Metabolic Brain Disease

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Influence of hippocampal GABAB receptor inhibition on memory in rats with acute β-amyloid toxicity
Metabolic Brain Disease - Tập 33 Số 6 - Trang 1859-1867 - 2018
Azam Almasi, Mohammad Zarei, Safoura Raoufi, Abdolrahman Sarihi, Iraj Salehi, Alireza Komaki‬, Nasrin Hashemi-Firouzi, Siamak Shahidi
Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP
Metabolic Brain Disease - Tập 38 - Trang 2615-2625 - 2023
Eduarda Monteiro Fidelis, Anne Suely P. Savall, Jhuly Dornelles Mello, Caroline Brandão Quines, Antônio Alvenir Comis-Neto, Tuane Bazanella Sampaio, Cristiane Casagrande Denardin, Daiana Silva de Ávila, Suzan Gonçalves Rosa, Simone Pinton
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely used due to its specific and reproducible neurotoxic effect on the nigrostriatal system, being considered a convenient model of dopaminergic neurodegeneration to study interventions therapeutics. The purple pitanga (Eugenia uniflora) is a polyphenol-rich fruit with antioxidant and antidepressant properties, among others. Therefore...... hiện toàn bộ
Autosomal dominant optic atrophy plus due to the novel OPA1 variant c.1463G>C
Metabolic Brain Disease - Tập 34 - Trang 1023-1027 - 2019
Josef Finsterer, Franco Laccone
OPA1 variants most frequently manifest phenotypically with pure autosomal dominant optic atrophy (ADOA) or with ADOA plus. The most frequent abnormalities in ADOA plus in addition to the optic nerve affection include hypoacusis, migraine, myopathy, and neuropathy. Hypertelorism and atrophy of the acoustic nerve have not been reported. The patient is a 48yo Caucasian female with slowly progressive,...... hiện toàn bộ
The antioxidant and neuroprotective effects of the Psychotria camptopus Verd. Hook. (Rubiaceae) stem bark methanol extract contributes to its antiepileptogenic activity against pentylenetetrazol kindling in male Wistar rats
Metabolic Brain Disease - Tập 36 - Trang 2015-2027 - 2021
Aliance Romain Fokoua, Abayomi Mayowa Ajayi, Benneth Ben-Azu, Rodolphe Chouna, Oluwabusayo Folarin, James Olopade, Pepin Alango Nkeng-Efouet, Adegbuyi Oladele Aderibigbe, Solomon Umukoro, Télesphore Benoît Nguelefack
A substantial number of epileptic patients are resistant to the current medication thus necessitating the search for alternative therapies for intractable forms of the disease. Previous studies demonstrated the acute anticonvulsant properties of the methanol extract of the stem bark of Psychotria camptopus (MEPC) in rats. This study investigated the effects of MEPC on pentylenetetrazole-kindled Wi...... hiện toàn bộ
Casein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injury
Metabolic Brain Disease - Tập 35 - Trang 1417-1428 - 2020
Ochuko L. Erukainure, Veronica F. Salau, Opeyemi O. Alabi, Osaretin A. T. Ebuehi, Neil A. Koorbanally, Md. Shahidul Islam
Caseins are the most abundant milk proteins in mammalian species and are assembled in supra-macromolecular structures called micelles. In this study, the microstructural properties, particle size, and elemental composition of isolated casein from bovine milk and its therapeutic effect on oxidative and cholinergic activities linked to dementia in oxidative brain injury were investigated. SEM analys...... hiện toàn bộ
Treatment outcome of creatine transporter deficiency: international retrospective cohort study
Metabolic Brain Disease - - 2018
Theodora Bruun, Sarah Sidky, Anabela Bandeira, F.G. Debray, Can Fıçıcıoğlu, Jennifer Goldstein, Kairit Joost, Dwight D. Koeberl, Luísa Diogo, Marie‐Cécile Nassogne, Siobhán O’Sullivan, Katrin Õunap, Andreas Schulze, Lionel Van Maldergem, Gajja S. Salomons, Saadet Mercimek‐Andrews
Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disability
Metabolic Brain Disease - Tập 31 - Trang 901-907 - 2016
Asem M. Alkhateeb, Samah K. Aburahma, Wesal Habbab, I. Richard Thompson
Intellectual disability is a heterogeneous disease with many genes and mutations influencing the phenotype. Consanguineous families constitute a rich resource for the identification of rare variants causing autosomal recessive disease, due to the effects of inbreeding. Here, we examine three consanguineous Arab families, recruited in a quest to identify novel genes/mutations. All the families had ...... hiện toàn bộ
Protective effect of resveratrol on citrullinemia type I-induced brain oxidative damage in male rats
Metabolic Brain Disease - Tập 36 - Trang 685-699 - 2021
Larissa Delmonego, Thayná Patachini Maia, Débora Delwing-Dal Magro, Karine Louize Vincenzi, Aline Barbosa Lima, Luana Carla Pscheidt, Letícia Eger, Daniela Delwing-de Lima
Citrullinemia Type I is an inborn error, which leads to accumulation of citrulline and ammonia in blood and body tissues. We evaluated the in vitro effects of citrulline, ammonia and the influence of resveratrol on oxidative stress parameters in the cerebrum of 30- and 60-day-old male Wistar rats. Citrulline (0.1, 2.5, 5.0 mM), ammonia (0.01, 0.1, 1.0 mM) and resveratrol (0.01, 0.1, 0.5 mM) were a...... hiện toàn bộ
Association between genetic variants and risk of obsessive-compulsive disorder
Metabolic Brain Disease - - 2022
Mohammad Taheri, Elham Badrlou, Bashdar Mahmud Hussen, Vahid Kholghi Oskooei, Seyedeh Morvarid Neishabouri, Soudeh Ghafouri‐Fard
Computational modelling approaches as a potential platform to understand the molecular genetics association between Parkinson’s and Gaucher diseases
Metabolic Brain Disease - Tập 33 - Trang 1835-1847 - 2018
D. Thirumal Kumar, Hend Ghasan Eldous, Zainab Alaa Mahgoub, C. George Priya Doss, Hatem Zayed
Gaucher’s disease (GD) is a genetic disorder in which glucocerebroside accumulates in cells and specific organs. It is broadly classified into type I, type II and type III. Patients with GD are at high risk of Parkinson’s disease (PD), and the clinical and pathological presentation of GD patients with PD is almost identical to idiopathic PD. Several experimental models like cell culture, animal mo...... hiện toàn bộ
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