Prothrombin Complex Concentrate for Emergent Reversal of Intracranial Hemorrhage in Patients with Ventricular Assist DevicesNeurocritical Care - Tập 35 - Trang 506-517 - 2021
Grace Y. Lai, Matthew B. Maas, Christopher R. Leong, Eric M. Liotta, Jonathan D. Rich, Duc T. Pham, Esther E. Vorovich, Andrew M. Naidech, Babak S. Jahromi, Matthew B. Potts
Intracranial hemorrhage (ICH) is a devastating complication for patients with
ventricular assist devices (VADs). The safety of emergent anticoagulation
reversal with four-factor prothrombin complex concentrate (PCC) and optimal
timing of anticoagulation resumption are not clear. In addition, lactate
dehydrogenase (LDH) is used as a biomarker for thromboembolic risk, but its
utility in guiding anti... hiện toàn bộ
Intraventricular Nicardipine for Refractory Cerebral Vasospasm after Subarachnoid HemorrhageNeurocritical Care - Tập 8 - Trang 247-252 - 2007
Kelly Goodson, Marc Lapointe, Timothy Monroe, Julio A. Chalela
Delayed ischemic deficit from vasospasm is a leading cause of morbidity and
mortality after aneurysmal subarachnoid hemorrhage. Although several treatment
modalities have been used to reverse the deleterious effects of vasospasm,
alternative therapies are needed, as conventional therapies are often
ineffective or contraindicated. Intrathecal nicardipine has been suggested for
the prevention of vas... hiện toàn bộ
Effect of Interferon-β on Neuroinflammation, Brain Injury and Neurological Outcome After Experimental Subarachnoid HemorrhageNeurocritical Care - Tập 18 Số 1 - Trang 96-105 - 2013
Tiebosch, Ivo A. C. W., Dijkhuizen, Rick M., Cobelens, Pieter M., Bouts, Mark J. R. J., Zwartbol, René, van der Meide, Peter H., van den Bergh, Walter M.
Aneurysmal subarachnoid hemorrhage (SAH) has a poor outcome, particularly
attributed to progressive injury after the initial incident. Several studies
suggest a critical role for inflammation in lesion progression after SAH. Our
goal was to test whether treatment with anti-inflammatory interferon-β, which
has shown promise as a therapeutic agent in experimental ischaemic stroke, can
protect the br... hiện toàn bộ
Hemodynamic, Biochemical, and Ventilatory Parameters are Independently Associated with Outcome after Cardiac ArrestNeurocritical Care - Tập 29 - Trang 69-76 - 2018
Joseph H. Pitcher, John Dziodzio, Joshua Keller, Teresa May, Richard R. Riker, David B. Seder
Hypotension, hyperglycemia, dysoxia, and dyscarbia may contribute to reperfusion
injury, and each is independently associated with poor outcome (PO) after
cardiac arrest. We investigated whether the combined effects of these
physiological derangements are associated with cardiac arrest outcomes. This
institutional review board-approved retrospective cohort study included
consecutive resuscitated c... hiện toàn bộ
Blood Pressure and Spot Sign in Spontaneous Supratentorial Subcortical Intracerebral HemorrhageNeurocritical Care - Tập 37 - Trang 246-254 - 2022
Joseph A. Falcone, Alex Lopez, Dana Stradling, Wengui Yu, Jefferson W. Chen
Spontaneous intracerebral hemorrhage is a potentially devastating cause of brain
injury, often occurring secondary to hypertension. Contrast extravasation on
computed tomography angiography (CTA), known as the spot sign, has been shown to
predict hematoma expansion and worse outcomes. Although hypertension has been
associated with an increased rate of the spot sign being present, the
relationship ... hiện toàn bộ