Revisiting biomarker discovery by plasma proteomicsMolecular Systems Biology - Tập 13 Số 9 - 2017
Philipp E. Geyer, Lesca M. Holdt, Daniel Teupser, Matthias Mann
AbstractClinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate. As described in this review, mass spectrometry (<...... hiện toàn bộ
Computational meta'omics for microbial community studiesMolecular Systems Biology - Tập 9 Số 1 - 2013
Nicola Segata, Daniela Boernigen, Timothy L. Tickle, Xochitl C. Morgan, Wendy S. Garrett, Curtis Huttenhower
Complex microbial communities are an integral part of the Earth's ecosystem and of our bodies in health and disease. In the last two decades, culture‐independent approaches have provided new insights into their structure and function, with the exponentially decreasing cost of high‐throughput sequencing resulting in broadly available tools for microbial surveys. However, the field remains f...... hiện toàn bộ
Edgetic perturbation models of human inherited disordersMolecular Systems Biology - Tập 5 Số 1 - 2009
Quan Zhong, Nicolas Simonis, Qianru Li, Benoît Charloteaux, Fabien Heuze, Niels Klitgord, Stanley Tam, Haiyuan Yu, K. Venkatesan, Danny Mou, Venus Swearingen, Muhammed A. Yıldırım, Han Yan, Amélie Dricot, David Szeto, Chenwei Lin, Tong Hao, Changyu Fan, Stuart Milstein, Denis Dupuy, Robert Brasseur, David E. Hill, Michael E. Cusick, Marc Vidal
Three serendipitous pathways in E. coli can bypass a block in pyridoxal‐5′‐phosphate synthesisMolecular Systems Biology - Tập 6 Số 1 - 2010
Juhan Kim, Jamie P. Kershner, Yehor Y. Novikov, R. L. Shoemaker, Shelley D. Copley
Bacterial genomes encode hundreds to thousands of enzymes, most of which are specialized for particular functions. However, most enzymes have inefficient promiscuous activities, as well, that generally serve no purpose. Promiscuous reactions can be patched together to form multistep metabolic pathways. Mutations that increase expression or activity of enzymes in such serendipitous pathways...... hiện toàn bộ
Arabidopsis G‐protein interactome reveals connections to cell wall carbohydrates and morphogenesisMolecular Systems Biology - Tập 7 Số 1 - 2011
Karsten Klopffleisch, Nguyen Phan, Kelsey Augustin, Robert S. Bayne, Katherine S. Booker, José Ramón Botella, Nicholas C. Carpita, Tyrell Carr, Jin‐Gui Chen, Thomas Ryan Cooke, Arwen E. Frick-Cheng, Erin J. Friedman, Brandon Fulk, Michael G. Hahn, Kun Jiang, Lucía Jordá, Lydia Linnéa Kruppe, Liu Cheng-gang, Justine Lorek, Maureen C. McCann, Antonio Molina, Etsuko N. Moriyama, M. Shahid Mukhtar, Yashwanti Mudgil, Sivakumar Pattathil, John J. Schwarz, Steven Seta, Matthew Tan, Ulrike Temp, Yuri Trusov, Daisuke Urano, Bastian Welter, Jing Yang, Ralph Panstruga, Joachim F. Uhrig, Alan M. Jones