The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

Oncogene - Tập 27 Số 28 - Trang 3977-3985 - 2008
El Mustapha Bahassi1, Jerald L. Ovesen2, Ashley L. Riesenberg2, William Z. Bernstein2, Paul Hasty3, Jay A. Tischfield2
1Department of Cell and Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
2University of Cincinnati
3Department of Molecular Medicine/Institute of Biotechnology, the University of Texas Health Science Center at San Antonio, San Antonio, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bahassi EM, Penner CG, Robbins S, Tichy E, Feliciano E, Yin M et al. (2007). The breast cancer susceptibility allele CHEK2*1100delC promotes genomic instability in a knock-in mouse model. Mutat Res 616: 201–209.

Baumann P, Benson FE, West SC . (1996). Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro. Cell 87: 757–766.

Bork P, Blomberg N, Nilges M . (1996). Internal repeats in the BRCA2 protein sequence. Nat Genet 13: 22–23.

Davies A, Masson J, McIlwraith M, Stasiak AZ, Stasiak A, Venkitaraman AR et al. (2001). Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol Cell 7: 273–282.

Donoho G, Brenneman M, Cui TX, Donoviel D, Vogel H, Goodwin EH et al. (2003). Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer 36: 317–331.

Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M et al. (2005). CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434: 598–604.

Mizuta R, LaSalle JM, Cheng HL, Shinohara A, Ogawa H, Copeland N et al. (1997). RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc Natl Acad Sci USA 94: 6927–6932.

Moynahan M, Pierce A, Jasin M . (2001). BRCA2 is required for homology-directed repair of chromosomal breaks. Mol Cell 7: 263–272.

Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL et al. (2002). Insights into DNA recombination from the structure of a RAD51–BRCA2 complex. Nature 420: 287–293.

Ponder BAJ, Day NE, Easton DF, Pharoah PDP . (2000). Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Br J Cancer 83: 1301–1308.

Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C et al. (1997). Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386: 804–810.

Shivji MK, Davies OR, Savill JM, Bates DL, Pellegrini L, Venkitaraman AR . (2006). A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange. Nucleic Acids Res 34: 4000–4011.

Sorensen CS, Hansen LT, Dziegielewski J, Syljuåsen RG, Lundin C, Bartek J et al. (2005). The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol 7: 195–201.

Venkitaraman AR . (2000). The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination? Philos Trans R Soc Lond B Biol Sci 355: 191–198.

Venkitaraman AR . (2002). Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell 2: 171–182.

Welcsh PL, King MC . (2001). BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum Mol Genet 10: 705–713.

Wong AK, Pero R, Ormonde PA, Tavtigian SV, Bartel PL . (1997). RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J Biol Chem 272: 31941–31944.

Xia F, Taghian DG, DeFrank JS, Zeng ZC, Willers H, Iliakis G et al. (2001). Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal non-homologous end-joining. Proc Natl Acad Sci USA 98: 8644–8649.

Yu VP, Koehler M, Steinlein C, Schmid M, Hanakahi LA, van Gool AJ et al. (2000). Gross chromosomal rearrangements and genetic exchange between non-homologous chromosomes following BRCA2 inactivation. Genes Dev 14: 1400–1406.