Co-Administration of Vitamins B12 and D During Pregnancy Have Strong Neuroprotective Effects in Parkinson Disease
Tóm tắt
Parkinson’s disease (PD) is a common disease whose pathophysiological mechanism is not well understood. Recent research studies have shown that PD patients have low serum levels of vitamins B12 and D. Therefore, in this study, the effects of supplementation with vitamins B12 and D on PD female mice as well as their fetuses were studied. After preparation of female mice and induction of Parkinson’s by rotenone administration for 19 days, rotarod test was used to confirm PD induction. During this time, supplementations with vitamins B12 and D were performed. On day 19, after confirmation of PD induction, half of the mice were killed and the other half were allowed to mate with males. Viability was measured by the MTT method, and apoptosis and necrosis of cerebellar neurons were measured by flow cytometry. The RT-PCR technique was used to evaluate the relative expressions of the bax, bcl-2, miR-211, and circRNA 0,001,518 genes. Data analysis was performed by the GraphPad Prism V.8 software. Co-administration of vitamins B12 and D resulted in highest viability percentage and greatest reduction in apoptosis and necrosis of cerebellar neurons in the female mice as well as their fetuses compared to the PD females. A decrease in the relative expression of the bax and miR-211 genes and an increase in bcl-2 expression were observed in the cerebellar tissue of PD mice receiving both vitamins. Vitamins B12 and D have neuroprotective effects on PD conditions. Therefore, co-administration of these two vitamins is recommended in PD patients during pregnancy.
Tài liệu tham khảo
citation_journal_title=J Neural Transm; citation_title=Epidemiology of Parkinson’s disease; citation_author=O-B Tysnes, A Storstein; citation_volume=124; citation_issue=8; citation_publication_date=2017; citation_pages=901-905; citation_doi=10.1007/s00702-017-1686-y; citation_id=CR1
Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR (2015) Oxidative stress and Parkinson’s disease. Front Neuroanat 9 (91).
https://doi.org/10.3389/fnana.2015.00091
citation_journal_title=Nutr Neurosci; citation_title=Cellular and molecular mechanisms of antioxidants in Parkinson’s disease; citation_author=JJ Sutachan, Z Casas, SL Albarracin, BR Stab, I Samudio, J Gonzalez, L Morales, GE Barreto; citation_volume=15; citation_issue=3; citation_publication_date=2012; citation_pages=120-126; citation_doi=10.1179/1476830511Y.0000000033; citation_id=CR3
citation_journal_title=Mov Disord; citation_title=A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson’s disease; citation_author=BJ Snow, FL Rolfe, MM Lockhart, CM Frampton, JD O’Sullivan, V Fung, RAJ Smith, MP Murphy; citation_volume=25; citation_issue=11; citation_publication_date=2010; citation_pages=1670-1674; citation_doi=10.1002/mds.23148; citation_id=CR4
citation_journal_title=Curr Pharm Des; citation_title=Oxidative stress and Parkinson’s disease: new hopes in treatment with herbal antioxidants; citation_author=A Sarrafchi, M Bahmani, H Shirzad, M Rafieian-Kopaei; citation_volume=22; citation_issue=2; citation_publication_date=2016; citation_pages=238-246; citation_doi=10.2174/1381612822666151112151653; citation_id=CR5
Wu F, Xu K, Liu L, Zhang K, Xia L, Zhang M, Teng C, Tong H et al (2019) Vitamin B12 enhances nerve repair and improves functional recovery after traumatic brain injury by inhibiting ER stress-induced neuron injury. Front Pharmacol 10.
https://doi.org/10.3389/fphar.2019.00406
citation_journal_title=Eur J Pharmacol; citation_title=Protective effects of a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in cultured cortical neurons; citation_author=A Akinori, T Yutaka, S Yuko, Y Takeharu; citation_volume=241; citation_issue=1; citation_publication_date=1993; citation_pages=1-6; citation_doi=10.1016/0014-2999(93)90925-8; citation_id=CR7
citation_journal_title=Int J Biol Macromol; citation_title=Vitamin B12 offers neuronal cell protection by inhibiting Aβ-42 amyloid fibrillation; citation_author=P Alam, MK Siddiqi, SK Chaturvedi, M Zaman, RH Khan; citation_volume=99; citation_publication_date=2017; citation_pages=477-482; citation_doi=10.1016/j.ijbiomac.2017.03.001; citation_id=CR8
Shen L (2015) Associations between B vitamins and Parkinson’s disease. Nutrients 7(9).
https://doi.org/10.3390/nu7095333
citation_journal_title=Mov Disord; citation_title=Vitamin B12 and homocysteine levels predict different outcomes in early Parkinson’s disease; citation_author=CW Christine, P Auinger, A Joslin, Y Yelpaala, R Green; citation_volume=33; citation_issue=5; citation_publication_date=2018; citation_pages=762-770; citation_doi=10.1002/mds.27301; citation_id=CR10
citation_journal_title=Arch Neurol; citation_title=Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease; citation_author=ML Evatt, MR DeLong, N Khazai, A Rosen, S Triche, V Tangpricha; citation_volume=65; citation_issue=10; citation_publication_date=2008; citation_pages=1348-1352; citation_doi=10.1001/archneur.65.10.1348; citation_id=CR11
citation_journal_title=Am J Clin Nutr; citation_title=Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease; citation_author=M Suzuki, M Yoshioka, M Hashimoto, M Murakami, M Noya, D Takahashi, M Urashima; citation_volume=97; citation_issue=5; citation_publication_date=2013; citation_pages=1004-1013; citation_doi=10.3945/ajcn.112.051664; citation_id=CR12
citation_journal_title=Arch Neurol; citation_title=Serum vitamin D and the risk of Parkinson disease; citation_author=P Knekt, A Kilkkinen, H Rissanen, J Marniemi, K Sääksjärvi, M Heliövaara; citation_volume=67; citation_issue=7; citation_publication_date=2010; citation_pages=808-811; citation_doi=10.1001/archneurol.2010.120; citation_id=CR13
citation_journal_title=Ann Hum Genet; citation_title=Vitamin D receptor gene as a candidate gene for Parkinson disease; citation_author=MW Butler, A Burt, TL Edwards, S Zuchner, WK Scott, ER Martin, JM Vance, L Wang; citation_volume=75; citation_issue=2; citation_publication_date=2011; citation_pages=201-210; citation_doi=10.1111/j.1469-1809.2010.00631.x; citation_id=CR14
Olivola S, Xodo S, Olivola E, Cecchini F, Londero AP, Driul L (2020) Parkinson’s disease in pregnancy: a case report and review of the literature. Front Neurol 10(1349).
https://doi.org/10.3389/fneur.2019.01349
citation_journal_title=N Engl J Med; citation_title=Clinical characteristics of coronavirus disease 2019 in China; citation_author=W-j Guan, Z-y Ni, Y Hu, W-h Liang, C-q Ou, J-x He, L Liu, H Shan; citation_volume=382; citation_issue=18; citation_publication_date=2020; citation_pages=1708-1720; citation_doi=10.1056/NEJMoa2002032; citation_id=CR16
citation_journal_title=Galen Med J; citation_title=Impact of NiO2 nanoparticles and curcumin on testis torsion/detorsion injury: role of miR-34 and circRNA 0001518; citation_author=SZ Moradi, SA Angaji, M Salehi, M Hashemi; citation_volume=10; citation_publication_date=2021; citation_pages=e2342-e2342; citation_doi=10.31661/gmj.v10i0.2342; citation_id=CR17
citation_journal_title=Brain Res; citation_title=Vitamin D3 attenuates 6-hydroxydopamine-induced neurotoxicity in rats; citation_author=J-Y Wang, J-N Wu, T-L Cherng, BJ Hoffer, H-H Chen, CV Borlongan, Y Wang; citation_volume=904; citation_issue=1; citation_publication_date=2001; citation_pages=67-75; citation_doi=10.1016/S0006-8993(01)02450-7; citation_id=CR18
citation_journal_title=J Isfahan Med School; citation_title=Induction of Parkinson’s disease model in rat by rotenone; citation_author=A Rahimmi, F Khosrobakhsh, E Izadpanah, K Hassanzadeh; citation_volume=32; citation_issue=296; citation_publication_date=2014; citation_pages=1250-1258; citation_id=CR19
Urbach YK, Bode FJ, Nguyen HP, Riess O, von Hörsten S (2010) Neurobehavioral tests in rat models of degenerative brain diseases. In: Anegon I (ed) Rat Genomics: Methods and Protocols. Humana Press, Totowa, pp 333–356.
https://doi.org/10.1007/978-1-60327-389-3_24
citation_journal_title=J Neural Transm; citation_title=The neuroprotective effect of dental pulp cells in models of Alzheimer’s and Parkinson’s disease; citation_author=C Apel, OV Forlenza, VJR Paula, LL Talib, B Denecke, CP Eduardo, WF Gattaz; citation_volume=116; citation_issue=1; citation_publication_date=2008; citation_pages=71; citation_doi=10.1007/s00702-008-0135-3; citation_id=CR21
citation_journal_title=Semin Hematol; citation_title=Flow cytometry in analysis of cell cycle and apoptosis; citation_author=Z Darzynkiewicz, E Bedner, P Smolewski; citation_volume=38; citation_issue=2; citation_publication_date=2001; citation_pages=179-193; citation_doi=10.1016/S0037-1963(01)90051-4; citation_id=CR22
citation_journal_title=J Parkinsons Dis; citation_title=Systematic review of the relationship between vitamin D and Parkinson’s disease; citation_author=LM Rimmelzwaan, NM Schoor, P Lips, HW Berendse, EMW Eekhoff; citation_volume=6; citation_publication_date=2016; citation_pages=29-37; citation_doi=10.3233/JPD-150615; citation_id=CR23
citation_journal_title=J Neurol Sci; citation_title=Peripheral neuropathy in idiopathic Parkinson’s disease: a systematic review; citation_author=P Zis, RA Grünewald, RK Chaudhuri, M Hadjivassiliou; citation_volume=378; citation_publication_date=2017; citation_pages=204-209; citation_doi=10.1016/j.jns.2017.05.023; citation_id=CR24
citation_journal_title=Parkinsonism Relat Disord; citation_title=Small intestinal bacterial overgrowth in Parkinson’s disease; citation_author=AH Tan, S Mahadeva, AM Thalha, PR Gibson, CK Kiew, CM Yeat, SW Ng, SP Ang; citation_volume=20; citation_issue=5; citation_publication_date=2014; citation_pages=535-540; citation_doi=10.1016/j.parkreldis.2014.02.019; citation_id=CR25
citation_journal_title=Mov Disord; citation_title=Relationship of cerebrospinal fluid vitamin B12 status markers with Parkinson’s disease progression; citation_author=CW Christine, P Auinger, N Saleh, M Tian, T Bottiglieri, E Arning, NK Tran, PM Ueland; citation_volume=35; citation_issue=8; citation_publication_date=2020; citation_pages=1466-1471; citation_doi=10.1002/mds.28073; citation_id=CR26
citation_journal_title=Parkinsonism Relat Disord; citation_title=Higher vitamin B12 level at Parkinson’s disease diagnosis is associated with lower risk of future dementia; citation_author=SJ McCarter, C Stang, P Turcano, MM Mielke, F Ali, JH Bower, R Savica; citation_volume=73; citation_publication_date=2020; citation_pages=19-22; citation_doi=10.1016/j.parkreldis.2020.03.009; citation_id=CR27
McCarter SJ, Teigen LM, McCarter AR, Benarroch EE, Louis EKS, Savica R (2019) Low vitamin B12 and Parkinson disease: potential link to reduced cholinergic transmission and severity of disease. In: Mayo Clinic Proceedings, vol 5. Elsevier, pp 757–762
citation_journal_title=Mov Disord; citation_title=Vitamin D from different sources is inversely associated with Parkinson disease; citation_author=L Wang, ML Evatt, LG Maldonado, WR Perry, JC Ritchie, GW Beecham, ER Martin, JL Haines; citation_volume=30; citation_issue=4; citation_publication_date=2015; citation_pages=560-566; citation_doi=10.1002/mds.26117; citation_id=CR29
citation_journal_title=Biophys J ; citation_title=Bistability in apoptosis: roles of Bax, Bcl-2, and mitochondrial permeability transition pores; citation_author=EZ Bagci, Y Vodovotz, TR Billiar, GB Ermentrout, I Bahar; citation_volume=90; citation_issue=5; citation_publication_date=2006; citation_pages=1546-1559; citation_doi=10.1529/biophysj.105.068122; citation_id=CR30
citation_journal_title=Int J Mol Sci; citation_title=miR-211 Plays a critical role in Cnidium officinale Makino extract-induced, ROS/ER stress-mediated apoptosis in U937 and U266 cells; citation_author=JA Cha, H-S Song, B Kang, MN Park, KS Park, S-H Kim, B-S Shim, B Kim; citation_volume=19; citation_issue=3; citation_publication_date=2018; citation_pages=865; citation_doi=10.3390/ijms19030865; citation_id=CR31
citation_journal_title=Nature; citation_title=Natural RNA circles function as efficient microRNA sponges; citation_author=TB Hansen, TI Jensen, BH Clausen, JB Bramsen, B Finsen, CK Damgaard, J Kjems; citation_volume=495; citation_issue=7441; citation_publication_date=2013; citation_pages=384-388; citation_doi=10.1038/nature11993; citation_id=CR32
citation_journal_title=EBioMedicine; citation_title=Circular RNAs: promising biomarkers for human diseases; citation_author=Z Zhang, T Yang, J Xiao; citation_volume=34; citation_publication_date=2018; citation_pages=267-274; citation_doi=10.1016/j.ebiom.2018.07.036; citation_id=CR33