NeuroImmunoModulation

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<b><i>Schistosoma</i></b> Antigens Downmodulate the in vitro Inflammatory Response in Individuals Infected with Human T Cell Lymphotropic Virus Type 1
NeuroImmunoModulation - Tập 20 Số 4 - Trang 233-238 - 2013
Luciane Mota Lima, Silvane Braga Santos, Ricardo Riccio Oliveira, Luciana Santos Cardoso, Sabrina Oliveira, Alfredo Miranda Góes, Alex Loukas, Edgar M. Carvalho, Maria Pino‐Yanes
Human T cell lymphotropic virus type 1 (HTLV-1) is the causal agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). While the immune response to HTLV-1 infection is polarized to the Th1-type, chronic helminth infections drive the Th2- and T regulatory-type, and are able to downregulate the inflammatory response in some autoimmune diseases. <b><i>Objectiv...... hiện toàn bộ
The Role of Cytokines in the Neuropathology of Stroke and Neurotrauma
NeuroImmunoModulation - Tập 5 Số 3-4 - Trang 143-159 - 1998
G. Feuerstein, Xinkang Wang, Frank C. Barone
Accumulating evidence during the last decade has shown that the CNS can mount a well-defined inflammatory reaction to a variety of insults including trauma, ischemia, transplantation, viral infections as well as neurodegeneration. Many aspects of this centrally derived inflammatory response parallel to some extent the nature of such a reaction in the periphery. Through the recent applicati...... hiện toàn bộ
An Age-Related Decline in Interleukin-10 May Contribute to the Increased Expression of Interleukin-6 in Brain of Aged Mice
NeuroImmunoModulation - Tập 9 Số 4 - Trang 183-192 - 2001
Shi-Ming Ye, Rodney W. Johnson
<i>Objectives:</i> The DNA-binding activity of nuclear factor ĸB (NFĸB) is elevated in brain of aged mice, resulting in elevated levels of the inflammatory cytokine interleukin (IL)-6. The purpose of this study was to determine if in the brain of aged mice a decrease in the anti-inflammatory cytokine IL-10 contributes to the increase in IL-6. <i>Methods:</i> In init...... hiện toàn bộ
Repeated Lipopolysaccharide Stimulation Induces Cellular Senescence in BV2 Cells
NeuroImmunoModulation - Tập 19 Số 2 - Trang 131-136 - 2012
Hongmei Yu, Yanmin Zhao, Xiaoguang Luo, Yu Feng, Yan Ren, Hong Shang, Zhiyi He, Xiaomeng Luo, Shengdi Chen, Xiyin Wang
<i>Background and Aim:</i> The dual action of microglia in neurodegenerating diseases has been controversial for some time. Recent studies indicate that microglia senescence might be the key determinant. When microglia age, they function abnormally and fail to respond correctly to stimuli, which eventually promotes neurodegeneration. Accumulating evidence has shown a close rela...... hiện toàn bộ
One Hormone, Two Actions: Anti- and Pro-Inflammatory Effects of Glucocorticoids
NeuroImmunoModulation - Tập 22 Số 1-2 - Trang 20-32 - 2015
Diana Cruz‐Topete, John A. Cidlowski
Glucocorticoids are essential steroid hormones secreted from the adrenal gland in response to stress. Since their discovery in the 1940s, glucocorticoids have been widely prescribed to treat inflammatory disorders and hematological cancers. In the traditional view, glucocorticoids are regarded as anti-inflammatory molecules; however, emerging evidence suggests that glucocorticoid actions a...... hiện toàn bộ
Influence of Chronic Interleukin-2 Infusion and Stressors on Sickness Behaviors and Neurochemical Change in Mice
NeuroImmunoModulation - Tập 11 Số 5 - Trang 341-350 - 2004
Kerry Sudom, Nicolas P. Turrin, Shawn Hayley, Hymie Anisman
<i>Objectives:</i> Major depression is associated with increased circulating interleukin-2 (IL-2) levels, and IL-2 immunotherapy may provoke depressive symptoms, leading to the suggestion that this cytokine may contribute to the evolution of affective disorders. Although depression is a relatively chronic condition, and immunotherapy involves repeated cytokine administration, a...... hiện toàn bộ
Receptor Biology of the Melanocortins, a Family of Neuroimmunomodulatory Peptides
NeuroImmunoModulation - Tập 3 Số 5 - Trang 259-284 - 1996
Jeffrey B. Tatro
Chronic Effects of the Sympathetic Nervous System in Inflammatory Models
NeuroImmunoModulation - Tập 30 Số 1 - Trang 113-134 - 2023
Georg Pongratz, Rainer H. Straub
The immune system is embedded in a network of regulatory systems to keep homeostasis in case of an immunologic challenge. Neuroendocrine immunologic research has revealed several aspects of these interactions over the past decades, e.g., between the autonomic nervous system and the immune system. This review will focus on evidence revealing the role of the sympathetic nervous system (SNS) ...... hiện toàn bộ
Plasma Aminothiol Compounds, but Not Serum Tumor Necrosis Factor Receptor II and Soluble Receptor for Advanced Glycation End Products, Are Related to the Cognitive Impairment in Alzheimer’s Disease and Mild Cognitive Impairment Patients
NeuroImmunoModulation - Tập 14 Số 3-4 - Trang 163-167 - 2007
Ángel Hernánz, Mónica De la Fuente, Mercedes Navarro, Ana Frank
Increasing evidence indicates that factors such as oxidative stress, plasma homocysteine increase and glutathione depletion, elevated pro-inflammatory cytokines and advanced glycation end products can play a role in Alzheimer’s disease (AD) pathogenesis. The receptor for advanced glycation end products (RAGE) is a cell surface receptor that has been implicated in neurodegeneration, and a s...... hiện toàn bộ
Peripheral Neurokinin-1 Receptors Contribute to Kaolin-Induced Acute Monoarthritis in Rats
NeuroImmunoModulation - Tập 22 Số 6 - Trang 373-384 - 2015
Lívia L. Camargo, Alexandre Denadai‐Souza, Lidia Yshii, Filiphe P.N. Mesquita, António G. Soares, Carla Lima, André Almeida Schenka, Andrew Grant, Elizabeth S. Fernandes, Marcelo N. Muscará, Soraia K.P. Costa
<b><i>Objective:</i></b> intra-articular co-injection of kaolin with carrageenan (CGN) in rodents is widely used as an experimental model of arthritis. However, the ability of kaolin to cause arthritis and related immune responses when administered alone is unclear. We evaluated the contribution of prostanoids and sensory C-fibres (and their neuropeptide substance P...... hiện toàn bộ
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