Molecular Medicine
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Association Between HLA DQBl * 03 and Cervical Intra-epithelial Neoplasia
Molecular Medicine - Tập 1 - Trang 161-171 - 1995
Cervical intraepithelial neoplasia (CIN) and cervical cancer have been shown to
be strongly associated with infection by human papillomavirus (HPV). However,
other factors may be contributory in the progression from normal epithelium to
CIN and cervical cancer, since not all women with HPV infection develop disease.
Recently, it was demonstrated that there is a high risk for cervical cancer and
CI...
Epidemic Inflammation: Pondering Obesity
Molecular Medicine - Tập 14 - Trang 485-492 - 2008
Over the past two decades, inflammation has been recognized as a major driver in
the pathogenesis of several common diseases, including atherosclerosis,
diabetes, cancer, and asthma. Over the same period, there has been a steep rise
in the incidence of obesity, a major risk factor for these disorders.
Inflammation of adipose tissue is now recognized to accompany obesity and
contribute to its seque...
Human Skeletal Muscle Stem Cell Antiinflammatory Activity Ameliorates Clinical Outcome in Amyotrophic Lateral Sclerosis Models
Molecular Medicine - Tập 18 - Trang 401-411 - 2011
Mesenchymal stem cell (MSC) therapy is considered one of the most promising
approaches for treating different neurodegenerative disorders, including
amyotrophic lateral sclerosis (ALS). We previously characterized a subpopulation
of human skeletal muscle-derived stem cells (SkmSCs) with MSC-like
characteristics that differentiate into the neurogenic lineage in vitro. In the
present study, we evalu...
Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile sepsis Model
Molecular Medicine - Tập 22 - Trang 455-463 - 2016
Genetic ablation or pharmacologic inhibition of matrix metalloproteinase-8
(MMP8) improves survival in an adult murine sepsis model. Because developmental
age influences the host inflammatory response, we hypothesized that
developmental age influences the role of MMP8 in sepsis. First, we compared
sepsis survival between wild-type (WT, C57BL/6) and MMP8 null juvenile-aged mice
(12–14 d) after intr...
Suppression of Coronary Atherosclerosis by Helix B Surface Peptide, a Nonerythropoietic, Tissue-Protective Compound Derived from Erythropoietin
Molecular Medicine - Tập 19 - Trang 195-202 - 2013
Erythropoietin (EPO), a type I cytokine originally identified for its critical
role in hematopoiesis, has been shown to have non-hematopoietic,
tissue-protective effects, including suppression of atherosclerosis. However,
prothrombotic effects of EPO hinder its potential clinical use in nonanemic
patients. In the present study, we investigated the antiatherosclerotic effects
of helix B surface pep...
Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway
Molecular Medicine - Tập 28 - Trang 1-19 - 2022
The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits
remain unclear. Here, our study found that about 3 months CIH treatment induced
lipid droplets (LDs) accumulation in hippocampal nerve and glia cells of C57BL/6
mice, and caused severe neuro damage including neuron lesions, neuroblast (NB)
apoptosis and abnormal glial activation. Studies have shown that the neuronal
me...
Generation of Monoclonal Antibodies against Human Prion Proteins in PrP0/0 Mice
Molecular Medicine - Tập 2 - Trang 725-734 - 1996
Prion diseases belong to a group of neurodegenerative disorders affecting humans
and animals. The human diseases indude kuru, Creutzfeldt-Jakob disease (CJD),
Gerstmann-Sträussler-Scheinker syndrome (GSS), and fatal familial insomnia
(FFI). The pathogenic mechanisms of the prion diseases are not yet understood.
Monoclonal antibodies provide valuable tools in the diagnosis, as well as in the
basic ...
LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter
Molecular Medicine - Tập 28 - Trang 1-12 - 2022
Long non-coding RNAs (lncRNAs) have emerged as regulators of human malignancies,
including ovarian cancer (OC). LncRNA KCNQ1OT1 could promote OC progression, and
EIF2B5 was associated with development of several tumors. This project was aimed
to explore the role of lncRNA KCNQ1OT1 in OC development, as well as the
involving action mechanism. Reverse transcription quantitative polymerase chain
reac...
Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2
Molecular Medicine - Tập 26 - Trang 1-8 - 2020
Propofol is an intravenous anesthetic agent that commonly induces significant
neuroapoptosis. MicroRNAs (miRNAs) have been reported to participate in the
regulation of propofol exposure-mediated neurotoxicity. MiR-215, as one of
miRNAs, was found to regulate nerve cell survival. However, the mechanism
through which miRNAs regulate propofol exposure-mediated neurotoxicity is still
unclear. Real-tim...
High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
Molecular Medicine - Tập 21 - Trang S6-S12 - 2015
High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear
protein that exerts divergent biological tasks inside and outside of cells. The
functions of HMGB1 depend on location, binding partners and redox states of the
molecule. In the nucleus, HMGB1 organizes DNA and nucleosomes and regulates gene
transcription. Upon cell activation or injury, nuclear HMGB1 can translocate to
th...
Tổng số: 1,645
- 1
- 2
- 3
- 4
- 5
- 6
- 10