Metabolomics
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Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo
Metabolomics - Tập 17 - Trang 1-11 - 2021
Vitiligo pathogenesis is complicated, and several possibilities were suggested. However, it is well-known that the metabolism of pigments plays a significant role in the pathogenicity of the disease. We explored the role of amino acids in vitiligo using targeted metabolomics. The amino acid profile was studied in plasma using liquid chromatography. First, 22 amino acids were derivatized and precis......
Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cells
Metabolomics - Tập 11 - Trang 71-80 - 2014
Lactate dehydrogenase A (LDHA) is the enzyme that converts pyruvate to lactate and oxidizes the reduced form of nicotinamide adenine dinucleotide to NAD+. Several human cancers including the pancreas display elevated expression of LDHA. Because of its essential role in cancer metabolism, LDHA has been considered to be a potential target for cancer therapy. Recently, we have shown that a green tea ......
Influence of preanalytical sampling conditions on the 1H NMR metabolic profile of human blood plasma and introduction of the Standard PREanalytical Code used in biobanking
Metabolomics - Tập 11 - Trang 1197-1207 - 2015
Variations in sample collection, processing and storage within the field of clinical metabolomics might hamper its effective implementation. In this study, the impact of relevant preanalytical conditions on the plasma 1H NMR metabolic profile was examined. The biobanking community recently developed a method for coding preanalytical conditions called the Standard PREanalytical Code (SPREC). It is ......
Statistical measures for validating plant genotype similarity assessments following multivariate analysis of metabolome fingerprint data
Metabolomics - Tập 3 - Trang 349-355 - 2007
Metabolome fingerprinting offers opportunities for ‘first pass’ evaluation of compositional similarity between plant genotypes. Compositional “substantial equivalence” testing is a popular concept in the literature in relation to food safety; however reported studies do not provide a systematic and standard approach to quantify similarity in a high dimensional data context. We have undertaken a la......
SUMMER, a shiny utility for metabolomics and multiomics exploratory researchAbstract
Introduction
Cellular metabolites are generated by a complex network of biochemical reactions. This makes interpreting changes in metabolites exceptionally challenging.
Objectives
T... ...
Metabolomics - Tập 16 Số 12 - 2020
Non-target ROIMCR LC–MS analysis of the disruptive effects of TBT over time on the lipidomics of Daphnia magna
Metabolomics - Tập 19 - Trang 1-13 - 2023
This study has investigated the temporal disruptive effects of tributyltin (TBT) on lipid homeostasis in Daphnia magna. To achieve this, the study used Liquid Chromatography–Mass Spectrometry (LC–MS) analysis to analyze biological samples of Daphnia magna treated with TBT over time. The resulting data sets were multivariate and three-way, and were modeled using bilinear and trilinear non-negative ......
Identifying possible biomarkers of lower urinary tract symptoms using metabolomics and partial least square regressionAbstract
Introduction
The objective of this study was to explore potential novel biomarkers for moderate to severe lower urinary tract symptoms (LUTS) using a metabolomics-based approach, and statistical methods with significant different features than previous reported....
Metabolomics -
Mid- and long-term correlations of plasma metabolite concentrations measured by a targeted metabolomics approach
Metabolomics - Tập 12 - Trang 1-7 - 2016
Plasma metabolites measured by metabolomics techniques have been shown to be associated with chronic disease risk in epidemiological studies. However, in most prospective studies metabolomic profiles can only be obtained at a single time point and data on intra-individual variation in metabolite levels over time are sparse. Here, we evaluated the intra-individual variation in the concentrations of......
1H NMR-based metabolic profiling and target analysis: a combined approach for the quality control of Thymus vulgaris
Metabolomics - Tập 8 - Trang 335-346 - 2011
The characterization of T. vulgaris plant material for quality control purposes was performed by NMR-based methods. Direct extraction of 141 T. vulgaris samples with DMSO-d
6 enabled the obtainment of crude extracts with a representative composition in terms of both volatile and non-volatile constituents. The acquisition of 600 MHz 1H NMR spectra resulted in a dataset which was ana......
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