Metabolomics
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Comparative analysis of bioactive phytochemicals from Scutellaria baicalensis, Scutellaria lateriflora, Scutellaria racemosa, Scutellaria tomentosa and Scutellaria wrightii by LC-DAD-MS
Metabolomics - Tập 7 - Trang 446-453 - 2010
Scutellaria is a geographically widespread and diverse genus of the Lamiaceae family of herbaceous plants commonly known as skullcaps. Scutellaria is used widely as an ethnobotanical herb for the treatment of various ailments ranging from cancers, cirrhosis, jaundice, hepatitis, anxiety and nervous disorders. We used (1) reverse-phase liquid chromatography coupled to a diode array detector (LC-DAD......
Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo
Metabolomics - Tập 17 - Trang 1-11 - 2021
Vitiligo pathogenesis is complicated, and several possibilities were suggested. However, it is well-known that the metabolism of pigments plays a significant role in the pathogenicity of the disease. We explored the role of amino acids in vitiligo using targeted metabolomics. The amino acid profile was studied in plasma using liquid chromatography. First, 22 amino acids were derivatized and precis......
Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cells
Metabolomics - Tập 11 - Trang 71-80 - 2014
Lactate dehydrogenase A (LDHA) is the enzyme that converts pyruvate to lactate and oxidizes the reduced form of nicotinamide adenine dinucleotide to NAD+. Several human cancers including the pancreas display elevated expression of LDHA. Because of its essential role in cancer metabolism, LDHA has been considered to be a potential target for cancer therapy. Recently, we have shown that a green tea ......
A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites
Metabolomics - Tập 15 - Trang 1-10 - 2019
Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates have become a key tool for studying substrate use—yet an accurate model is required to analyse the complex data produced as these substrates become incorporated into the Krebs cycle. We aimed to g......
Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients
Metabolomics - Tập 11 - Trang 1626-1639 - 2015
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating long-term multisystem disorder with a central and inexplicably persistent fatigue symptom that is unable to be relieved by rest. Energy metabolism and oxidative stress have been recent focal points of ME/CFS research and in this study we were able to elucidate metabolic pathways that were indicative of their dysfunction.......
Metabolic targeted therapy of cancer: current tracer technologies and future drug design strategies in the old metabolic network
Metabolomics - Tập 1 - Trang 11-15 - 2005
Targeted drugs tailored against genes and signaling proteins have formed the new era termed Targeted Therapies. Although the field is relatively young, since only about 5 years ago clinical trials started showing promise, there have are already been significant setbacks due to drug resistance caused by point mutations, alterations in gene expression or complete loss of target proteins with disease......
Influence of preanalytical sampling conditions on the 1H NMR metabolic profile of human blood plasma and introduction of the Standard PREanalytical Code used in biobanking
Metabolomics - Tập 11 - Trang 1197-1207 - 2015
Variations in sample collection, processing and storage within the field of clinical metabolomics might hamper its effective implementation. In this study, the impact of relevant preanalytical conditions on the plasma 1H NMR metabolic profile was examined. The biobanking community recently developed a method for coding preanalytical conditions called the Standard PREanalytical Code (SPREC). It is ......
Breath metabolome of mice infected with Pseudomonas aeruginosa
Metabolomics - Tập 15 - Trang 1-10 - 2019
The measurement of specific volatile organic compounds in breath has been proposed as a potential diagnostic for a variety of diseases. The most well-studied bacterial lung infection in the breath field is that caused by Pseudomonas aeruginosa. To determine a discriminatory core of molecules in the “breath-print” of mice during a lung infection with four strains of P. aeruginosa (PAO1, PA14, PAK, ......
Influence of media selection on NMR based metabolic profiling of human cell lines
Metabolomics - Tập 14 - Trang 1-26 - 2018
Comparative metabolic profiling of different human cancer cell lines can reveal metabolic pathways up-regulated or down-regulated in each cell line, potentially providing insight into distinct metabolism taking place in different types of cancer cells. It is noteworthy, however, that human cell lines available from public repositories are deposited with recommended media for optimal growth, and if......
Tổng số: 1,382
- 1
- 2
- 3
- 4
- 5
- 6
- 10