Molecular Autism
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Autism traits outweigh alexithymia traits in the explanation of mentalising performance in adults with autism but not in adults with rejected autism diagnosis
Molecular Autism - Tập 13 - Trang 1-9 - 2022
Pronounced alexithymia traits have been found in autism spectrum disorder (ASD) and recent research has been carving out the impact alexithymia traits might have on mentalising deficits associated with ASD. In this cross-sectional study, a large representative referral population for diagnostic examination for possible ASD (n = 400) was screened for clinical alexithymia with a German version of th......
Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional studyAbstract
Background
Sensory over-responsivity (SOR) is an impairing sensory processing challenge in autism spectrum disorder (ASD) which shows heterogenous developmental trajectories and appears to improve into adulthood in some but not all autistic individuals. However, the neural mechanisms underl... ...
Molecular Autism -
Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort
Molecular Autism - Tập 15 - Trang 1-10 - 2024
Autism spectrum disorder (henceforth autism) is a complex neurodevelopmental condition associated with differences in gray matter (GM) volume covariations, as reported in our previous study of the Longitudinal European Autism Project (LEAP) data. To make progress on the identification of potential neural markers and to validate the robustness of our previous findings, we aimed to replicate our res......
Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice
Molecular Autism - - 2024
Sleep disturbances are a common comorbidity to most neurodevelopmental disorders and tend to worsen disease symptomatology. It is thus crucial to understand mechanisms underlying sleep disturbances to improve patients’ quality of life. Neuroligin-2 (NLGN2) is a synaptic adhesion protein regulating GABAergic transmission. It has been linked to autism spectrum disorders and schizophrenia in humans, ......
The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder
Molecular Autism - Tập 9 - Trang 1-13 - 2018
Histological evidence suggests that autism spectrum disorder (ASD) is accompanied by a reduced integrity of the grey-white matter boundary. This has also recently been confirmed by a structural neuroimaging study in vivo reporting significantly reduced grey-white matter tissue contrast (GWC) in adult individuals (18–42 years of age) with ASD relative to typically developing (TD) controls. However,......
Autism in DSM-5: progress and challenges
Molecular Autism - Tập 4 - Trang 1-6 - 2013
Since Kanner’s first description of autism there have been a number of changes in approaches to diagnosis with certain key continuities . Since the Fourth edition of the Diagnostic and Statistical Manual (DSM-IV) appeared in 1994 there has been an explosion in research publications. The advent of changes in DSM-5 presents some important moves forward as well as some potential challenges. The vario......
Dysregulation of fragile X mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study
Molecular Autism - Tập 2 - Trang 1-11 - 2011
Fragile X syndrome is caused by loss of function of the fragile X mental retardation 1 (FMR1) gene and shares multiple phenotypes with autism. We have previously found reduced expression of the protein product of FMR1 (FMRP) in vermis of adults with autism. In the current study, we have investigated levels of FMRP in the superior frontal cortex of people with autism and matched controls using West......
Savant syndrome has a distinct psychological profile in autism
Molecular Autism - Tập 9 - Trang 1-18 - 2018
Savant syndrome is a condition where prodigious talent can co-occur with developmental conditions such as autism spectrum conditions (autism). It is not yet clear why some autistic people develop savant skills while others do not. We tested three groups of adults: autistic individuals who have savant skills, autistic individuals without savant skills, and typical controls without autism or savant ......
Task-related functional connectivity in autism spectrum conditions: an EEG study using wavelet transform coherence
Molecular Autism - Tập 4 Số 1 - Trang 1 - 2013
Prenatal exposure to valproic acid increases miR-132 levels in the mouse embryonic brain
Molecular Autism - Tập 8 - Trang 1-9 - 2017
MicroRNAs, small non-coding RNAs, are highly expressed in the mammalian brain, and the dysregulation of microRNA levels may be involved in neurodevelopmental disorders such as autism spectrum disorder (ASD). In the present study, we examined whether prenatal valproic acid (VPA) exposure affects levels of microRNAs, especially the brain specific and enriched microRNAs, in the mouse embryonic brain.......
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