Bacterial evolution of antibiotic hypersensitivityMolecular Systems Biology - Tập 9 Số 1 - 2013
Viktória Lázár, Gajinder Pal Singh, Réka Spohn, István Nagy, Balázs Horváth, Mónika Hrtyan, Róbert Busa‐Fekete, Balázs Bogos, Orsolya Méhi, Bálint Csörgő, György Pósfai, Gábor Fekete, Balázs Szappanos, Balázs Kégl, Balázs Papp, Csaba Pál
The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents. In sharp contrast, very little is known about the frequency and mechanisms underlying collateral sensitivity. In this case, genetic adaptation under antibiotic stress yields enhanced sensitivity to other antibiotics. Using large‐scale laboratory evolu...... hiện toàn bộ
Revisiting biomarker discovery by plasma proteomicsMolecular Systems Biology - Tập 13 Số 9 - 2017
Philipp E. Geyer, Lesca M. Holdt, Daniel Teupser, Matthias Mann
AbstractClinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (<...... hiện toàn bộ
Computational meta'omics for microbial community studiesMolecular Systems Biology - Tập 9 Số 1 - 2013
Nicola Segata, Daniela Boernigen, Timothy L. Tickle, Xochitl C. Morgan, Wendy S. Garrett, Curtis Huttenhower
Complex microbial communities are an integral part of the Earth's ecosystem and of our bodies in health and disease. In the last two decades, culture‐independent approaches have provided new insights into their structure and function, with the exponentially decreasing cost of high‐throughput sequencing resulting in broadly available tools for microbial surveys. However, the field remains f...... hiện toàn bộ
Edgetic perturbation models of human inherited disordersMolecular Systems Biology - Tập 5 Số 1 - 2009
Quan Zhong, Nicolas Simonis, Qianru Li, Benoît Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, K. Venkatesan, Danny Mou, Venus Swearingen, Muhammed A. Yıldırım, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E. Hill, Michael E. Cusick, Marc Vidal