laser Doppler velocimetry under conditions of pulsatile flow in a scale model of the human carotid bifurcation. Flow velocity and wall shear stress at five axial and four circumferential positions were compared with intimal plaque thickness at corresponding locations in carotid bifurcations obtained from cadavers. Velocities and wall shear stresses during ... ...
Tập 5 Số 3 - Trang 293-302 - 1985
Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque.The cellular composition of human atherosclerotic plaques was analyzed by immunologic techniques. Plaques were removed from the internal carotid artery during surgery, and a panel of monoclonal antibodies was used to identify cell types. Macrophages stained by Anti-Leu-M3 were found throughout the plaque, particularly in the lipid core region, where 60% of the cells reacted with this antib... ...
Tập 6 Số 2 - Trang 131-138 - 1986
Molecular modeling of protein-glycosaminoglycan interactions.Forty-nine regions in 21 proteins were identified as potential heparin-binding sites based on the sequence organizations of their basic and nonbasic residues. Twelve known heparin-binding sequences in vitronectin, apolipoproteins E and B-100, and platelet factor 4 were used to formulate two search strings for identifying potential heparin-binding regions in other proteins. Consensus sequen... ...
Tập 9 Số 1 - Trang 21-32 - 1989
"Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes.
Tập 10 Số 4 - Trang 493-496 - 1990
Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.Morphologic studies resulting from events that occur during the development of the lesions of atherosclerosis were studied in chronic, diet-induced hypercholesterolemia in a series of nonhuman primates. Within 12 days of hypercholesterolemia in Macaca nemestrina, monocytes became adherent to the surface of the endothelium. These monocytes appeared to migrate subendothelially, accumulate li... ...
Tập 4 Số 4 - Trang 323-340 - 1984
Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.Our purpose was to determine whether the action of oxidative free radicals released by endothelial cells and vascular smooth muscle cells grown in culture could be responsible for certain modifications to low density lipoprotein (LDL). In these experiments we showed that after a 48-hour incubation with human umbilical vein endothelial cells or bovine aortic smooth muscle cells, human LDL: ... ...
Tập 4 Số 4 - Trang 357-364 - 1984
Regulation of differentiated properties and proliferation of arterial smooth muscle cells.
Tập 10 Số 6 - Trang 966-990 - 1990
Lipoprotein oxidation and lipoprotein-induced cytotoxicity.The results of this study indicate that when human VLDL or LDL is prepared under conditions allowing oxidation, such oxidation renders the molecular complexes highly toxic to human skin fibroblasts growing in culture. The cytotoxicity can be predicted by assaying for the presence of thiobarbituric acid-reacting substances on the lipoprotein. However, malondialdehyde, which reacts with thio... ...
Tập 3 Số 3 - Trang 215-222 - 1983
Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.Antisera and monoclonal antibodies generated against autologous malondialdehyde-conjugated low density lipoprotein (MDA-LDL), 4-hydroxynonenal conjugated LDL (4-HNE-LDL), and the protein fragments of apoprotein B resulting from the copper oxidation of LDL, as well as antibodies against apoprotein B, were used to immunostain atherosclerotic lesions of varying severity from Watanabe heritabl... ...
Tập 10 Số 3 - Trang 336-349 - 1990
Enhanced macrophage degradation of biologically modified low density lipoprotein.Low density lipoprotein (LDL) conditioned by incubation in the presence of rabbit aortic or human umbilical vein endothelial cells (endothelial cell-modified LDL) was degraded by macrophages three to five times more rapidly than LDL incubated in the absence of cells (control LDL). This enhanced degradation occurred mostly via a high affinity, saturable pathway related to the pathway for ma... ...
Tập 3 Số 2 - Trang 149-159 - 1983