Effects of prenatal hypoxia on expression of amyloid precursor protein and metallopeptidases in the rat brainLetters in Peptide Science - Tập 10 - Trang 455-462 - 2003
Natalia N. Nalivaeva, Lilia Fisk, Rosa M. Canet. Aviles, Svetlana A. Plesneva, Igor A. Zhuravin, Anthony J. Turner
In the present study we have investigated the effect of prenatal hypoxia on expression of amyloid precursor protein (APP) and some metallopeptidases, which regulate β-amyloid peptide (Aβ) levels (neprilysin (NEP) and endothelin-converting enzyme (ECE-1)) in the cortex of rats during different periods of postnatal development. We have found that the level of APP in the sensorimotor cortex (SMC) of ...... hiện toàn bộ
Base-induced side reactions in Fmoc-solid phase peptide synthesis:Minimization by use of piperazine as Nα-deprotectionreagentLetters in Peptide Science - Tập 7 - Trang 107-112 - 2000
John D. Wade, Marc N. Mathieu, Mary Macris, Geoffrey W. Tregear
Base-induced aspartimide (cyclic imide) and subsequentbase adduct formation in the Fmoc-solid phasesynthesis of sensitive sequences are serious sidereactions that are difficult to both anticipate andcontrol. The effect of extended treatment ofpiperazine as Nα-Fmoc deprotection reagenton two sensitive peptide sequences was examined. Forcomparison, other bases were also investigated,including piperi...... hiện toàn bộ
An optimized Boc synthesis of indolicidinLetters in Peptide Science - Tập 4 Số 1 - Trang 41-48 - 1997
Andreu, David, García, Francisco Javier
Indolicidin, an antimicrobial peptide from bovine neutrophils containing five tryptophan out of a total of 13 residues, has the highest molar proportion of tryptophan of any known peptide sequence and is thus considered a difficult synthetic target. Conventional Boc chemistry can be applied to the synthesis of indolicidin with an appropriate choice of scavenger mixtures, reaction times and tempera...... hiện toàn bộ
A rapid coupling protocol for the synthesis of peptide nucleic acidsLetters in Peptide Science - Tập 9 - Trang 211-219 - 2002
Christopher J. Vearing, John V. Fecondo
With the current interest in anti-sense and anti-gene technologies, an efficient, fast and less toxic synthesis protocol would be advantageous for the oligomerisation of Peptide Nucleic Acids (PNA). Most of the methods currently in use for the t-Boc synthesis of PNA's use TFA/m-cresol, pyridine, piperidine and capping reagents. In this work, a rapid synthesis protocol has been adapted from an earl...... hiện toàn bộ
Novel naphthoquinonyl derivatives: Potential structural components for the synthesis of cytotoxic peptidesLetters in Peptide Science - Tập 3 - Trang 263-274 - 1996
Shai Rahimipour, Lev Weiner, Mati Fridkin, Prativa Bade Shrestha-Dawadi, Shmuel Bittner
Syntheses and physicochemical properties are described of several novel naphthoquinonyl amino acid derivatives, which are potential components in cytotoxic peptide conjugates. These compounds include N
ε- and N
α-naphthoquinonyl derivatives of lysine as well as N-naphthoquinonyl-carboxylic derivatives. The former class of compounds can be employed as building blocks in a stepwise peptide synthesis...... hiện toàn bộ
Role of A β and the α 7 nicotinic acetylcholine receptor in regulating synaptic plasticity in Alzheimer's diseaseLetters in Peptide Science - Tập 10 - Trang 401-404 - 2003
David H. Small, Lisa R. Fodero, Dusan Losic, Cindy Chu, Marie-Isabel Aguilar, Lisandra L. Martin, Mary Chebib
Alzheimer's disease (AD) is caused by the accumulation of β-amyloid protein (Aβ) in the brain. The aggregation of β-amyloid protein to higher molecular weight fibrillar forms is also considered to be an important step in the pathogenesis of the disease. The memory problems associated with AD are likely to be caused by changes in synaptic plasticity. Recent studies suggest that Aβ binds to the α 7 ...... hiện toàn bộ
Application of conformationally restricted peptidomimetics to modeling the bound conformation of peptide antagonists with the IL-1 receptorLetters in Peptide Science - Tập 5 - Trang 93-100 - 1998
Gary A. Flynn, Ann L. Akeson, Ram Dharanipragada, Michael J. Genin, J. Antony Malikayil, Richard Pottorf, Jeffery S. Sabol, Herman Schreuder, Ron Tomlinson, Phil Waid, Ron Barrett, Jeff Jacobs, Steve Yanofsky
A collection of complementary peptide caricatures that closely mimic low-energy (presumably highly populated) conformations of amino acids of interest would constitute a valuable tool set to study the interactions of small peptide ligands with their biological targets. Our general strategy for the design, synthesis and application of peptidomimetics is presented. An illustration of how structural ...... hiện toàn bộ
Membrane destabilization induced by the human immunodeficiency virus type-1 fusion peptideLetters in Peptide Science - Tập 4 - Trang 365-369 - 1997
José L. Nieva, Félix M. Goñi, Arturo Muga, Shlomo Nir, Francisca Pereira
The human immunodeficiency virus type-1 (HIV-1) fusionpeptide, corresponding to a sequence of 23 amino acidresidues at the N-terminus of the spike transmembranesubunit gp41, has the capacity to destabilizenegatively charged and neutral large unilamellarvesicles, representing, respectively, the acidic andthe neutral fraction of the plasma membrane lipids ofviral target cells. As revealed by infrare...... hiện toàn bộ