Molecular Brain

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Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation
Molecular Brain - Tập 6 - Trang 1-8 - 2013
Liangwu Sun, Yingjun Zhao, Kun Zhou, Hudson H Freeze, Yun-wu Zhang, Huaxi Xu
Congenital disorders of glycosylation (CDGs) are inherited diseases caused by glycosylation defects. Incorrectly glycosylated proteins induce protein misfolding and endoplasmic reticulum (ER) stress. The most common form of CDG, PMM2-CDG, is caused by deficiency in the cytosolic enzyme phosphomannomutase 2 (PMM2). Patients with PMM2-CDG exhibit a significantly reduced number of cerebellar Purkinje...... hiện toàn bộ
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB
Molecular Brain - Tập 5 - Trang 1-12 - 2012
Eric R Kandel
The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory and its conversion to long-term memory for both implicit (procedural) and explicit (declarative) memory. I here first trace the backgrou...... hiện toàn bộ
Correction to: Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse
Molecular Brain - Tập 15 Số 1 - 2022
Siqi Wang, Yuan Sun, Shaozheng Hu, Cen Lou, Yuan‐Bo Pan
MATH5 controls the acquisition of multiple retinal cell fates
Molecular Brain - - 2010
Liang Feng, Zheng-hua Xie, Qian Ding, Xiaoling Xie, Richard T Libby, Lin Gan
Math5-null mutation results in the loss of retinal ganglion cells (RGCs) and in a concurrent increase of amacrine and cone cells. However, it remains unclear whether there is a cell fate switch of Math5-lineage cells in the absence of Math5 and whether MATH5 cell-autonomously regulates the differentiation of the above retinal neurons. Here, we performed a lineage analysis of Math5-expressing cells...... hiện toàn bộ
Vorinostat dương tính điều chỉnh biểu hiện gen tính linh hoạt synapse và mật độ gai trong tế bào thần kinh nhiễm HIV: vai trò của nicotine trong sự tiến triển của rối loạn nhận thức thần kinh liên quan đến HIV Dịch bởi AI
Molecular Brain - Tập 7 - Trang 1-17 - 2014
Venkata Subba Rao Atluri, Sudheesh Pilakka-Kanthikeel, Thangavel Samikkannu, Vidya Sagar, Kesava Rao Venkata Kurapati, Shailendra K Saxena, Adriana Yndart, Andrea Raymond, Hong Ding, Oscar Hernandez, Madhavan PN Nair
Rối loạn nhận thức thần kinh liên quan đến HIV (HAND) được đặc trưng bởi sự phát triển của những bất thường về nhận thức, hành vi và vận động, xảy ra ở khoảng 50% cá nhân nhiễm HIV. Tại Hoa Kỳ, tỷ lệ hút thuốc lá dao động từ 35-70% ở các cá nhân nhiễm HIV so với 20% trong tổng dân số. Suy giảm nhận thức ở những người nghiện thuốc lá nặng đã được báo cáo rõ ràng. Tuy nhiên, các tác động cộng hưởng ...... hiện toàn bộ
#HIV #rối loạn nhận thức thần kinh #HAND #nicotine #vorinostat #tế bào thần kinh #tính linh hoạt synapse
Propagation of Tau aggregates
Molecular Brain - Tập 10 - Trang 1-9 - 2017
Michel Goedert, Maria Grazia Spillantini
Since 2009, evidence has accumulated to suggest that Tau aggregates form first in a small number of brain cells, from where they propagate to other regions, resulting in neurodegeneration and disease. Propagation of Tau aggregates is often called prion-like, which refers to the capacity of an assembled protein to induce the same abnormal conformation in a protein of the same kind, initiating a sel...... hiện toàn bộ
Networked neural spheroid by neuro-bundle mimicking nervous system created by topology effect
Molecular Brain - Tập 8 - Trang 1-12 - 2015
Gi Seok Jeong, Joon Young Chang, Ji Soo Park, Seung-A Lee, DoYeun Park, Junsung Woo, Heeyoung An, C Justin Lee, Sang-Hoon Lee
In most animals, the nervous system consists of the central nervous system (CNS) and the peripheral nervous system (PNS), the latter of which connects the CNS to all parts of the body. Damage and/or malfunction of the nervous system causes serious pathologies, including neurodegenerative disorders, spinal cord injury, and Alzheimer’s disease. Thus, not surprising, considerable research effort, bot...... hiện toàn bộ
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies
Molecular Brain - Tập 8 - Trang 1-17 - 2015
Daisuke Nishizawa, Shinya Kasai, Junko Hasegawa, Naomi Sato, Hidetaka Yamada, Fumihiko Tanioka, Makoto Nagashima, Ryoji Katoh, Yasuo Satoh, Megumi Tagami, Hiroshi Ujike, Norio Ozaki, Toshiya Inada, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Mitsuhiko Yamada, Naoki Kondo, Moo-Jun Won, Nobuya Naruse, Kumi Uehara-Aoyama, Masanari Itokawa, Kazutaka Ohi, Ryota Hashimoto, Kumpei Tanisawa, Tomio Arai, Seijiro Mori, Motoji Sawabe, Makiko Naka-Mieno, Yoshiji Yamada, Miki Yamada, Noriko Sato, Masaaki Muramatsu, Masashi Tanaka, Yoko Irukayama-Tomobe, Yuki C. Saito, Takeshi Sakurai, Masakazu Hayashida, Haruhiko Sugimura, Kazutaka Ikeda
Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association studies (GWASs) to be associated with smoking behavior and the vulnerability to nicotine dependence, such studies have been mostly conducted with subjects with European ancestry. However, genet...... hiện toàn bộ
Acute inhibition of OGA sex-dependently alters the networks associated with bioenergetics, autophagy, and neurodegeneration
Molecular Brain - - 2022
Van N. Huynh, Gloria A. Benavides, Michelle S. Johnson, Xiaosen Ouyang, Balu K. Chacko, Edie Osuma, Toni Mueller, John Chatham, Victor M. Darley-Usmar, Jianhua Zhang
The accumulation of neurotoxic proteins characteristic of age-related neurodegenerative pathologies such as Alzheimer’s and Parkinson’s diseases is associated with the perturbation of metabolism, bioenergetics, and mitochondrial quality control. One approach to exploit these interactions therapeutically is to target the pathways that regulate metabolism. In this respect, the nutrient-sensing hexos...... hiện toàn bộ
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export
Molecular Brain - Tập 15 - Trang 1-10 - 2022
Noriyuki Nakashima, Akiko Nakashima, Kie Nakashima, Makoto Takano
Olfactory marker protein (OMP) is a cytosolic protein expressed in mature olfactory receptor neurons (ORNs). OMP modulates cAMP signalling and regulates olfactory sensation and axonal targeting. OMP is a small soluble protein, and passive diffusion between nucleus and cytoplasm is expected. However, OMP is mostly situated in the cytosol and is only sparsely detected in the nuclei of a subset of OR...... hiện toàn bộ
Tổng số: 917   
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