Molecular Neurobiology
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Inhibition of the Receptor for Advanced Glycation End-Products (RAGE) Attenuates Neuroinflammation While Sensitizing Cortical Neurons Towards Death in Experimental Subarachnoid Hemorrhage
Molecular Neurobiology - Tập 54 - Trang 755-767 - 2016
Subarachnoid hemorrhage (SAH) is a threatening and devastating neurological
insult with high mortality and morbidity rates. Despite considerable efforts,
the underlying pathophysiological mechanisms are still poorly understood. The
receptor for advanced glycation end products (RAGE) is a multiligand receptor
that has been implicated in various pathological conditions. We previously
showed that RAG...
Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress
Molecular Neurobiology - Tập 56 Số 8 - Trang 5586-5607 - 2019
Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action
Molecular Neurobiology - Tập 55 - Trang 3755-3774 - 2017
In the present study, upon showing sexual dimorphism in dimethyl fumarate (DMF)
efficacy to moderate the clinical severity of experimental autoimmune
encephalomyelitis (EAE) in Dark Agouti rats, cellular and molecular substrate of
this dimorphism was explored. In rats of both sexes, DMF administration from the
day of immunization attenuated EAE severity, but this effect was more prominent
in males...
Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke
Molecular Neurobiology - Tập 55 - Trang 7090-7106 - 2018
Docosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective
after experimental ischemic stroke. To explore underlying mechanisms, SD rats
underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA
(5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after.
Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1,
2, 3, or 4. BrdU was in...
Dual MicroRNA to Cellular Prion Protein Inhibits Propagation of Pathogenic Prion Protein in Cultured Cells
Molecular Neurobiology - Tập 55 Số 3 - Trang 2384-2396 - 2018
Cyclosporine A and MnTMPyP Alleviate α-Synuclein Expression and Aggregation in Cypermethrin-Induced Parkinsonism
Molecular Neurobiology - Tập 52 - Trang 1619-1628 - 2014
Cypermethrin induces the mitochondrial dysfunction and oxidative damage to the
nigrostriatal dopaminergic neurons leading to Parkinsonism in rats. Despite
α-synuclein aggregation is reported to be critical in Parkinson’s disease, its
role and alliance with the mitochondrial dysfunction and oxidative damage
leading to cypermethrin-induced Parkinsonism have not yet been deciphered. The
present study...
VEGF-A Promotes Both Pro-angiogenic and Neurotrophic Capacities for Nerve Recovery After Compressive Neuropathy in Rats
Molecular Neurobiology - Tập 51 - Trang 240-251 - 2014
Nerve recovery following injury is usually incomplete, leaving functional
deficits. Our aim was to investigate the neural changes in pro-angiogenic,
pro-inflammatory and apoptotic factors during and after chronic nerve
compression (CNC). Nerve function was impaired after CNC and was progressively
restored after nerve decompression, while nerve blood flow was elevated. While
the expression of the p...
JNK Isoforms Are Involved in the Control of Adult Hippocampal Neurogenesis in Mice, Both in Physiological Conditions and in an Experimental Model of Temporal Lobe Epilepsy
Molecular Neurobiology - Tập 56 - Trang 5856-5865 - 2019
Neurogenesis in the adult dentate gyrus (DG) of the hippocampus allows the
continuous generation of new neurons. This cellular process can be disturbed
under specific environmental conditions, such as epileptic seizures; however,
the underlying mechanisms responsible for their control remain largely unknown.
Although different studies have linked the JNK (c-Jun-N-terminal-kinase)
activity with the...
Molecular analysis of the function of the neuronal growth-associated protein GAP-43 by genetic intervention
Molecular Neurobiology - Tập 5 - Trang 131-141 - 1991
GAP-43 is a presynaptic membrane phosphoprotein that has been implicated in both
the development and the modulation of neural connections. The availability of
cDNA clones for GAP-43 makes it possible to examine with greater precision its
role in neuronal outgrowth and physiology. We used Northern blots andin situ
hybridization with GAP-43 antisense RNA probes to show that GAP-43 is expressed
selec...
Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons
Molecular Neurobiology - Tập 53 - Trang 3756-3770 - 2015
Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly.
Mitochondrial dysfunction plays an important role in the pathogenesis of PD.
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a
powerful transcription factor, interacting with multiple transcription factors
and widely involving in the regulation of mitochondrial biogenesis, oxidative
stress, and o...
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