Oncology

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Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer
Oncology - Tập 98 Số 3 - Trang 179-185 - 2020
Ruth Sacks, Jennie Y. Law, Hong Zhu, Muhammad Shaalan Beg, David E. Gerber, Baran D. Sumer, Larry L. Myers, John M. Truelson, Lucien Nedzi, David J. Sher, Randall Hughes, Saad A. Khan
Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear. Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Recurrence time and metastatic sites in HPV+ HNSCC (Group 1) were compared to patients with HPV-negative/unknown ca... hiện toàn bộ
Clinical and Biological Prognostic Factors in 179 Cases with Sinonasal Carcinoma Treated in the Italian Piedmont Region
Oncology - Tập 76 Số 4 - Trang 262-269 - 2009
Mario Airoldi, Massimiliano Garzaro, Guido Valente, Carlo Mamo, Antonella Bena, Carlo Giordano, Giancarlo Pecorari, P. Gabriele, Anna Maria Gabriele, Fabio Beatrice
Objectives: In spite of aggressive surgery and high-dose radiotherapy, the long-term survival of patients with sinonasal cancer remains disappointing. In this paper, we report data from 179 consecutive cases treated in the Italian Piedmont region between 1996 and 2000 according to a fixed protocol. Methods: Clinical and pathological data and the following biological parameters were a... hiện toàn bộ
Sequential Alteration of Proto-Oncogene Expression in Liver, Spleen, Kidney and Brain of Mice Subjected to Whole Body Irradiation
Oncology - Tập 53 Số 5 - Trang 412-416 - 1996
Yasuhiro Ogawa, Toshiji Saibara, M Terashima, Masafumi Ono, Norihiko Hamada, Akihito Nishioka, T Inomata, Saburo Onishi, Shōji Yoshida, Harumichi Seguchi
Combination of Low-Dose Gemcitabine and Recombinant Quail Vascular Endothelial Growth Factor Receptor-2 as a Vaccine Induces Synergistic Antitumor Activities
Oncology - Tập 69 Số 1 - Trang 81-87 - 2005
Jianmei Hou, Jiyan Liu, Yang Li, Xia Zhao, Ling Tian, Zhenyu Ding, Yanjun Wen, Ting Niu, Fei Xiao, Yanyan Lou, Guang‐Hong Tan, Hongxin Deng, Jiong Li, Jinliang Yang, Yong-Qiu Mao, Bing Kan, Yang Wu, Qiu Li, Yuquan Wei
Vascular endothelial growth factor receptor-2 (VEGFR-2) has been shown to play a major role in inducing the full spectrum of VEGF biological response which is essential for tumor angiogenesis. We have demonstrated that immunotherapy of tumors with a vaccine based on quail homologous VEGFR-2 (qVEGFR) was effective in providing both protective and therapeutic antitumor immunity in several tumor mode... hiện toàn bộ
Overexpression of Cyclin D1 Is Associated with Poor Survival in Epithelial Ovarian Cancer
Oncology - Tập 66 Số 4 - Trang 310-315 - 2004
Federica Barbieri, Paola Lorenzi, Nicola Ragni, Gennaro Schettini, Cristina Bruzzo, F. Pedullá, Angela Alama
Objective: In order to assess the prognostic role of the cell-cycle regulator cyclin D1 in epithelial ovarian cancer, 70 patients have been studied during an observation period of 8 years. Methods: The cyclin D1 protein content was analyzed by Western blotting, and classed as negative, positive and highly positive by densitometric scanning. The relationship between cyclin D1 expressi... hiện toàn bộ
VEGF as a Therapeutic Target in Cancer
Oncology - Tập 69 Số Suppl. 3 - Trang 11-16 - 2005
Napoleone Ferrara
Tumors require nutrients and oxygen in order to grow, and new blood vessels, formed by the process of angiogenesis, provide these substrates. The key mediator of angiogenesis is vascular endothelial growth factor (VEGF), which is induced by many characteristics of tumors, most importantly hypoxia. Therefore, VEGF is an appealing target for anticancer therapeutics. In addition, VEGF is easy to acce... hiện toàn bộ
Analgetic Activity of Calcitonin in Patients with Painful Osteolytic Metastases of Breast Cancer
Oncology - Tập 43 Số 5 - Trang 283-287 - 1986
Anton Roth, Krsto Kolarić
Changing Quality of Life in Patients with Advanced Head and Neck Cancer after Primary Radiotherapy or Chemoradiation
Oncology - Tập 68 Số 4-6 - Trang 405-413 - 2005
Fu‐Min Fang, Wen‐Ling Tsai, Chih‐Yen Chien, Herng‐Chia Chiu, Chong‐Jong Wang, Hui‐Chun Chen, Ching‐Yeh Hsiung
Objective: The purpose of this study was to investigate the longitudinal changes in quality of life (QoL) for patients with advanced stage (stage III or IV) head and neck squamous cell carcinoma (HNSCC) following primary radiotherapy (RT) or concomitant chemoradiotherapy. Methods: From January 2001 to January 2003, 149 patients with advanced HNSCC were enrolled. The data pertaining t... hiện toàn bộ
Inheritance and Testicular Cancer
Oncology - Tập 44 Số 6 - Trang 367-377 - 1987
Klaus‐Peter Dieckmann, Thomas Becker, Dietger Jonas, H Bauer
How to Interpret Serum CA 125 Levels in Patients with Serosal Involvement? A Clinical Dilemma
Oncology - Tập 65 Số 1 - Trang 1-6 - 2003
Alper Sevinç, Celalettin Camcı, Hacı Mehmet Türk, Süleyman Büyükberber
The clinical utility of tumor markers is limited due to their low specificity. CA 125, an ovarian tumor marker, is a sensitive but nonspecific tumor marker used especially in the follow-up of ovarian cancer for monitoring the efficacy of therapy and for early detection of recurrence. The use of the CA 125 serum assay as a single diagnostic tool is restricted by the fact that the antigen to CA 125 ... hiện toàn bộ
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