Molecular Brain
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Calcium/calmodulin-dependent kinase IV contributes to translation-dependent early synaptic potentiation in the anterior cingulate cortex of adult mice
Molecular Brain - Tập 3 - Trang 1-13 - 2010
Calcium/calmodulin-dependent kinase IV (CaMKIV) phosphorylates the major transcription factor, cyclic AMP-responsive element binding protein (CREB), which plays key roles in synaptic plasticity and memory consolidation. Our previous study showed that long-term potentiation (LTP) in the anterior cingulate cortex (ACC) was significantly enhanced in transgenic mice overexpressing CaMKIV. Considering ......
Cav3.2 T-type calcium channels control acute itch in mice
Molecular Brain - Tập 13 - Trang 1-7 - 2020
Cav3.2 T-type calcium channels are important mediators of nociceptive signaling, but their roles in the transmission of itch remains poorly understood. Here we report a key involvement of these channels as key modulators of itch/pruritus-related behavior. We compared scratching behavior responses between wild type and Cav3.2 null mice in models of histamine- or chloroquine-induced itch. We also ev......
Ca2+/Calmodulin-dependent protein Kinase II interacts with group I Metabotropic Glutamate and facilitates Receptor Endocytosis and ERK1/2 signaling: role of β-Amyloid
Molecular Brain - Tập 8 - Trang 1-15 - 2015
Agonist stimulation of Group I metabotropic glutamate receptors (mGluRs) initiates their coupling to the heterotrimeric G protein, Gαq/11, resulting in the activation of phospholipase C, the release of Ca2+ from intracellular stores and the subsequent activation of protein kinase C. However, it is now recognized that mGluR5a also functions as a receptor for cellular prion protein (PrPC) and β-amyl......
c-Fos expression in the paternal mouse brain induced by communicative interaction with maternal mates
Molecular Brain - Tập 7 - Trang 1-11 - 2014
Appropriate parental care by fathers greatly facilitates health in human family life. Much less is known from animal studies regarding the factors and neural circuitry that affect paternal behavior compared with those affecting maternal behavior. We recently reported that ICR mouse sires displayed maternal-like retrieval behavior when they were separated from pups and caged with their mates (co-ho......
Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome
Molecular Brain - Tập 8 - Trang 1-11 - 2015
Williams-Beuren Syndrome (WBS) is caused by the microdeletion of approximately 25 genes on chromosome 7q11.23, and is characterized by a spectrum of cognitive and behavioural features. We generated cortical neurons from a WBS individual and unaffected (WT) control by directed differentiation of induced pluripotent stem cells (iPSCs). Single cell mRNA analyses and immunostaining demonstrated very e......
Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner
Molecular Brain - Tập 15 - Trang 1-4 - 2022
As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca levels in an NMDAR-dependent manner. Chelating Cu in the perfusate induced a substantial increase in Ca level......
EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-κB signaling pathway
Molecular Brain - - 2018
Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies
Molecular Brain - Tập 8 - Trang 1-17 - 2015
Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association studies (GWASs) to be associated with smoking behavior and the vulnerability to nicotine dependence, such studies have been mostly conducted with subjects with European ancestry. However, genet......
Modulating and monitoring the functionality of corticostriatal circuits using an electrostimulable microfluidic device
Molecular Brain - Tập 16 - Trang 1-10 - 2023
The central nervous system is organized into different neural circuits, each with particular functions and properties. Studying neural circuits is essential to understanding brain function and neuronal diseases. Microfluidic systems are widely used for reconstructing and studying neural circuits but still need improvement to allow modulation and monitoring of the physiological properties of circui......
Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain
Molecular Brain - Tập 11 - Trang 1-3 - 2018
A class of NAD-dependent protein deacetylases, the Sirtuin (SIRT) family of proteins is involved in aging, cell survival, and neurodegeneration. Recently, SIRT proteins, including SIRT6, have been reported to be important in learning and memory. However, the role of SIRT6 in excitatory brain neurons in cognitive behaviors is not well characterized. We investigated how cognitive behaviors are affec......
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