Molecular Neurobiology

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Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress
Molecular Neurobiology - Tập 56 Số 8 - Trang 5586-5607 - 2019
Jingdian Zhang, Jiachun Feng, Di Ma, Feng Wang, Yumeng Wang, Chunxiao Li, Xu Wang, Xiaoyang Yin, Ming Zhang, Ruben K. Dagda, Ying Zhang
Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke
Molecular Neurobiology - Tập 55 - Trang 7090-7106 - 2018
Ludmila Belayev, Sung-Ha Hong, Hemant Menghani, Shawn J. Marcell, Andre Obenaus, Raul S. Freitas, Larissa Khoutorova, Veronica Balaszczuk, Bokkyoo Jun, Reinaldo B. Oriá, Nicolas G. Bazan
Docosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA (5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after. Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was in...... hiện toàn bộ
Dual MicroRNA to Cellular Prion Protein Inhibits Propagation of Pathogenic Prion Protein in Cultured Cells
Molecular Neurobiology - Tập 55 Số 3 - Trang 2384-2396 - 2018
Sang Gyun Kang, Chiye Kim, Judd M. Aiken, Han Sang Yoo, Debbie McKenzie
KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice
Molecular Neurobiology - - 2016
Marika Cordaro, Irene Paterniti, Rosalba Siracusa, Daniela Impellizzeri, Emanuela Esposito, Salvatore Cuzzocrea
Autophagy is an intracellular catabolic mechanism for the degradation of cytoplasmic constituents in the autophagosomal–lysosomal pathway. This mechanism plays an important role in homeostasis and it is defective in certain diseases. Preceding studies have revealed that autophagy is developing as an important moderator of pathological responses associated to spinal cord injury (SCI) and plays a cr...... hiện toàn bộ
Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis
Molecular Neurobiology - Tập 53 - Trang 5701-5709 - 2015
Cristiano Noto, Vanessa Kiyomi Ota, Marcos Leite Santoro, Eduardo Sauerbronn Gouvea, Patricia Natalia Silva, Leticia Maria Spindola, Quirino Cordeiro, Rodrigo Affonseca Bressan, Ary Gadelha, Elisa Brietzke, Sintia Iole Belangero, Michael Maes
In schizophrenia, genetic and environmental factors affect neurodevelopment and neuroprogressive trajectory. Altered expression of neuro-immune genes and increased levels of cytokines are observed, especially in patients with comorbid depression. However, it remains unclear whether circulating levels of cytokines and expression of these genes are associated, and how antipsychotic treatments impact...... hiện toàn bộ
Control of Na<sup>+</sup> Spike Backpropagation by Intracellular Signaling in the Pyramidal Neuron Dendrites
Molecular Neurobiology -
Hiroshi Tsubokawa
Co-Administration of Vitamins B12 and D During Pregnancy Have Strong Neuroprotective Effects in Parkinson Disease
Molecular Neurobiology - Tập 60 Số 4 - Trang 1986-1996 - 2023
Khosravi, Faramarz, Mirzaei, Sepideh, Hojati, Vida, Hashemi, Mehrdad, Entezari, Maliheh
Parkinson’s disease (PD) is a common disease whose pathophysiological mechanism is not well understood. Recent research studies have shown that PD patients have low serum levels of vitamins B12 and D. Therefore, in this study, the effects of supplementation with vitamins B12 and D on PD female mice as well as their fetuses were studied. After preparation of female mice and induction of Parkinson’s...... hiện toàn bộ
Chronic Stress- and Sex-Specific Neuromorphological and Functional Changes in Limbic Structures
Molecular Neurobiology - Tập 40 Số 2 - Trang 166-182 - 2009
Katie J. McLaughlin, Sarah E. Baran, Cheryl D. Conrad
Unraveling the Contribution of Serotonergic Polymorphisms, Prefrontal Alpha Asymmetry, and Individual Alpha Peak Frequency to the Emotion-Related Impulsivity Endophenotype
Molecular Neurobiology - Tập 59 - Trang 6062-6075 - 2022
Florian Javelle, Andreas Löw, Wilhelm Bloch, Thomas Hosang, Thomas Jacobsen, Sheri L. Johnson, Alexander Schenk, Philipp Zimmer
The unique contribution of the serotonin transporter-linked polymorphic region (5-HTTLPR), intronic region 2 (STin2), and monoamine oxidase A (MAO-A) genes to individual differences in personality traits has been widely explored, and research has shown that certain forms of these polymorphisms relate to impulsivity and impulsivity-related disorders. Humans showing these traits are also described a...... hiện toàn bộ
Regulation of Survival Motor Neuron Protein by the Nuclear Factor-Kappa B Pathway in Mouse Spinal Cord Motoneurons
Molecular Neurobiology - Tập 55 - Trang 5019-5030 - 2017
Saravanan Arumugam, Stefka Mincheva-Tasheva, Ambika Periyakaruppiah, Sandra de la Fuente, Rosa M. Soler, Ana Garcera
Survival motor neuron (SMN) protein deficiency causes the genetic neuromuscular disorder spinal muscular atrophy (SMA), characterized by spinal cord motoneuron degeneration. Since SMN protein level is critical to disease onset and severity, analysis of the mechanisms involved in SMN stability is one of the central goals of SMA research. Here, we describe the role of several members of the NF-κB pa...... hiện toàn bộ
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