Cobalt chloride speciation, mechanisms of cytotoxicity on human pulmonary cells, and synergistic toxicity with zincMetallomics - Tập 5 Số 2 - Trang 133 - 2013
Carole Bresson, Carine Darolles, Asunción Carmona, Céline Gautier, Nicole Sage, Stéphane Roudeau, Richard Ortega, É. Ansoborlo, Véronique Malard
Huntington’s disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 miceMetallomics - Tập 12 Số 7 - Trang 1118-1130 - 2020
Anna C. Pfalzer, Jordyn M. Wilcox, Simona G. Codreanu, Melissa S. Totten, Terry Jo Bichell, Timothy C. Halbesma, Preethi Umashanker, Kevin Yang, Nancy L. Parmalee, Stacy D. Sherrod, Keith M. Erikson, Fiona E. Harrison, John A. McLean, Michael Aschner, Aaron B. Bowman
Abstract Manganese (Mn) is an essential micronutrient required for the proper
function of several enzymes. Accumulating evidence demonstrates a selective
decrease of bioavailable Mn in vulnerable cell types of Huntington’s Disease
(HD), an inherited progressive neurodegenerative disorder with no cure.
Amelioration of underlying pathophysiology, such as alterations in Mn-dependent
biology, may be t... hiện toàn bộ