Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer

Oncology - Tập 98 Số 3 - Trang 179-185 - 2020
Ruth Sacks1, Jennie Y. Law2, Hong Zhu3, Muhammad Shaalan Beg4, David E. Gerber4, Baran D. Sumer5, Larry L. Myers5, John M. Truelson5, Lucien Nedzi6, David J. Sher6, Randall Hughes4, Saad A. Khan4
1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
2Division of Hematology and Oncology, University of Maryland Medical Center, Baltimore, MD, USA
3Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA
4Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas and Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, USA
5Department of Otolaryngology, UT Southwestern Medical Center, Dallas, TX, USA
6Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, USA

Tóm tắt

Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear. Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Recurrence time and metastatic sites in HPV+ HNSCC (Group 1) were compared to patients with HPV-negative/unknown cancers arising in the hypopharynx, larynx, or glottis (Group 2) as well as to patients with HPV-negative/unknown cancers in theoral cavity, oropharynx, hard palate, or tonsil (Group 3). Results: 7/109 (6.4%) patients with HPV+ HNSCC developed DM. The median time to metastases was 11 months. At a median follow-up of 18–25 months, there was no difference in the overall rate of DM for the HPV+ HNSCC group compared to Group 2 (HPV–/unknown) (p = 0.21) and Group 3 (HPV–/unknown) (p = 0.13). There was a significant difference in the rate of DM to the lung in the HPV+ HNSCC group compared to Group 2 (HPV–/unknown) (p = 0.012) and Group 3 (HPV–/unknown) (p = 0.002). Conclusions: There was no observed difference in the time to development of DM between the HPV–/unknown and HPV+ HNSCC groups. However, the HPV+ HNSCC group showed a higher rate of DM to the lung compared to the HPV–/unknown ­HNSCC group (p = 0.002).

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Oncology

Tập 98 Số 3

179-185

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