Metabolic Brain Disease

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Influence of hippocampal GABAB receptor inhibition on memory in rats with acute β-amyloid toxicity
Metabolic Brain Disease - Tập 33 Số 6 - Trang 1859-1867 - 2018
Azam Almasi, Mohammad Zarei, Safoura Raoufi, Abdolrahman Sarihi, Iraj Salehi, Alireza Komaki‬, Nasrin Hashemi-Firouzi, Siamak Shahidi
Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP
Metabolic Brain Disease - Tập 38 - Trang 2615-2625 - 2023
Eduarda Monteiro Fidelis, Anne Suely P. Savall, Jhuly Dornelles Mello, Caroline Brandão Quines, Antônio Alvenir Comis-Neto, Tuane Bazanella Sampaio, Cristiane Casagrande Denardin, Daiana Silva de Ávila, Suzan Gonçalves Rosa, Simone Pinton
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely used due to its specific and reproducible neurotoxic effect on the nigrostriatal system, being considered a convenient model of dopaminergic neurodegeneration to study interventions therapeutics. The purple pitanga (Eugenia uniflora) is a polyphenol-rich fruit with antioxidant and antidepressant properties, among others. Therefore...... hiện toàn bộ
Nuclear prelamin a recognition factor and iron dysregulation in multiple sclerosis
Metabolic Brain Disease - Tập 35 - Trang 275-282 - 2019
Di Ding, Anddre Osmar Valdivia, Sanjoy K. Bhattacharya
Dysregulation of iron metabolism and aberrant iron deposition has been associated with multiple sclerosis. However, the factors that contribute to this pathological state remain to be understood. In this study, human multiple sclerosis and mice brain samples were analyzed through mass spectrometry as well as histological and immunoblot techniques, which demonstrated that iron deposition is associa...... hiện toàn bộ
Autosomal dominant optic atrophy plus due to the novel OPA1 variant c.1463G>C
Metabolic Brain Disease - Tập 34 - Trang 1023-1027 - 2019
Josef Finsterer, Franco Laccone
OPA1 variants most frequently manifest phenotypically with pure autosomal dominant optic atrophy (ADOA) or with ADOA plus. The most frequent abnormalities in ADOA plus in addition to the optic nerve affection include hypoacusis, migraine, myopathy, and neuropathy. Hypertelorism and atrophy of the acoustic nerve have not been reported. The patient is a 48yo Caucasian female with slowly progressive,...... hiện toàn bộ
Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features
Metabolic Brain Disease - Tập 38 - Trang 2817-2829 - 2023
Huijie Yuan, Zhaoyao Luo, Wen Gu, Shaohui Ma, Guangyu Li, Dun Ding, Xueying Ma, Peng Li, Jing Yang, Xiaoling Xu, Junya Mu, Ming Zhang
End-stage kidney disease and mild cognitive impairment (ESKD-MCI) affect the quality of life and long-term treatment outcomes of patients affected by these diseases. Clarifying the morphological changes from brain injuries in ESKD-MCI and their relationship with clinical features is helpful for the early identification and intervention of MCI before it progresses to irreversible dementia. This stu...... hiện toàn bộ
The antioxidant and neuroprotective effects of the Psychotria camptopus Verd. Hook. (Rubiaceae) stem bark methanol extract contributes to its antiepileptogenic activity against pentylenetetrazol kindling in male Wistar rats
Metabolic Brain Disease - Tập 36 - Trang 2015-2027 - 2021
Aliance Romain Fokoua, Abayomi Mayowa Ajayi, Benneth Ben-Azu, Rodolphe Chouna, Oluwabusayo Folarin, James Olopade, Pepin Alango Nkeng-Efouet, Adegbuyi Oladele Aderibigbe, Solomon Umukoro, Télesphore Benoît Nguelefack
A substantial number of epileptic patients are resistant to the current medication thus necessitating the search for alternative therapies for intractable forms of the disease. Previous studies demonstrated the acute anticonvulsant properties of the methanol extract of the stem bark of Psychotria camptopus (MEPC) in rats. This study investigated the effects of MEPC on pentylenetetrazole-kindled Wi...... hiện toàn bộ
Casein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injury
Metabolic Brain Disease - Tập 35 - Trang 1417-1428 - 2020
Ochuko L. Erukainure, Veronica F. Salau, Opeyemi O. Alabi, Osaretin A. T. Ebuehi, Neil A. Koorbanally, Md. Shahidul Islam
Caseins are the most abundant milk proteins in mammalian species and are assembled in supra-macromolecular structures called micelles. In this study, the microstructural properties, particle size, and elemental composition of isolated casein from bovine milk and its therapeutic effect on oxidative and cholinergic activities linked to dementia in oxidative brain injury were investigated. SEM analys...... hiện toàn bộ
Treatment outcome of creatine transporter deficiency: international retrospective cohort study
Metabolic Brain Disease - - 2018
Theodora Bruun, Sarah Sidky, Anabela Bandeira, F.G. Debray, Can Fıçıcıoğlu, Jennifer Goldstein, Kairit Joost, Dwight D. Koeberl, Luísa Diogo, Marie‐Cécile Nassogne, Siobhán O’Sullivan, Katrin Õunap, Andreas Schulze, Lionel Van Maldergem, Gajja S. Salomons, Saadet Mercimek‐Andrews
Bio-ecological control of chronic liver disease and encephalopathy
Metabolic Brain Disease - - 2008
Stig Bengmark
Minimal encephalopathy was originally associated with chronic liver disease but is increasingly associated with most other chronic diseases and particularly with diabetes and also chronic disorders in other organs: kidneys, lungs, thyroid and with obesity. It is increasingly with dramatically increased and more or less permanent increase in systemic inflammation, most likely a result of Western li...... hiện toàn bộ
Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats
Metabolic Brain Disease - Tập 35 - Trang 1279-1286 - 2020
Rupsa Ghosh, Susmita Sil, Pritha Gupta, Tusharkanti Ghosh
Intracerebroventricular (ICV) injection of streptozotocin (STZ) is a well established procedure to induce neuroinflammation leading to dementia in experimental animals. However, the optimal dose of STZ has not been determined. In the present study, rats were ICV injected with 1.5, 3 and 6 mg of STZ per kg of body weight. After 21 days, neuroinflammatory markers i.e. TNF-α, IL-1β, ROS and nitrite w...... hiện toàn bộ
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