Nucleic Acids Research
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H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations
Nucleic Acids Research - Tập 40 Số W1 - Trang W537-W541 - 2012
Chromatin structure of adenovirus DNA throughout infection
Nucleic Acids Research - Tập 40 Số 6 - Trang 2369-2376 - 2012
CPA: a web-based platform for consensus pathway analysis and interactive visualization
Nucleic Acids Research - Tập 49 Số W1 - Trang W114-W124 - 2021
A mutant RNA pseudoknot that promotes ribosomal frameshifting in mouse mammary tumor virus
Nucleic Acids Research - Tập 25 Số 10 - Trang 1943-1949 - 1997
Complete sequence of an immunoglobulin mRNA using specific priming and the dideoxynucleotide method of RNA sequencing
Nucleic Acids Research - Tập 9 Số 18 - Trang 4485-4494 - 1981
A theophylline responsive riboswitch based on helix slipping controls gene expression in vivo
Nucleic Acids Research - Tập 32 Số 4 - Trang 1610-1614 - 2004
A new nomenclature for the cytoplasmic ribosomal proteins of Saccharomyces cerevisiae
Nucleic Acids Research - Tập 25 Số 24 - Trang 4872-4875 - 1997
Design and synthesis of polyacrylamide-based oligonucleotide supports for use in nucleic acid diagnostics
Nucleic Acids Research - Tập 21 Số 8 - Trang 1819-1826 - 1993
GCNA is a histone binding protein required for spermatogonial stem cell maintenanceAbstract Recycling and de-novo deposition of histones during DNA replication is a critical challenge faced by eukaryotic cells and is coordinated by histone chaperones. Spermatogenesis is highly regulated sophisticated process necessitating not only histone modification but loading of testis specific histone variants. Here, we show that Germ Cell Nuclear Acidic protein (GCNA), a germ cell specific protein in adult mice, can bind histones and purified GCNA exhibits histone chaperone activity. GCNA associates with the DNA replication machinery and supports progression through S-phase in murine undifferentiated spermatogonia (USGs). Whilst GCNA is dispensable for embryonic germ cell development, it is required for the maintenance of the USG pool and for long-term production of sperm. Our work describes the role of a germ cell specific histone chaperone in USGs maintenance in mice. These findings provide a mechanistic basis for the male infertility observed in patients carrying GCNA mutations.
Nucleic Acids Research - Tập 51 Số 10 - Trang 4791-4813 - 2023
Nucleotide sequence of 5S ribosomal RNA fromRhodococcus erythropolis
Nucleic Acids Research - Tập 15 Số 1 - Trang 365-365 - 1987
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