NeuroImmunoModulation
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<b><i>Schistosoma</i></b> Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1
NeuroImmunoModulation - Tập 20 Số 4 - Trang 233-238 - 2013
Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the
immune response to HTLV-1 infection is polarized to the Th1-type, chronic
helminth infections drive the Th2- and T regulatory-type, and are able to
downregulate the inflammatory response in some autoimmune diseases.
Objective: To evalua...
The Role of Cytokines in the Neuropathology of Stroke and Neurotrauma
NeuroImmunoModulation - Tập 5 Số 3-4 - Trang 143-159 - 1998
Accumulating evidence during the last decade has shown that the CNS can mount a
well-defined inflammatory reaction to a variety of insults including trauma,
ischemia, transplantation, viral infections as well as neurodegeneration. Many
aspects of this centrally derived inflammatory response parallel to some extent
the nature of such a reaction in the periphery. Through the recent application
of mo...
An Age-Related Decline in Interleukin-10 May Contribute to the Increased Expression of Interleukin-6 in Brain of Aged Mice
NeuroImmunoModulation - Tập 9 Số 4 - Trang 183-192 - 2001
Objectives: The DNA-binding activity of nuclear factor ĸB (NFĸB) is
elevated in brain of aged mice, resulting in elevated levels of the inflammatory
cytokine interleukin (IL)-6. The purpose of this study was to determine if in
the brain of aged mice a decrease in the anti-inflammatory cytokine IL-10
contributes to the increase in IL-6. Methods: In initial studies coronal
brain sectio...
Repeated Lipopolysaccharide Stimulation Induces Cellular Senescence in BV2 Cells
NeuroImmunoModulation - Tập 19 Số 2 - Trang 131-136 - 2012
Background and Aim: The dual action of microglia in neurodegenerating
diseases has been controversial for some time. Recent studies indicate that
microglia senescence might be the key determinant. When microglia age, they
function abnormally and fail to respond correctly to stimuli, which eventually
promotes neurodegeneration. Accumulating evidence has shown a close relationship
between inf...
One Hormone, Two Actions: Anti- and Pro-Inflammatory Effects of Glucocorticoids
NeuroImmunoModulation - Tập 22 Số 1-2 - Trang 20-32 - 2015
Glucocorticoids are essential steroid hormones secreted from the adrenal gland
in response to stress. Since their discovery in the 1940s, glucocorticoids have
been widely prescribed to treat inflammatory disorders and hematological
cancers. In the traditional view, glucocorticoids are regarded as
anti-inflammatory molecules; however, emerging evidence suggests that
glucocorticoid actions are more ...
Influence of Chronic Interleukin-2 Infusion and Stressors on Sickness Behaviors and Neurochemical Change in Mice
NeuroImmunoModulation - Tập 11 Số 5 - Trang 341-350 - 2004
Objectives: Major depression is associated with increased circulating
interleukin-2 (IL-2) levels, and IL-2 immunotherapy may provoke depressive
symptoms, leading to the suggestion that this cytokine may contribute to the
evolution of affective disorders. Although depression is a relatively chronic
condition, and immunotherapy involves repeated cytokine administration, animal
studies have t...
Receptor Biology of the Melanocortins, a Family of Neuroimmunomodulatory Peptides
NeuroImmunoModulation - Tập 3 Số 5 - Trang 259-284 - 1996
Chronic Effects of the Sympathetic Nervous System in Inflammatory Models
NeuroImmunoModulation - Tập 30 Số 1 - Trang 113-134 - 2023
The immune system is embedded in a network of regulatory systems to keep
homeostasis in case of an immunologic challenge. Neuroendocrine immunologic
research has revealed several aspects of these interactions over the past
decades, e.g., between the autonomic nervous system and the immune system. This
review will focus on evidence revealing the role of the sympathetic nervous
system (SNS) in chron...
Plasma Aminothiol Compounds, but Not Serum Tumor Necrosis Factor Receptor II and Soluble Receptor for Advanced Glycation End Products, Are Related to the Cognitive Impairment in Alzheimer’s Disease and Mild Cognitive Impairment Patients
NeuroImmunoModulation - Tập 14 Số 3-4 - Trang 163-167 - 2007
Increasing evidence indicates that factors such as oxidative stress, plasma
homocysteine increase and glutathione depletion, elevated pro-inflammatory
cytokines and advanced glycation end products can play a role in Alzheimer’s
disease (AD) pathogenesis. The receptor for advanced glycation end products
(RAGE) is a cell surface receptor that has been implicated in neurodegeneration,
and a soluble i...
Peripheral Neurokinin-1 Receptors Contribute to Kaolin-Induced Acute Monoarthritis in Rats
NeuroImmunoModulation - Tập 22 Số 6 - Trang 373-384 - 2015
Objective: intra-articular co-injection of kaolin with carrageenan
(CGN) in rodents is widely used as an experimental model of arthritis. However,
the ability of kaolin to cause arthritis and related immune responses when
administered alone is unclear. We evaluated the contribution of prostanoids and
sensory C-fibres (and their neuropeptide substance P) to kaolin-induced
inflammation...
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