Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTPMetabolic Brain Disease - Tập 38 - Trang 2615-2625 - 2023
Eduarda Monteiro Fidelis, Anne Suely P. Savall, Jhuly Dornelles Mello, Caroline Brandão Quines, Antônio Alvenir Comis-Neto, Tuane Bazanella Sampaio, Cristiane Casagrande Denardin, Daiana Silva de Ávila, Suzan Gonçalves Rosa, Simone Pinton
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely used due to its specific and reproducible neurotoxic effect on the nigrostriatal system, being considered a convenient model of dopaminergic neurodegeneration to study interventions therapeutics. The purple pitanga (Eugenia uniflora) is a polyphenol-rich fruit with antioxidant and antidepressant properties, among others. Therefore...... hiện toàn bộ
Autosomal dominant optic atrophy plus due to the novel OPA1 variant c.1463G>CMetabolic Brain Disease - Tập 34 - Trang 1023-1027 - 2019
Josef Finsterer, Franco Laccone
OPA1 variants most frequently manifest phenotypically with pure autosomal dominant optic atrophy (ADOA) or with ADOA plus. The most frequent abnormalities in ADOA plus in addition to the optic nerve affection include hypoacusis, migraine, myopathy, and neuropathy. Hypertelorism and atrophy of the acoustic nerve have not been reported. The patient is a 48yo Caucasian female with slowly progressive,...... hiện toàn bộ
Casein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injuryMetabolic Brain Disease - Tập 35 - Trang 1417-1428 - 2020
Ochuko L. Erukainure, Veronica F. Salau, Opeyemi O. Alabi, Osaretin A. T. Ebuehi, Neil A. Koorbanally, Md. Shahidul Islam
Caseins are the most abundant milk proteins in mammalian species and are assembled in supra-macromolecular structures called micelles. In this study, the microstructural properties, particle size, and elemental composition of isolated casein from bovine milk and its therapeutic effect on oxidative and cholinergic activities linked to dementia in oxidative brain injury were investigated. SEM analys...... hiện toàn bộ
Novel mutations in WWOX, RARS2, and C10orf2 genes in consanguineous Arab families with intellectual disabilityMetabolic Brain Disease - Tập 31 - Trang 901-907 - 2016
Asem M. Alkhateeb, Samah K. Aburahma, Wesal Habbab, I. Richard Thompson
Intellectual disability is a heterogeneous disease with many genes and mutations influencing the phenotype. Consanguineous families constitute a rich resource for the identification of rare variants causing autosomal recessive disease, due to the effects of inbreeding. Here, we examine three consanguineous Arab families, recruited in a quest to identify novel genes/mutations. All the families had ...... hiện toàn bộ
Protective effect of resveratrol on citrullinemia type I-induced brain oxidative damage in male ratsMetabolic Brain Disease - Tập 36 - Trang 685-699 - 2021
Larissa Delmonego, Thayná Patachini Maia, Débora Delwing-Dal Magro, Karine Louize Vincenzi, Aline Barbosa Lima, Luana Carla Pscheidt, Letícia Eger, Daniela Delwing-de Lima
Citrullinemia Type I is an inborn error, which leads to accumulation of citrulline and ammonia in blood and body tissues. We evaluated the in vitro effects of citrulline, ammonia and the influence of resveratrol on oxidative stress parameters in the cerebrum of 30- and 60-day-old male Wistar rats. Citrulline (0.1, 2.5, 5.0 mM), ammonia (0.01, 0.1, 1.0 mM) and resveratrol (0.01, 0.1, 0.5 mM) were a...... hiện toàn bộ
Predicting which patients with cirrhosis will develop overt hepatic encephalopathy: Beyond psychometric testingMetabolic Brain Disease - Tập 38 - Trang 1701-1706 - 2022
Zachary M. Saleh, Elliot B. Tapper
It remains challenging to identify covert hepatic encephalopathy and predict progression to overt hepatic encephalopathy. Psychometric testing is a widely used diagnostic modality, but it is often inaccurate and difficult to implement in diverse populations, making it a less than ideal assessment. Alternatively, by using easily accessible data from the electronic health record, simple clinical ass...... hiện toàn bộ