Neuroendocrinology
0028-3835
1423-0194
Thụy Sĩ
Cơ quản chủ quản: S. Karger AG , KARGER
Lĩnh vực:
Endocrinology, Diabetes and MetabolismEndocrinologyCellular and Molecular NeuroscienceEndocrine and Autonomic Systems
Phân tích ảnh hưởng
Thông tin về tạp chí
Neuroendocrinology publishes papers reporting original research in basic and clinical neuroendocrinology. The journal explores the complex interactions between neuronal networks and endocrine glands (in some instances also immune cells) in both central and peripheral nervous systems. Original contributions cover all aspects of the field, from genetic, molecular and cellular neuroendocrinology, physiology, pharmacology, and the neuroanatomy of neuroendocrine systems to neuroendocrine correlates of behaviour, clinical neuroendocrinology and neuroendocrine cancers. Neuroendocrinology is the official journal of the European Neuroendocrine Tumor Society (ENETS) and includes updates on ENETS guidelines. Readers will also benefit from reviews by noted experts, which highlight especially active areas of current research, and special focus editions of topical interest.
Các bài báo tiêu biểu
Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders
Tập 62 Số 4 - Trang 340-347 - 1995
A Role of Ghrelin in Neuroendocrine and Behavioral Responses to Stress in Mice Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, was recently identified in the rat stomach. Previous studies have shown that ghrelin potently increases growth hormone release and food intake. We examined the effects of the gastric peptide ghrelin on anxiety-like behavior in association with the hypothalamic-pituitary-adrenal axis in mice. Both intra-third cerebroventricular and intraperitoneal administration of ghrelin potently and significantly induced anxiogenic activities in the elevated plus maze test. Ghrelin gene expression in the stomach was increased by tail pinch stress as well as by starvation stress. Administration of a corticotropin-releasing hormone (CRH) receptor antagonist significantly inhibited ghrelin-induced anxiogenic effects. Peripherally administered ghrelin significantly increased CRH mRNA, but not urocortin mRNA expression in the hypothalamus. Furthermore, intraperitoneal injection of ghrelin produced a significant dose- dependent increase in serum corticosterone levels. These findings suggest that ghrelin may have a role in mediating neuroendocrine and behavioral responses to stressors and that the stomach could play an important role, not only in the regulation of appetite, but also in the regulation of anxiety.
Tập 74 Số 3 - Trang 143-147 - 2001
Pituitary-Adrenal Activation Following Intrahypothalamic Microinjection of Morphine
Tập 4 Số 6 - Trang 326-332 - 1969
Interactions between Hippocampal Serotonin and the Pituitary-Adrenal Axis in the Septal Driving of Hippocampal Theta-Rhythm
Tập 39 Số 5 - Trang 471-475 - 1984
Neonatal Handling Alters Adrenocortical Negative Feedback Sensitivity and Hippocampal Type II Glucocorticoid Receptor Binding in the Rat
Tập 50 Số 5 - Trang 597-604 - 1989
Analysis of Angiotensin II Receptor Subtypes in Individual Rat Brain Nuclei
Tập 55 Số 5 - Trang 563-573 - 1992
Pineal Hydroxyindole-O-Methyltransferase and Gonadal Responses to Blinding or Continuous Darkness Blocked by Pineal Denervation in the Male Hamster
Tập 8 Số 2 - Trang 81-85 - 1971
The Effect of Anterior Cervical Ganglionectomy on the Seasonal Variation in Prolactin Concentration in Goats
Tập 23 Số 2 - Trang 121-128 - 1977
Seizure Activity Is Increased in Endocrine States Characterized by Decline in Endogenous Levels of the Neurosteroid 3α,5α-THP To examine the role of progesterone (P) and its 5α-reduced metabolite, the neurosteroid 5α-pregnan-3α-ol-20-one (3α,5α-THP), in endogenous variations in ictal activity rats were tested for kainic acid-induced seizures in different hormonal milieu. Corresponding plasma and central P and 3α,5α-THP levels were measured. Cycling Long-Evans rats in estrus and proestrus had seizures of significantly shorter duration and more central and plasma 3α,5α-THP and P than animals in metestrus or diestrus. Females with luteal functioning had seizures of significantly shorter duration and increased central and plasma 3α,5α-THP and P compared to animals that recently had luteal functioning discontinued. Pregnant rats had significantly shorter seizures and greater central and plasma 3α,5α-THP and central P than animals tested 1–2 days postparturition. In all test paradigms, seizure activity was increased in animals that had decreased 3α,5α-THP or P; overall, central 3α,5α-THP was more inversely related to ictal activity than central P or plasma P and 3α,5α-THP. To investigate a causal relationship between 3α,5α-THP and seizures, a 5α-reductase inhibitor, finasteride, or vehicle was administered to pregnant rats. Finasteride administration significantly decreased central and plasma 3α,5α-THP, but had no significant effect on plasma or central P of pregnant rats. Finasteride, but not vehicle administration, to pregnant rats significantly increased seizure duration. These findings support the hypothesis that variations in seizure threshold over endogenous hormonal milieu may be related to endogenous 3α,5α-THP. Of all of the endocrine conditions, seizure durations were greatest in diestrus animals; this group did not experience the lowest or the greatest decrease in 3α,5α-THP concentrations; however, of all of the endocrine conditions, cycling rats experienced the most rapid cycles of 3α,5α-THP variation. This suggests that cycles of endogenous variations in 3α,5α-THP may influence seizure threshold.
Tập 68 Số 4 - Trang 272-280 - 1998