Metabolomics
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Comparative analysis of bioactive phytochemicals from Scutellaria baicalensis, Scutellaria lateriflora, Scutellaria racemosa, Scutellaria tomentosa and Scutellaria wrightii by LC-DAD-MS
Metabolomics - Tập 7 - Trang 446-453 - 2010
Scutellaria is a geographically widespread and diverse genus of the Lamiaceae family of herbaceous plants commonly known as skullcaps. Scutellaria is used widely as an ethnobotanical herb for the treatment of various ailments ranging from cancers, cirrhosis, jaundice, hepatitis, anxiety and nervous disorders. We used (1) reverse-phase liquid chromatography coupled to a diode array detector (LC-DAD......
Rumen fluid metabolomics of beef steers differing in feed efficiency
Metabolomics - Tập 16 Số 2 - 2020
Strategies for gathering structural information on unknown peaks in the GC/MS analysis of Corynebacterium glutamicum cell extracts
Metabolomics - Tập 1 Số 4 - Trang 317-324 - 2006
Metabolomic signature of amino acids in plasma of patients with non-segmental Vitiligo
Metabolomics - Tập 17 - Trang 1-11 - 2021
Vitiligo pathogenesis is complicated, and several possibilities were suggested. However, it is well-known that the metabolism of pigments plays a significant role in the pathogenicity of the disease. We explored the role of amino acids in vitiligo using targeted metabolomics. The amino acid profile was studied in plasma using liquid chromatography. First, 22 amino acids were derivatized and precis......
Metabolic consequences of LDHA inhibition by epigallocatechin gallate and oxamate in MIA PaCa-2 pancreatic cancer cells
Metabolomics - Tập 11 - Trang 71-80 - 2014
Lactate dehydrogenase A (LDHA) is the enzyme that converts pyruvate to lactate and oxidizes the reduced form of nicotinamide adenine dinucleotide to NAD+. Several human cancers including the pancreas display elevated expression of LDHA. Because of its essential role in cancer metabolism, LDHA has been considered to be a potential target for cancer therapy. Recently, we have shown that a green tea ......
Discrimination of steatosis and NASH in mice using nuclear magnetic resonance spectroscopy
Metabolomics - Tập 7 - Trang 237-246 - 2010
Nonalcoholic fatty liver disease (NAFLD) is a common cause of hepatic dysfunction. The disease spectrum ranges from hepatic steatosis to nonalcoholic steatohepatitis (NASH). The aim of this study was to identify metabolic differences in murine models of simple hepatic steatosis and NASH for the distinction of these NAFLD stages. For 12 weeks, male BALB/c mice were fed either a control or two diffe......
A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites
Metabolomics - Tập 15 - Trang 1-10 - 2019
Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates have become a key tool for studying substrate use—yet an accurate model is required to analyse the complex data produced as these substrates become incorporated into the Krebs cycle. We aimed to g......
Correction to: Short-term changes in the serum metabolome after laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass
Metabolomics - - 2021
Establishing a framework for best practices for quality assurance and quality control in untargeted metabolomics
Metabolomics - Tập 20 - Trang 1-13 - 2024
Quality assurance (QA) and quality control (QC) practices are key tenets that facilitate study and data quality across all applications of untargeted metabolomics. These important practices will strengthen this field and accelerate its success. The Best Practices Working Group (WG) within the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) focuses on community use of QA/QC pr......
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