Nutrition & Metabolism
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Differential effect of obesity on bone mineral density in White, Hispanic and African American women: a cross sectional study
Nutrition & Metabolism - Tập 2 - Trang 1-7 - 2005
Osteoporosis is a major public health problem with low bone mass affecting
nearly half the women aged 50 years or older. Evidence from various studies has
shown that higher body mass index (BMI) is a protective factor for bone mineral
density (BMD). Most of the evidence, however, is from studies with Caucasian
women and it is unclear to what extent ethnicity plays a role in modifying the
effect of...
Comparative effects of oleoyl-estrone and a specific β3-adrenergic agonist (CL316, 243) on the expression of genes involved in energy metabolism of rat white adipose tissue
Nutrition & Metabolism - Tập 7 Số 1 - 2010
Abstract Background The combination of oleoyl-estrone (OE) and a selective
β3-adrenergic agonist (B3A; CL316,243) treatment in rats results in a profound
and rapid wasting of body reserves (lipid). Methods In the present study we
investigated the effect of OE (oral gavage) and/or B3A (subcutaneous constant
infusion) administration for 10 days to overweight male rats, compared with
controls, on thr...
Pharmacological potential of tocotrienols: a review
Nutrition & Metabolism - Tập 11 - Trang 1-22 - 2014
Tocotrienols, members of the vitamin E family, are natural compounds found in a
number of vegetable oils, wheat germ, barley, and certain types of nuts and
grains. Like tocopherols, tocotrienols are also of four types viz. alpha, beta,
gamma and delta. Unlike tocopherols, tocotrienols are unsaturated and possess an
isoprenoid side chain. Tocopherols are lipophilic in nature and are found in
associ...
Targeting energy metabolism in brain cancer: review and hypothesis
Nutrition & Metabolism - Tập 2 - Trang 1-9 - 2005
Malignant brain tumors are a significant health problem in children and adults
and are often unmanageable. As a metabolic disorder involving the dysregulation
of glycolysis and respiration, malignant brain cancer is potentially manageable
through changes in metabolic environment. A radically different approach to
brain cancer management is proposed that combines metabolic control analysis
with the...
Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised
Nutrition & Metabolism - Tập 12 - Trang 1-14 - 2015
Site-1 protease (S1P) is the key enzyme required for activation of the sterol
regulatory element binding proteins (SREBPs) that govern lipid synthesis. While
S1P has been speculated to influence plasma apoB-containing lipoprotein (Blp)
metabolism, there has been little investigative work. LDL receptor (LDLR) is the
major receptor for clearing plasma LDL cholesterol (LDL-c). Proprotein
convertase s...
Consumption of sugar sweetened beverage is associated with incidence of metabolic syndrome in Tehranian children and adolescents
Nutrition & Metabolism - Tập 12 - Trang 1-9 - 2015
Intakes of high sugar-sweetened beverages (SSBs) in adults can escalate risk of
metabolic syndrome (MetS); however, data of longitudinal studies in children and
adolescents are lacking. In this study we assessed consumption of SSBs in
relation to incidence of MetS among children and adolescents during a 3.6 year
follow-up. This study was a population-based longitudinal study, in which 424
subjects...
Bio F1B hamster: a unique animal model with reduced lipoprotein lipase activity to investigate nutrient mediated regulation of lipoprotein metabolism
Nutrition & Metabolism - Tập 4 - Trang 1-13 - 2007
Bio F1B hamster is an inbred hybrid strain that is highly susceptible to
diet-induced atherosclerosis. We previously reported that feeding a high fat
fish oil diet to Bio F1B hamster caused severe hyperlipidaemia. In this study we
compared the effects of various diets in the Bio F1B hamster and the Golden
Syrian hamster, which is an outbred hamster strain to investigate whether
genetic background ...
Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation
Nutrition & Metabolism - Tập 18 - Trang 1-15 - 2021
Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis.
Consumption of hawthorn fruit is believed to be cardio-protective, yet whether
it is able to suppress the TMAO-induced atherosclerosis remains unexplored. The
present study was to investigate the effects of hawthorn fruit extract (HFE) on
TMAO-exacerbated atherogenesis. Five groups of male Apolipoprotein E knock-out
(...
The metabolism and significance of homocysteine in nutrition and health
Nutrition & Metabolism - Tập 14 - Trang 1-12 - 2017
An association between arteriosclerosis and homocysteine (Hcy) was first
demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the
essential amino acid methionine (Met). Hyperhomocysteinemia (HHcy) was
subsequently shown in several age-related pathologies such as osteoporosis,
Alzheimer’s disease, Parkinson’s disease, stroke, and cardiovascular disease
(CVD). Also, Hcy is associ...
Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells
Nutrition & Metabolism - Tập 12 - Trang 1-10 - 2015
Casein-free, gluten-free diets have been reported to mitigate some of the
inflammatory gastrointestinal and behavioral traits associated with autism, but
the mechanism for this palliative effect has not been elucidated. We recently
showed that the opioid peptide beta-casomorphin-7, derived from bovine (bBCM7)
milk, decreases cysteine uptake, lowers levels of the antioxidant glutathione
(GSH) and d...
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