Nephrology Dialysis Transplantation
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Sắp xếp:
Gadolinium – a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?
Nephrology Dialysis Transplantation - Tập 21 Số 4 - Trang 1104-1108 - 2006
Analyzing hospitalization data: potential limitations of Poisson regression
Nephrology Dialysis Transplantation - Tập 30 Số 8 - Trang 1244-1249 - 2015
Whole body and regional body composition in patients with chronic renal failure
Nephrology Dialysis Transplantation - Tập 11 Số 8 - Trang 1613-1618 - 1996
Hyponatremia and other electrolyte abnormalities in patients receiving immune checkpoint inhibitors Abstract
Background
Hyponatremia due to endocrinopathies such as adrenal insufficiency and hypothyroidism has been reported in patients receiving immune checkpoint inhibitors (ICIs). We determined the risk and predictors of hyponatremia and other electrolyte abnormalities in a ‘real-world’ sample of patients receiving ICIs to treat advanced malignancies.
Methods
This was a retrospective observational study of all patients who received ICIs from a single cancer center between 2011 and 2018. Patients were followed for 12 months after initiation of ICIs or until death. Common Terminology for Cancer Adverse Events version 5.0 criteria were used to grade the severity of hyponatremia and other electrolyte abnormalities. The predictors of severe (Grade 3 or 4) hyponatremia were determined using a multivariable logistic regression model. The etiology of Grade 3 or 4 hyponatremia was determined by chart review.
Results
A total of 2458 patients were included. Their average age was 64 years [standard deviation (SD) 13], 58% were male and 90% were white. In the first year after starting ICIs, 62% experienced hyponatremia (sodium <134 mEq/L) and 136 (6%) experienced severe hyponatremia (<124 mEq/L). Severe hyponatremia occurred on average 164 days (SD 100) after drug initiation. Only nine cases of severe hyponatremia were due to endocrinopathies (0.3% overall incidence). Risk factors for severe hyponatremia included ipilimumab (a cytotoxic T lymphocyte antigen-4 inhibitor) use, diuretic use and non-White race. Other severe electrolyte abnormalities were also commonly observed: severe hypokalemia (potassium <3.0 mEq/L) occurred in 6%, severe hyperkalemia (potassium ≥6.1 mEq/L) occurred in 0.6%, severe hypophosphatemia (phosphorus <2 mg/dL) occurred in 17% and severe hypocalcemia (corrected calcium <7.0 mg/dL) occurred in 0.2%.
Conclusions
Hyponatremia is common in cancer patients receiving ICIs. However, endocrinopathies are an uncommon cause of severe hyponatremia.
Nephrology Dialysis Transplantation - Tập 36 Số 12 - Trang 2241-2247 - 2021
Mutation analyses of Uroplakin II in children with renal tract malformations
Nephrology Dialysis Transplantation - Tập 21 Số 12 - Trang 3415-3421
P-Cadherin is decreased in diabetic glomeruli and in glucose-stimulated podocytes in vivo and in vitro studies
Nephrology Dialysis Transplantation - Tập 20 Số 3 - Trang 524-531 - 2005
Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury
Nephrology Dialysis Transplantation - Tập 15 Số 10 - Trang 1562-1574 - 2000
Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy
Nephrology Dialysis Transplantation - Tập 24 Số 8 - Trang 2378-2383 - 2009
Unilateral multicystic dysplastic kidney: a meta-analysis of observational studies on the incidence, associated urinary tract malformations and the contralateral kidney
Nephrology Dialysis Transplantation - Tập 24 Số 6 - Trang 1810-1818 - 2009
Relative risk versus absolute risk: one cannot be interpreted without the other
Nephrology Dialysis Transplantation - Tập 32 Số suppl_2 - Trang ii13-ii18 - 2017
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