Molecular Diversity
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Review on advancements of pyranopyrazole: synthetic routes and their medicinal applications
Molecular Diversity - - Trang 1-48 - 2024
Pyranopyrazoles are among the most distinguished, biologically potent, and
exciting scaffolds in medicinal chemistry and drug discovery. Synthesis and
design of pyranopyrazoles using functional modifications via multicomponent
reactions (MCRs) are thoroughly found in synthetic protocols by forming new C–C,
C–N, and C–O bonds. This review aims to focus on the biological importance of
pyranopyrazole...
Efficient one-pot synthesis of new 1-amino substituted pyrrolo[1,2-a]quinoline-4-carboxylate esters via copper-free Sonogashira coupling reactions
Molecular Diversity - Tập 21 - Trang 29-36 - 2016
The reactions of several 2-chloroquinoline-3-carboxylate esters with propargyl
alcohol and a secondary amine in the presence of palladium catalyst leads to the
formation of new alkyl 1-amino substituted pyrrolo[1,2-a]quinoline-4-carboxylate
derivatives. This one-pot process, carried out in the absence of any copper
salt, provides an efficient method for the synthesis of functionalized
pyrrolo[1,2-...
Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulations
Molecular Diversity - - 2022
Advancements in tetronic acid chemistry. Part 2: Use as a simple precursor to privileged heterocyclic motifs
Molecular Diversity - - 2016
Synthesis, spectral analysis, DFT calculations, biological potential and molecular docking studies of indole appended pyrazolo-triazine
Molecular Diversity - Tập 27 - Trang 679-693 - 2022
A series of novel
5-(3,5-disubstituted-1H-indol-2-yl)-2,3-dimethyl-1-phenyl-2,6-dihydro-1H-pyrazolo[4,3-e][1,2,4]triazines
(3a-l) were synthesized in single step from 3,5-disubstituted
indole-2-carbohydrazide and 4-aminoantipyrine under acidic conditions with
excellent yields. The various spectroscopic methods were used to prove the
formation of all these products. The compounds 3a, 3b, 3e, 3f, 3i...
Reaction between alkyl isocyanides and isopropylidene Meldrum’s acid in the presence of bidentate nucleophiles
Molecular Diversity - - 2006
The reaction between alkyl isocyanides and isopropylidene Meldrum’s acid in the
presence of 1,2-ethanediol leads to N
1-(alkyl)-2-(5,7-dioxo-1,4-dioxepane-6-yl)-2-methylpropanamides. 1,3-Propanediol
or 1,4-butanediol produce hydroxyalkyl
1-(tert-butyl)-4,4-dimethyl-2,5-dioxo-3-pyrrolidinecarboxylates. When the
reaction was performed in the presence of catechol, bis(2-hydroxyphenyl)
2-[2-(tert-buty...
Recent advances in the area of plant-based anti-cancer drug discovery using computational approaches
Molecular Diversity - - Trang 1-25 - 2023
Phytocompounds are a well-established source of drug discovery due to their
unique chemical and functional diversities. In the area of cancer therapeutics,
several phytocompounds have been used till date to design and develop new drugs.
One of the desired interests of pharmaceutical companies and researchers
globally is that new anti-cancer leads are discovered, for which phytocompounds
can be con...
Eco-friendly and regiospecific intramolecular cyclization reactions of cyano and carbonyl groups in N,N-disubstituted cyanamide
Molecular Diversity - Tập 26 - Trang 2813-2823 - 2022
Eco-friendly, low-cost and high-yielding synthetic route toward imidazoles and
oxazoles has been developed.
1-(4,6-Dimethylpyrimidin-2-yl)-2-(alkylamino)-1,5-dihydro-4H-imidazol-4-one 3a–c
have been synthesized via regiospecific reaction of ethyl
2-(N-(4,6-dimethylpyrimidin-2-yl)cyanamide)acetate 1 with primary aliphatic
amines in water as green solvent. While, the reaction between
4,6-dimethylpyr...
Ionic liquid-supported synthesis of dihydroquinazolines and tetrahydroquinazolines under microwave irradiation
Molecular Diversity - Tập 16 - Trang 241-249 - 2011
An efficient microwave-assisted and water-soluble ionic liquid (IL)-supported
synthesis of medicinally important dihydro- and tetrahydroquinazolines has been
developed. The protocol involves the SN2 substitution reaction of IL-bound
4-bromomethyl-3-nitrobenzoic acid with various primary amines to provide
IL-bound 4-((alkylamino) methyl)-3-nitrobenzoate under microwave irradiation.
Further elaborat...
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