Oncogene
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Sắp xếp:
Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells
Oncogene - Tập 18 Số 15 - Trang 2413-2421 - 1999
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks
Oncogene - Tập 23 Số 16 - Trang 2934-2949 - 2004
Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1
Oncogene - Tập 22 Số 38 - Trang 5927-5937 - 2003
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1
Oncogene - Tập 23 Số 2 - Trang 359-367 - 2004
Inhibition of RNA polymerase II as a trigger for the p53 response
Oncogene - Tập 18 Số 3 - Trang 583-592 - 1999
Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response
Oncogene - Tập 29 Số 30 - Trang 4317-4329 - 2010
Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration
Oncogene - Tập 25 Số 39 - Trang 5416-5425 - 2006
Synergistic effect between EGF and TGF-β1 in inducing oncogenic properties of intestinal epithelial cells
Oncogene - Tập 27 Số 18 - Trang 2626-2634 - 2008
The tumor microenvironment and its role in promoting tumor growth
Oncogene - Tập 27 Số 45 - Trang 5904-5912 - 2008
C-Myc 5′ untranslated region contains an internal ribosome entry segment
Oncogene - Tập 16 Số 3 - Trang 423-428 - 1998
Translation in eukaryotic cells is generally initiated by ribosome scanning from the 5′ end of the capped mRNA. However, initiation of translation may also occur by a mechanism which is independent of the cap structure and in this case ribosomes are directed to the start codon by an internal ribosome entry segment (IRES). Picornaviruses represent the paradigm for this mechanism, but only a few examples exist which show that this mechanism is used by eukaryotic cells. In this report we show data which demonstrate that the 5′ UTR of the proto-oncogene c-myc contains an IRES. When a dicistronic reporter vector, with c-myc 5′ UTR inserted between the two cistrons, was transfected into both HepG2 and HeLa cells, the translation of the downstream cistron was increased by 50-fold, demonstrating that translational regulation of c-myc is mediated through cap-independent mechanisms. This is the first example of a proto-oncogene regulated in this manner and suggests that aberrant translational regulation of c-myc is likely to play a role in tumorigenesis.
Tổng số: 542
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