Journal of the Peripheral Nervous System
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Journal of the Peripheral Nervous System - Tập 25 Số 2 - Trang 204-207 - 2020
AbstractAcute demyelinating inflammatory polyneuropathy (AIDP) is the most
common type of Guillain‐Barré syndrome (GBS) in Europe, following several viral
and bacterial infections. Data on AIDP‐patients associated with SARS‐CoV‐2
(coronavirus‐2) infection are scarce. We describe the case of a 54‐years‐old
Caucasian female patient with typical clinical and electrophysiological
manifestations of AID...
Reliability of the CMT neuropathy score (second version) in Charcot‐Marie‐Tooth disease
Journal of the Peripheral Nervous System - Tập 16 Số 3 - Trang 191-198 - 2011
The Charcot‐Marie‐Tooth neuropathy score (CMTNS) is a reliable and valid
composite score comprising symptoms, signs, and neurophysiological tests, which
has been used in natural history studies of CMT1A and CMT1X and as an outcome
measure in treatment trials of CMT1A. Following an international workshop on
outcome measures in Charcot‐Marie‐Tooth disease (CMT), the CMTNS was modified to
attempt to ...
Sensory neuronopathies: A case series and literature review
Journal of the Peripheral Nervous System - Tập 26 Số 1 - Trang 66-74 - 2021
AbstractSensory neuronopathies are heterogeneous disorders of dorsal root
ganglia. The clinical and laboratory features in a single‐centre series,
including response to treatment and outcome have been described. They
retrospectively included 54 patients meeting Camdessanché et al (2009) criteria
for sensory neuronopathy. The patients were classified according to their likely
aetiology and analysed...
“Red‐flag” symptom clusters in transthyretin familial amyloid polyneuropathy
Journal of the Peripheral Nervous System - Tập 21 Số 1 - Trang 5-9 - 2016
AbstractTransthyretin familial amyloid polyneuropathy (TTR‐FAP) is a rare,
progressive, life‐threatening, hereditary disorder caused by mutations in the
transthyretin gene and characterized by extracellular deposition of
transthyretin‐derived amyloid fibrils in peripheral and autonomic nerves, heart,
and other organs. TTR‐FAP is frequently diagnosed late because the disease is
difficult to recogni...
Idiopathic neuropathy: new paradigms, new promise
Journal of the Peripheral Nervous System - Tập 17 Số s2 - Trang 43-49 - 2012
Idiopathic neuropathy, now designated as chronic idiopathic axonal
polyneuropathy (CIAP), is a major public health problem in the United States.
The disorder affects an estimated 5–8 million Americans, comprising about
one‐third of patients with neuropathy, based on data from referral centers.
Typically, patients develop symptoms in the sixth decade or older. The onset is
insidious, with numbness,...
A clinical pattern‐based etiological diagnostic strategy for sensory neuronopathies: a French collaborative study
Journal of the Peripheral Nervous System - Tập 17 Số 3 - Trang 331-340 - 2012
Sensory neuronopathies (SNNs) encompass paraneoplastic, infectious, dysimmune,
toxic, inherited, and idiopathic disorders. Recently described diagnostic
criteria allow SNN to be differentiated from other forms of sensory neuropathy,
but there is no validated strategy based on routine clinical investigations for
the etiological diagnosis of SNN. In a multicenter study, the clinical,
biological, and...
Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy
Journal of the Peripheral Nervous System - Tập 22 Số 3 - Trang 162-171 - 2017
AbstractDistal axon degeneration seen in many peripheral neuropathies is likely
to share common molecular mechanisms with Wallerian degeneration. Although
several studies in mouse models of peripheral neuropathy showed prevention of
axon degeneration in the slow Wallerian degeneration (Wlds) mouse, the role of a
recently identified player in Wallerian degeneration, Sarm1, has not been
explored ext...
Modulation of diet‐induced mechanical allodynia by metabolic parameters and inflammation
Journal of the Peripheral Nervous System - Tập 22 Số 1 - Trang 39-46 - 2017
AbstractDietary‐associated diseases have increased tremendously in our current
population, yet key molecular changes associated with high‐fat diets that cause
clinical pre‐diabetes, obesity, hyperglycemia, and peripheral neuropathy remain
unclear. This study examines molecular and metabolic aspects altered by
voluntary exercise and a high‐fat diet in the mouse dorsal root ganglion. Mice
were exami...
Long‐term outcome of Guillain‐Barré syndrome in children
Journal of the Peripheral Nervous System - Tập 19 Số 2 - Trang 121-126 - 2014
AbstractThe objective of this study is to determine the long‐term outcome and
consequences of Guillain‐Barré syndrome (GBS) in children. This is an
observational cross‐sectional cohort study of children diagnosed with GBS
(0–18 years old) at the Sophia Children's Hospital in Rotterdam from 1987 to
2009. All patients were invited for a structured interview, questionnaires, and
full neurologic exam ...
Sciatic inflammatory neuritis (SIN): Behavioral allodynia is paralleled by peri‐sciatic proinflammatory cytokine and superoxide production
Journal of the Peripheral Nervous System - Tập 6 Số 3 - Trang 111-129 - 2001
Abstract We have recently developed a model of sciatic inflammatory neuritis
(SIN) to assess how immune activation near peripheral nerves influences
somatosensory processing. Administration of zymosan (yeast cell walls) around a
single sciatic nerve produces dose‐dependent low‐threshold mechanical allodynia
without thermal hyperalgesia. Low (4 μg) doses produce both territorial and
extraterritori...
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