Three serendipitous pathways in E. coli can bypass a block in pyridoxal‐5′‐phosphate synthesisMolecular Systems Biology - Tập 6 Số 1 - 2010
Juhan Kim, Jamie P. Kershner, Yehor Y. Novikov, R. L. Shoemaker, Shelley D. Copley
Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose. Promiscuous reactions can be patched together to form multistep metabolic pathways. Mutations that increase expression or activity of enzymes in such serendipitous pathways...... hiện toàn bộ
Arabidopsis G‐protein interactome reveals connections to cell wall carbohydrates and morphogenesisMolecular Systems Biology - Tập 7 Số 1 - 2011
Karsten Klopffleisch, Nguyen Phan, Kelsey Augustin, Robert S. Bayne, Katherine S. Booker, José Ramón Botella, Nicholas C. Carpita, Tyrell Carr, Jin‐Gui Chen, Thomas Ryan Cooke, Arwen E. Frick-Cheng, Erin J. Friedman, Brandon Fulk, Michael G. Hahn, Kun Jiang, Lucía Jordá, Lydia Linnéa Kruppe, Liu Cheng-gang, Justine Lorek, Maureen C. McCann, Antonio Molina, Etsuko N. Moriyama, M. Shahid Mukhtar, Yashwanti Mudgil, Sivakumar Pattathil, John J. Schwarz, Steven Seta, Matthew Tan, Ulrike Temp, Yuri Trusov, Daisuke Urano, Bastian Welter, Jing Yang, Ralph Panstruga, Joachim F. Uhrig, Alan M. Jones
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collectionMolecular Systems Biology - Tập 2 Số 1 - 2006
Tomoya Baba, Takeshi Ara, Miki Hasegawa, Yuki Takai, Yoshiko Okumura, Miki Baba, Kirill A. Datsenko, Masaru Tomita, Barry L. Wanner, Hirotada Mori
Global microRNA level regulation of EGFR‐driven cell‐cycle protein network in breast cancerMolecular Systems Biology - Tập 8 Số 1 - 2012
Stefan Uhlmann, Heiko Mannsperger, Jitao David Zhang, Emőke-Ágnes Horvát, Christian Schmidt, Moritz Küblbeck, Frauke Henjes, Aoife Ward, Ulrich Tschulena, Katharina A. Zweig, Ulrike Korf, Stefan Wiemann, Özgür Şahin
Bacterial evolution of antibiotic hypersensitivityMolecular Systems Biology - Tập 9 Số 1 - 2013
Viktória Lázár, Gajinder Pal Singh, Réka Spohn, István Nagy, Balázs Horváth, Mónika Hrtyan, Róbert Busa‐Fekete, Balázs Bogos, Orsolya Méhi, Bálint Csörgő, György Pósfai, Gábor Fekete, Balázs Szappanos, Balázs Kégl, Balázs Papp, Csaba Pál
The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents. In sharp contrast, very little is known about the frequency and mechanisms underlying collateral sensitivity. In this case, genetic adaptation under antibiotic stress yields enhanced sensitivity to other antibiotics. Using large‐scale laboratory evolu...... hiện toàn bộ
A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranesMolecular Systems Biology - Tập 7 Số 1 - 2011
Deepak B. Thimiri Govinda Raj, Bart Ghesquière, Arun Kumar Tharkeshwar, Katrijn Coen, Rita Derua, Dieter Vanderschaeghe, Evelien Rysman, Muralidhararao Bagadi, Pieter Baatsen, Bart De Strooper, Etienne Waelkens, Gustaaf Borghs, Nico Callewaert, Johannes V. Swinnen, Kris Gevaert, Wim Annaert