Liver International
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Distinguishing nonalcoholic steatohepatitis from fatty liver: serum‐free fatty acids, insulin resistance, and serum lipoproteinsAbstract: Objectives: The prognosis of nonalcoholic fatty liver disease is determined by liver biopsy; steatohepatitis can be progressive whereas fatty liver is benign. Insulin resistance and increased hepatic‐free fatty acids are central to the pathophysiology of this disorder. Our objective was to assess whether serum‐free fatty acids, lipoproteins, and insulin re...
Liver International - Tập 26 Số 5 - Trang 566-571 - 2006
Periodontitis is associated with incident chronic liver disease—A population‐based cohort studyAbstract Background & Aims Chronic liver disease is a major health concern worldwide and the identification of novel modifiable risk factors may benefit subjects at risk. Few studies have analyzed periodontitis as a risk factor for liver complications. We studied whether periodontitis is associated with incident severe liver dis...
Liver International - Tập 39 Số 3 - Trang 583-591 - 2019
The value of different CT‐based methods for diagnosing low muscle mass and predicting mortality in patients with cirrhosisAbstract Background & Aims Low muscle mass impacts on morbidity and mortality in cirrhosis. The skeletal‐muscle index (SMI) is a well‐validated tool to diagnose muscle wasting, but requires specialized radiologic software and expertise. Thus, we compared different Computed tomography (CT)‐based evaluation methods for muscle wast...
Liver International - Tập 39 Số 12 - Trang 2374-2385 - 2019
Evaluating the association of serum ferritin and hepatic iron with disease severity in non‐alcoholic fatty liver diseaseAbstract Background & Aims Hyperferritinemia, with or without increased hepatic iron, represents a common finding in non‐alcoholic fatty liver disease (NAFLD ). However, it is unclear whether it reflects hepatic inflammation or true iron‐overload and, in case the latte...
Liver International - Tập 39 Số 7 - Trang 1325-1334 - 2019
The combination of liver stiffness measurement and NAFLD fibrosis score improves the noninvasive diagnostic accuracy for severe liver fibrosis in patients with nonalcoholic fatty liver diseaseAbstract Background & Aims The accuracy of noninvasive tools for the diagnosis of severe fibrosis in patients with nonalcoholic fatty liver disease(NAFLD ) in clinical practice is still limited. We aimed at assessing the diagnostic performance of combined noninvasive t...
Liver International - Tập 35 Số 5 - Trang 1566-1573 - 2015
Effect of platelet‐activating factor (PAF) receptor antagonist (BN52021) on acetaminophen‐induced acute liver injury and regeneration in ratsAbstract:
Background: Platelet‐activating factor (PAF) is an endogenous lipid mediator that plays a key role in catalyzing various pro‐inflammatory processes associated with acute liver injury. In the present study, the possible influence of PAF‐R antagonist (BN52021) on the protection of liver injury after 4‐hydroxyacetanilide, N ‐ace...
Liver International - Tập 26 Số 1 - Trang 97-105 - 2006
Single‐centre validation of the EASL ‐CLIF Consortium definition of acute‐on‐chronic liver failure and CLIF ‐SOFA for prediction of mortality in cirrhosisAbstract Background & Aims The idea of acute‐on‐chronic liver failure (ACLF ) has emerged to identify those subjects with organ failure and high mortality rates. However, the absence of a precise definition has limited the clinical application and research related to t...
Liver International - Tập 35 Số 5 - Trang 1516-1523 - 2015
Controlled attenuation parameter does not predict hepatic decompensation in patients with advanced chronic liver diseaseAbstract Background & Aims Assessment of hepatic steatosis by transient elastography (TE)‐based controlled attenuation parameter (CAP) might predict hepatic decompensation. Therefore, we aimed to evaluate the prognostic value of CAP in patients with compensated advanced chronic liver disease (cACLD) and decompensated cirrhosis (...
Liver International - Tập 39 Số 1 - Trang 127-135 - 2019
Analysis of factors associated with discrepancies between predicted and observed liver weight in liver transplantationAbstract Background Even using predictive formulas based on anthropometrics in about 30% of subjects, liver weight (LW) cannot be predicted with a ≤20% margin of error. We aimed to identify factors associated with discrepancies between predicted and observed LW. Methods In...
Liver International - Tập 41 Số 6 - Trang 1379-1388 - 2021
MuRF ‐1 and p‐GSK 3β expression in muscle atrophy of cirrhosisAbstract Background Chronic diseases, including cirrhosis, are often accompanied by protein‐energy malnutrition and muscle loss, which in turn negatively affect quality of life, morbidity and mortality. Unlike other chronic conditions, few data are available on the molecular mechanisms underlying muscle wasting in this clinical sett...
Liver International - Tập 33 Số 5 - Trang 714-721 - 2013
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