Journals of Gerontology - Series A Biological Sciences and Medical Sciences
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Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 73 Số 1 - Trang 29-38 - 2018
An Outreach Rehabilitation Program for Nursing Home Residents After Hip Fracture May Be Cost-Saving Abstract Background We compared the cost-effectiveness of 10 weeks of outreach rehabilitation (intervention) versus usual care (control) for ambulatory nursing home residents after hip fracture. Methods Enrollment occurred February 2011 through June 2015 in a Canadian metropolitan region. Seventy-seven participants were allocated in a 2:1 ratio to receive a 10-week rehabilitation program (intervention) or usual care (control) (46 intervention; 31 control). Using a payer perspective, we performed main and sensitivity analyses. Health outcome was measured by quality-adjusted life years (QALYs), using the EQ5D, completed at study entry, 3-, 6-, and 12-months. We obtained patient-specific data for outpatient visits, physician claims, and inpatient readmissions; the trial provided rehabilitation utilization/cost data. We estimated incremental cost and incremental effectiveness. Results Groups were similar at study entry; the mean age was 87.9 ± 6.6 years, 54 (71%) were female and 58 (75%) had severe cognitive impairment. EQ5D QALYs scores were nonsignificantly higher for intervention participants. Inpatient readmissions were two times higher among controls, with a cost difference of −$3,350/patient for intervention participants, offsetting the cost/intervention participant of $2,300 for the outreach rehabilitation. The adjusted incremental QALYs/patient difference was 0.024 favoring the intervention, with an incremental cost/patient of −$621 for intervention participants; these values were not statistically significant. A sensitivity analysis reinforced these findings, suggesting that the intervention was likely dominant. Conclusion A 10-week outreach rehabilitation intervention for nursing home residents who sustain a hip fracture may be cost-saving, through reduced postfracture hospital readmissions. These results support further work to evaluate postfracture rehabilitation for nursing home residents.
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 75 Số 10 - Trang e159-e165 - 2020
Caloric Restriction Decreases Age-Dependent Accumulation of the Glycoxidation Products, Nisin-(Carboxymethyl)lysine and Pentosidine, in Rat Skin Collagen
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 50A Số 6 - Trang B337-B341 - 1995
A Study of Caloric Restriction and Cardiovascular Aging in Cynomolgus Monkeys (Macacafascicularis): A Potential Model for Aging Research
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 52A Số 1 - Trang B10-B19 - 1997
Life-Span Extension by Caloric Restriction Is Determined by Type and Level of Food Reduction and by Reproductive Mode in Brachionus manjavacas (Rotifera)
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 68 Số 4 - Trang 349-358 - 2013
Aging Biology and Novel Targets for Drug Discovery
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 67A Số 2 - Trang 168-174 - 2012
Fear of Falling Predicts Incidence of Functional Disability 2 Years Later: A Perspective From an International Cohort Study
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 73 Số 9 - Trang 1212-1215 - 2018
Frailty in Older Adults: A Nationally Representative Profile in the United States
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 70 Số 11 - Trang 1427-1434 - 2015
Polypharmacy in Nursing Home in Europe: Results From the SHELTER Study
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 67A Số 6 - Trang 698-704 - 2012
Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study Abstract
Background
Prolonged sitting is common in older adults and is associated with insulin resistance and poor cardiometabolic health. We investigate whether breaking prolonged sitting with regular short bouts of standing or light walking improves postprandial metabolism in older white European and South Asian adults and whether effects are modified by ethnic group.
Methods
Thirty South Asian (15 women) and 30 white European (14 women) older adults (aged 65–79 years) undertook three experimental conditions in random order. (a) Prolonged sitting: continuous sitting during an observation period if 7.5 hours consuming two standardized mixed meals. (b) Standing breaks: sitting interrupted with 5 minutes of standing every 30 minutes (accumulating 60 minutes of standing over the observation period). (c) Walking breaks: sitting interrupted with 5 minutes of self-paced light walking every 30 minutes (accumulating 60 minutes of walking). Blood samples (glucose, insulin, triglycerides) and blood pressure were sampled regularly throughout each condition.
Results
Compared with prolonged sitting, walking breaks lowered postprandial insulin by 16.3 mU/L, (95% CI: 19.7, 22.0) with greater reductions (p = .029) seen in South Asians (22.4 mU/L; 12.4, 32.4) than white Europeans (10.3 mU/L; 5.9, 14.7). Glucose (0.3 mmol/L; 0.1, 0.5) and blood pressure (4 mm Hg; 2, 6), but not triglycerides, were lower with walking breaks, with no ethnic differences. Standing breaks did not improve any outcome.
Conclusions
Breaking prolonged sitting with short bouts of light walking, but not standing, resulted in clinically meaningful improvements in markers of metabolic health in older adults, with South Asians gaining a greater reduction in postprandial insulin.
Trial Registration
NCT02453204
Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 75 Số 1 - Trang 139-146 - 2020
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