Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort

Journals of Gerontology - Series A Biological Sciences and Medical Sciences - Tập 75 Số 11 - Trang 2224-2230 - 2020
Janice L. Atkins1, Jane Masoli2,1, João Delgado1, Luke C. Pilling3,1, Chia‐Ling Kuo3, George A. Kuchel3, David Melzer3,1
1Epidemiology and Public Health Group, University of Exeter Medical School, UK
2Department of Healthcare for Older People, Royal Devon and Exeter Hospital, UK
3Center on Aging, University of Connecticut Health Center, Farmington

Tóm tắt

AbstractBackgroundHospitalized COVID-19 patients tend to be older and frequently have hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true risk factors (ie, more common than in the general older population) is unclear. We estimated associations between preexisting diagnoses and hospitalized COVID-19 alone or with mortality, in a large community cohort.MethodsUK Biobank (England) participants with baseline assessment 2006–2010, followed in hospital discharge records to 2017 and death records to 2020. Demographic and preexisting common diagnoses association tested with hospitalized laboratory-confirmed COVID-19 (March 16 to April 26, 2020), alone or with mortality, in logistic models.ResultsOf 269 070 participants aged older than 65, 507 (0.2%) became COVID-19 hospital inpatients, of which 141 (27.8%) died. Common comorbidities in hospitalized inpatients were hypertension (59.6%), history of fall or fragility fractures (29.4%), coronary heart disease (21.5%), type 2 diabetes (type 2, 19. 9%), and asthma (17.6%). However, in models adjusted for comorbidities, age group, sex, ethnicity, and education, preexisting diagnoses of dementia, type 2 diabetes, chronic obstructive pulmonary disease, pneumonia, depression, atrial fibrillation, and hypertension emerged as independent risk factors for COVID-19 hospitalization, the first 5 remaining statistically significant for related mortality. Chronic kidney disease and asthma were risk factors for COVID-19 hospitalization in women but not men.ConclusionsThere are specific high-risk preexisting comorbidities for COVID-19 hospitalization and related deaths in community-based older men and women. These results do not support simple age-based targeting of the older population to prevent severe COVID-19 infections.

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Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Tập 75 Số 11

2224-2230

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