Nephron

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Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury
Nephron - Tập 137 Số 4 - Trang 268-272 - 2017
Neil A. Hukriede, Andreas Vogt, Mark de Caestecker
The cellular responses that occur following acute kidney injury (AKI) are complex and dynamic, involving multiple cells types and molecular pathways. For this reason, early selection of defined molecular targets for therapeutic intervention is unlikely to be effective in complex in vivo models of AKI, let alone Phase 3 clinical trials in patients with even more complex AKI pathobiology. Ph...... hiện toàn bộ
Urinary Excretion of α<sub>2</sub><sub>u</sub>-Globulin and Albumin by Adult Male Rats following Treatment with Nephrotoxic Agents
Nephron - Tập 28 Số 3 - Trang 133-140 - 1981
Otto W. Neuhaus, Wayne Flory, N. M. Biswas, Charles E. Hollerman
Vasopressin and Diabetes mellitus
Nephron - Tập 87 Số 1 - Trang 8-18 - 2001
Lise Bankir, Pascale Bardoux, Mina Ahloulay
In diabetes mellitus (DM), the urine flow rate is increased, and the fluid turnover in the body is accelerated because of the glucose-induced osmotic diuresis. On the other hand, plasma vasopressin (VP) is elevated in both type 1 and type 2 DM. This elevation seems to be due to a resetting of the osmostat. A high VP level is beneficial in the short term because it limits to some extent the...... hiện toàn bộ
Heme Oxygenase-1 Localization in the Rat Nephron
Nephron - Tập 92 Số 3 - Trang 660-664 - 2002
Michelle Shepard, Prasad Dhulipala, Sunit Kabaria, Nader G. Abraham, Elias A. Lianos
<i>Background/Aims:</i> Renal tubules undergo oxidative injury in various nephropathies. It is unknown whether tubular cells possess mechanisms to attenuate this form of injury. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, may provide such a mechanism by reducing levels of free heme, a prooxidant molecule, and by limiting activity of heme-containing pro...... hiện toàn bộ
Hemolysate Pretreatment Ameliorates Ischemic Acute Renal Injury in Rats
Nephron - Tập 92 Số 2 - Trang 407-413 - 2002
Rika Yoneya, Yoji Nagashima, Kyohei Sakaki, Kiyokazu Hagiwara, Hirobumi Teraoka, Hisashi Ozasa, Saburo Horikawa
Heme oxygenase-1 (HO-1) is an antioxidant enzyme and is believed to protect against oxidative stress-induced tissue injury. Renal ischemia-reperfusion (IR) injury seems at least in part to be caused by the oxidative stress. The aim of this study was to improve the renal IR injury by clinically available means. When littermate hemolysate was intravenously administered into rats, HO-1 was ma...... hiện toàn bộ
Electron Probe Analysis of Tubular Fluid Composition
Nephron - Tập 6 Số 3 - Trang 350-364 - 1969
François M. M. Morel, N. Roinel, C. Le Grimellec
Blockade of Radiocontrast-lnduced Nephrotoxicity by the Endothelin Receptor Antagonist, SB 209670
Nephron - Tập 72 Số 4 - Trang 629-636 - 1996
David P. Brooks, P. Dennis DePalma
Does Paracetamol Cause Urothelial Cancer or Renal Papillary Necrosis?
Nephron - Tập 49 Số 4 - Trang 296-300 - 1988
Margaret McCredie, John H. Stewart
Kidney Involvement in Systemic Lupus erythematosus and Fabry’s Disease
Nephron - Tập 34 Số 3 - Trang 180-184 - 1983
E. Rosenmann, Isaac Kobrin, Ted Cohen
Long-Term Knowledge Retention following Predialysis Psychoeducational Intervention
Nephron - Tập 86 Số 2 - Trang 129-134 - 2000
Gerald M. Devins, David J. Hollomby, Paul E. Barré, Henry Mandin, Kenneth J. Taub, Leendert C. Paul, Ronald D. Guttmann, Yitzchak M. Binik
<i>Background/Aims:</i> Early identification and predialysis psychoeducation are gaining acceptance. Although research supports the immediate value of predialysis interventions, long-term benefits remain unknown. We examined long-term knowledge retention following a psychoeducational intervention. <i>Methods:</i> 47 progressive renal failure patients completed the K...... hiện toàn bộ
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