Metabolomic signature of amino acids in plasma of patients with non-segmental VitiligoMetabolomics - Tập 17 - Trang 1-11 - 2021
Rezvan Marzabani, Hassan Rezadoost, Peyman Choopanian, Sima Kolahdooz, Nikoo Mozafari, Mehdi Mirzaie, Mehrdad Karimi, Anni I. Nieminen, Mohieddin Jafari
Vitiligo pathogenesis is complicated, and several possibilities were suggested.
However, it is well-known that the metabolism of pigments plays a significant
role in the pathogenicity of the disease. We explored the role of amino acids in
vitiligo using targeted metabolomics. The amino acid profile was studied in
plasma using liquid chromatography. First, 22 amino acids were derivatized and
precis... hiện toàn bộ
Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cellsMetabolomics - Tập 11 - Trang 71-80 - 2014
Qing-Yi Lu, Lifeng Zhang, Jennifer K. Yee, Vay-Liang W. Go, Wai-Nang Lee
Lactate dehydrogenase A (LDHA) is the enzyme that converts pyruvate to lactate
and oxidizes the reduced form of nicotinamide adenine dinucleotide to NAD+.
Several human cancers including the pancreas display elevated expression of
LDHA. Because of its essential role in cancer metabolism, LDHA has been
considered to be a potential target for cancer therapy. Recently, we have shown
that a green tea ... hiện toàn bộ
Discrimination of steatosis and NASH in mice using nuclear magnetic resonance spectroscopyMetabolomics - Tập 7 - Trang 237-246 - 2010
Matthias S. Klein, Christoph Dorn, Michael Saugspier, Claus Hellerbrand, Peter J. Oefner, Wolfram Gronwald
Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic
dysfunction. The disease spectrum ranges from hepatic steatosis to nonalcoholic
steatohepatitis (NASH). The aim of this study was to identify metabolic
differences in murine models of simple hepatic steatosis and NASH for the
distinction of these NAFLD stages. For 12 weeks, male BALB/c mice were fed
either a control or two diffe... hiện toàn bộ
A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolitesMetabolomics - Tập 15 - Trang 1-10 - 2019
Ross T. Lindsay, Demetris Demetriou, Dominic Manetta-Jones, James A. West, Andrew J. Murray, Julian L. Griffin
Relative oxidation of different metabolic substrates in the heart varies both
physiologically and pathologically, in order to meet metabolic demands under
different circumstances. 13C labelled substrates have become a key tool for
studying substrate use—yet an accurate model is required to analyse the complex
data produced as these substrates become incorporated into the Krebs cycle. We
aimed to g... hiện toàn bộ
Correction to: Short-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypassMetabolomics - - 2021
Gakyung Lee, Young Suk Park, Chamlee Cho, Hyunbeom Lee, Jin‐Young Park, Do Joong Park, Joo Ho Lee, Hyuk Joon Lee, Tae Kyung Ha, Yong Jin Kim, Seung Wan Ryu, Seunghee Han, Myoung-Woo Yoo, Sung Soo Park, Sang Uk Han, Yoonseok Heo, Byung Hwa Jung
Establishing a framework for best practices for quality assurance and quality control in untargeted metabolomicsMetabolomics - Tập 20 - Trang 1-13 - 2024
Jonathan D. Mosley, Tracey B. Schock, Chris W. Beecher, Warwick B. Dunn, Julia Kuligowski, Matthew R. Lewis, Georgios Theodoridis, Candice Z. Ulmer Holland, Dajana Vuckovic, Ian D. Wilson, Krista A. Zanetti
Quality assurance (QA) and quality control (QC) practices are key tenets that
facilitate study and data quality across all applications of untargeted
metabolomics. These important practices will strengthen this field and
accelerate its success. The Best Practices Working Group (WG) within the
Metabolomics Quality Assurance and Quality Control Consortium (mQACC) focuses on
community use of QA/QC pr... hiện toàn bộ