Molecular Brain

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Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice
Molecular Brain - Tập 3 - Trang 1-13 - 2010
Hiroki Toyoda, Ming-Gao Zhao, Valentina Mercaldo, Tao Chen, Giannina Descalzi, Satoshi Kida, Min Zhuo
Calcium/calmodulin-dependent kinase IV (CaMKIV) phosphorylates the major transcription factor, cyclic AMP-responsive element binding protein (CREB), which plays key roles in synaptic plasticity and memory consolidation. Our previous study showed that long-term potentiation (LTP) in the anterior cingulate cortex (ACC) was significantly enhanced in transgenic mice overexpressing CaMKIV. Considering ...... hiện toàn bộ
Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats
Molecular Brain - Tập 5 - Trang 1-12 - 2012
Jia-Le Yang, Bo Xu, Shuang-Shuang Li, Wei-Shi Zhang, Hua Xu, Xiao-Ming Deng, Yu-Qiu Zhang
Spinal glia, particularly microglia and astrocytes, are of the utmost importance in the development and maintenance of chronic pain. A recent study from our laboratory revealed that gabapentin, a recommended first-line treatment for multiple neuropathic conditions, could also efficiently antagonize thermal hyperalgesia evoked by complete Freund's adjuvant (CFA)-induced monoarthritis (MA). In the p...... hiện toàn bộ
"Color Timer" mice: visualization of neuronal differentiation with fluorescent proteins
Molecular Brain - Tập 3 - Trang 1-9 - 2010
Hiroaki Kanki, Marilia Kimie Shimabukuro, Atsushi Miyawaki, Hideyuki Okano
The molecular mechanisms governing the differentiation of neural stem cells (NSCs) into neuronal progenitor cells and finally into neurons are gradually being revealed. The lack of convenient means for real-time determination of the stages of differentiation of individual neural cells, however, has been hindering progress in elucidating the mechanisms. In order to be able to easily identify the st...... hiện toàn bộ
Voluntary wheel running promotes myelination in the motor cortex through Wnt signaling in mice
Molecular Brain - Tập 12 - Trang 1-10 - 2019
Jian Zheng, Xuan Sun, Chaolin Ma, Bao-ming Li, Fei Luo
Myelin of the central nervous system exhibits strong plasticity, and skill learning exercise promotes oligodendrogenesis and adaptive myelination. Increasing evidence shows that brain structures and functions are affected by physical activity. However, the impact of voluntary physical activity on central myelination and its underlying mechanism remains unclear. The present study aimed to investiga...... hiện toàn bộ
The transcription factor RBP-J is essential for retinal cell differentiation and lamination
Molecular Brain - Tập 2 - Trang 1-17 - 2009
Min-Hua Zheng, Ming Shi, Zhe Pei, Fang Gao, Hua Han, Yu-Qiang Ding
The highly ordered vertebrate retina is composed of seven cell types derived from a common pool of retinal progenitor cells (RPCs), and is a good model for the studies of cell differentiation and interaction during neural development. Notch signaling plays a pivotal role in retinogenesis in mammals, but the full scope of the functions of Notch pathway, and the underlying molecular mechanisms, rema...... hiện toàn bộ
A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
Molecular Brain - Tập 7 - Trang 1-14 - 2014
Mie Kubota-Sakashita, Kazuya Iwamoto, Miki Bundo, Tadafumi Kato
Pre-mRNAs of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propanoic acid (AMPA)/kainate glutamate receptors undergo post-transcriptional modification known as RNA editing that is mediated by adenosine deaminase acting on RNA type 2 (ADAR2). This modification alters the amino acid sequence and function of the receptor. Glutamatergic signaling has been suggested to have a role in mood disorders and ...... hiện toàn bộ
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
Molecular Brain - Tập 2 - Trang 1-17 - 2009
Valerie Cullen, Maria Lindfors, Juliana Ng, Anders Paetau, Erika Swinton, Piotr Kolodziej, Heather Boston, Paul Saftig, John Woulfe, Mel B Feany, Liisa Myllykangas, Michael G Schlossmacher, Jaana Tyynelä
Elevated SNCA gene expression and intracellular accumulation of the encoded α-synuclein (aSyn) protein are associated with the development of Parkinson disease (PD). To date, few enzymes have been examined for their ability to degrade aSyn. Here, we explore the effects of CTSD gene expression, which encodes the lysosomal protease cathepsin D (CathD), on aSyn processing. Over-expression of human CT...... hiện toàn bộ
NADPH oxidase mediates β-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures
Molecular Brain - Tập 2 - Trang 1-10 - 2009
Faridis Serrano, Angela Chang, Caterina Hernandez, Robia G Pautler, J David Sweatt, Eric Klann
Previous studies have shown that beta amyloid (Aβ) peptide triggers the activation of several signal transduction cascades in the hippocampus, including the extracellular signal-regulated kinase (ERK) cascade. In this study we sought to characterize the cellular localization of phosphorylated, active ERK in organotypic hippocampal cultures after acute exposure to either Aβ (1-42) or nicotine. We o...... hiện toàn bộ
Enhancement of dendritic persistent Na+ currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision
Molecular Brain - Tập 11 - Trang 1-10 - 2018
Weonjin Yu, Jong-Woo Sohn, Jaehan Kwon, Suk-Ho Lee, Sooyun Kim, Won-Kyung Ho
Timing and temporal precision of action potential generation are thought to be important for encoding of information in the brain. The ability of single neurons to transform their input into output action potential is primarily determined by intrinsic excitability. Particularly, plastic changes in intrinsic excitability represent the cellular substrate for spatial memory formation in CA1 pyramidal...... hiện toàn bộ
Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the common marmoset
Molecular Brain - Tập 12 - Trang 1-10 - 2019
Koji Ohira, Hideo Hagihara, Miki Miwa, Katsuki Nakamura, Tsuyoshi Miyakawa
The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely used to treat depression and anxiety disorders. Chronic FLX treatment reportedly induces cellular responses in the brain, including increased adult hippocampal and cortical neurogenesis and reversal of neuron maturation in the hippocampus, amygdala, and cortex. However, because most previous studies have used rodent models, it r...... hiện toàn bộ
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