Hepatitis C virus incidence in <scp>HIV</scp>‐infected and in preexposure prophylaxis (PrEP)‐using men having sex with men

Liver International - Tập 38 Số 10 - Trang 1736-1740 - 2018
Laurent Cotte1,2, Éric Cua3, Jacques Reynes4,5, F. Raffi6,7, David Rey8, Pierre Delobel9,10,11, Amandine Gagneux‐Brunon12, Christine Jacomet13, Romain Palich14, Hélène Laroche15,16,17, André Cabie18,19,20, Bruno Hoën21,22,23, Christian Chidiac1,24, Pierre Pradat25
1Department of Infectious Diseases, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France
2Inserm U1052, Lyon, France
3Department of Infectious Diseases, Hôpital l'Archet, Centre Hospitalier Universitaire de Nice, Nice, France
4Department of Infectious Diseases, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
5INSERM U1175 UMI 233 Université de Montpellier Montpellier France
6Department of Infectious Diseases, Hotel-Dieu Hospital, Centre Hospitalier Universitaire de Nantes, Nantes, France
7INSERM CIC 1413, Nantes, France
8HIV Infection Care Centre, Hôpitaux Universitaires, Strasbourg, France
9Department of Infectious Diseases, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
10INSERM, UMR1043, Toulouse, France
11Université Toulouse III Paul Sabatier, Toulouse, France;
12Department of Infectious Diseases, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, France
13Department of Infectious Diseases, Centre Hospitalier Universitaire de Clermont-Ferrand, Clermont-Ferrand, France
14Department of Infectious Diseases Pitié‐Salpêtrière Hospital Assistance Publique ‐ Hôpitaux de Paris Paris France
15Aix Marseille University, Marseille France
16INSERM, U912 (SESSTIM), Marseille, France
17Service d'Immuno‐Hématologie Clinique APHM Hôpital Sainte‐Marguerite Marseille France
18Department of Infectious Diseases, Centre Hospitalier Universitaire de Martinique, Fort de France, France
19INSERM CIC1424 Fort‐de‐France France
20Université des Antilles EA4537 Fort de France France
21Faculté de Médecine Hyacinthe Bastaraud Université des Antilles Pointe‐à‐Pitre France
22INSERM CIC 1424 Pointe‐à‐Pitre France
23Service de Maladies Infectieuses et Tropicales Dermatologie et Médecine Interne Centre Hospitalier Universitaire de Pointe‐à‐Pitre Pointe‐à‐Pitre France
24Université Claude Bernard Lyon 1, Lyon, France
25Center for Clinical Research, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France

Tóm tắt

AbstractBackground & AimsHCV incidence still appears on the rise in HIV‐infected MSM in France. We assessed the incidence of HCV infection in HIV‐positive and in preexposure prophylaxis (PrEP)‐using MSM.MethodsHIV‐infected, HCV‐negative MSM with serological follow‐up in 2016 and HIV‐negative, HCV‐negative PrEP‐using MSM enrolled from January 2016 to May 2017 in the French Dat’AIDS cohort were analysed to assess the incidence of a primary HCV infection. The incidence of HCV reinfection was also determined in patients having cured a previous infection.ResultsAmong 10 049 HIV‐infected MSM followed in 2016, 681 patients were already HCV‐infected when entering the study (prevalence 6.8%). Serological follow‐up was available in 2016 for 4151 HCV‐negative patients. Virological follow‐up was available for 478 patients who had cured a previous infection. Fifty‐seven HCV infections occurred in 2016 (42 primary infections, 15 reinfections). Incidence of primary HCV infection, reinfection and overall HCV infection was, respectively, 1.0, 3.1 and 1.2/100 person‐years (PY). From January 2016 to May 2017, 930 HIV‐negative subjects were enrolled for PrEP. Seventeen patients were already HCV‐infected (prevalence 1.8%). Twelve HCV infections occurred during follow‐up (10 primary infections, 2 reinfections) giving an incidence of primary infection of 1.0/100 PY and an overall incidence of 1.2/100 PY.ConclusionsThe overall incidence of HCV infection and of a primary HCV infection in HIV‐positive and in PrEP‐using MSM appeared similar in France in 2016 to early 2017. HIV‐positive and PrEP‐using MSM probably share similar at‐risk practices and both should be targeted for preventative interventions.

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Tài liệu tham khảo

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Liver International

Tập 38 Số 10

1736-1740

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