Molecular Medicine

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* Dữ liệu chỉ mang tính chất tham khảo

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A Journey in Science: The Birth of Organ Transplantation with Particular Reference to Alloengraftment Mechanisms
Molecular Medicine - - 2015
Thomas E. Starzl
Peripheral Administration of Human Adrenomedullin and Its Binding Protein Attenuates Stroke-Induced Apoptosis and Brain Injury in Rats
Molecular Medicine - Tập 17 - Trang 1075-1083 - 2011
Wayne W. Chaung, Rongqian Wu, Youxin Ji, Zhimin Wang, Weifeng Dong, Cletus Cheyuo, Lei Qi, Xiaoling Qiang, Haichao Wang, Ping Wang
Stroke is a leading cause of death and the primary medical cause of acquired adult disability worldwide. The progressive brain injury after acute stroke is partly mediated by ischemia-elicited inflammatory responses. The vasoactive hormone adrenomedullin (AM), upregulated under various inflammatory conditions, counterbalances inflammatory responses. However, regulation of AM activity in ischemic s...... hiện toàn bộ
Differential network analysis and protein-protein interaction study reveals active protein modules in glucocorticoid resistance for infant acute lymphoblastic leukemia
Molecular Medicine - Tập 25 - Trang 1-12 - 2019
Zaynab Mousavian, Abbas Nowzari-Dalini, Yasir Rahmatallah, Ali Masoudi-Nejad
Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children and Glucocorticoids (GCs) form an essential component of the standard chemotherapy in most treatment regimens. The category of infant ALL patients carrying a translocation involving the mixed lineage leukemia (MLL) gene (gene KMT2A) is characterized by resistance to GCs and poor clinical outcome. Although so...... hiện toàn bộ
Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial
Molecular Medicine - Tập 8 - Trang 495-505 - 2002
Hannelore Ehrenreich, Martin Hasselblatt, Christoph Dembowski, Lukas Cepek, Piotr Lewczuk, Michael Stiefel, Hans-Heino Rustenbeck, Norbert Breiter, Sonja Jacob, Friederike Knerlich, Matthias Bohn, Wolfgang Poser, Eckart Rüther, Michael Kochen, Olaf Gefeller, Christoph Gleiter, Thomas C. Wessel, Marc De Ryck, Loretta Itri, Hilmar Prange, Anthony Cerami, Michael Brines, Anna-Leena Sirén
Erythropoietin (EPO) and its receptor play a major role in embryonic brain, are weakly expressed in normal postnatal/adult brain and up-regulated upon metabolic stress. EPO protects neurons from hypoxic/ischemic injury. The objective of this trial is to study the safety and efficacy of recombinant human EPO (rhEPO) for treatment of ischemic stroke in man. The trial consisted of a safety part and a...... hiện toàn bộ
Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats
Molecular Medicine - Tập 27 - Trang 1-13 - 2021
Zhongliu Cao, Yanfeng Wu, Lingling Yu, Lingfeng Zou, Liu Yang, Sijian Lin, Jue Wang, Zhen Yuan, Jianghua Dai
Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) embedded in a bio-compatible matrix has been demonstrated as a promising strategy for the treatment of bone defects. This study was designed to explore the effect and mechanism of exosomes derived from mature dendritic cells (mDC-Exo) on the BM-MSCs-mediated bone regeneration using the matrix support in an athymic rat model of...... hiện toàn bộ
Proteomic Analysis Permits the Identification of New Biomarkers of Arterial Wall Remodeling in Hypertension
Molecular Medicine - Tập 14 - Trang 383-394 - 2008
Sandrine Delbosc, Mounsif Haloui, Liliane Louedec, Morgan Dupuis, Myriam Cubizolles, Vladimir N. Podust, Eric T. Fung, Jean-Baptiste Michel, Olivier Meilhac
Hypertension represents one of the main risk factors for vascular diseases. Genetic susceptibility may influence the rate of its development and the associated vascular remodeling. To explore markers of hypertension-related morbidity, we have used surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry to study changes in proteins released by the aorta of two rat ...... hiện toàn bộ
Phương Pháp Liệu Pháp Hiệu Quả Cho Ung Thư Gan Thí Nghiệm Bằng Cách Kết Hợp Vận Chuyển Mạch Máu Các Virus Oncolytic Herpes Simplex Và Chuyển Giao Gene Cytokine Qua Amplicon Dịch bởi AI
Molecular Medicine - Tập 7 - Trang 561-568 - 2001
Jonathan S. Zager, Keith A. Delman, Sandeep Malhotra, Michael I. Ebright, Joseph J. Bennett, Tara Kates, Mark Halterman, Howard Federoff, Yuman Fong
Các vector dựa trên virus herpes simplex type I (HSV) đã được sử dụng thử nghiệm cho liệu pháp gene tự sát, chuyển giao gene điều hòa miễn dịch và liệu pháp oncolytic trực tiếp. Nghiên cứu hiện tại áp dụng khái niệm mới về việc vận chuyển virus oncolytic theo vùng kết hợp hoặc phục vụ như virus hỗ trợ để đóng gói các vector amplicon dựa trên herpes mang một transgene cytokine, với mục tiêu xác địn...... hiện toàn bộ
#virus herpes simplex #liệu pháp gene #ung thư gan #cytokine #hệ miễn dịch
OTC intron 4 variations mediate pathogenic splicing patterns caused by the c.386G>A mutation in humans and spfash mice, and govern susceptibility to RNA-based therapies
Molecular Medicine - Tập 27 Số 1 - 2021
Claudia Sacchetto, Laura Peretto, Francisco E. Baralle, Iva Maestri, Francesca Tassi, Francesco Bernardi, Stan F.J. van de Graaf, Franco Pagani, Mirko Pinotti, Dario Balestra
Abstract Background Aberrant splicing is a common outcome in the presence of exonic or intronic variants that might hamper the intricate network of interactions defining an exon in a specific gene context. Therefore, the evaluation of the functional, and potentially pathological, role of nucleotide ...... hiện toàn bộ
Phosphorothioate Oligonucleotides Reduce PrPSc Levels and Prion Infectivity in Cultured Cells
Molecular Medicine - Tập 13 - Trang 190-198 - 2007
Marcela V. Karpuj, Kurt Giles, Sagit Gelibter-Niv, Michael R. Scott, Vishwanath R. Lingappa, Francis C. Szoka, David Peretz, Wilfred Denetclaw, Stanley B. Prusiner
Prions are composed solely of the disease-causing prion protein (PrPSc) that is formed from the cellular isoform PrPC by a post-translational process. Here we report that short phosphorothioate DNA (PS-DNA) oligonucleotides diminished the levels of both PrPC and PrPSc in prion-infected neuroblastoma (ScN2a) cells. The effect of PS-DNA on PrP levels was independent of the nucleotide sequence. The e...... hiện toàn bộ
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