Journal of bioenergetics
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The α/β Interfaces of α1β1, α3β3, and F1: Domain Motions and Elastic Energy Stored during γ Rotation
Journal of bioenergetics - Tập 32 - Trang 471-484 - 2000
ATP synthase (FoF1) consists of F1 (ATP-driven motor) and Fo (H+-driven motor). F1 is a complex of α3β3γδε subunits, and γ is the rotating cam in α3β3. Thermophilic F1 (TF1) is exceptional in that it can be crystallized as a β monomer and an α3β3 oligomer, and it is sufficiently stable to allow αβ refolding and reassembly of hybrid complexes containing 1, 2, and 3 modified α or β. The nucleotide-d......
Protein translocationin vitro: Biochemical characterization of genetically defined translocation components
Journal of bioenergetics - Tập 22 - Trang 369-387 - 1990
Recent years have seen the convergence of both genetic and biochemical approaches in the study of protein translocation inE. coli. The powerful combination of these approaches is exemplified in the use of anin vitro protein synthesis-protein translocaltion system to analyze the role of genetically defined components of the protein translocation machinery. We describe in this review recent results ......
New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT
Journal of bioenergetics - Tập 50 Số 3 - Trang 231-240 - 2018
O-GlcNAcylation is a dynamic and functionally diverse post-translational modification shown to affect thousands of proteins, including the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (Nod2). Mutations of Nod2 (R702W, G908R and 1007 fs) are associated with Crohn’s disease and have lower stabilities compared to wild type. Cycloheximide (CHX)-chase half-life ......
Glutamate Interacts with VDAC and Modulates Opening of the Mitochondrial Permeability Transition Pore
Journal of bioenergetics - Tập 36 - Trang 179-186 - 2004
The amino acid glutamate, synthesized in the mitochondria, serves multiple functions, including acting as a neurotransmitter and participating in degradative and synthetic pathways. We have previously shown that glutamate modulates the channel activity of bilayer-reconstituted voltage-dependent anion channel (VDAC). In this study, we demonstrate that glutamate also modulates the opening of the mit......
The inhibitors of antioxidant cell enzymes induce permeability transition in yeast mitochondria
Journal of bioenergetics - Tập 45 - Trang 491-504 - 2013
In this study we investigated the effects of exogenous and endogenous oxidative stress on mitochondrial membrane permeability transition in yeast cells. E. magnusii yeast was used in the study as it is the only yeast strain possessing a natural high-capacity Са2+ transport system. The key reactive oxygen species (ROS) detoxifying enzymes in the yeast cells - catalases (CATs) and superoxide dismuta......
The mechanism of lead-induced mitochondrial Ca2+ efflux
Journal of bioenergetics - Tập 19 - Trang 285-295 - 1987
Addition of Pb2+ to rat kidney mitochondria is followed by induction of several reactions: inhibition of Ca2+ uptake, collapse of the transmembrane potential, oxidation of pyridine nucleotides, and a fast release of accumulated Ca2+. When the incubation media are supplemented with ruthenium red, the effect of Pb2+ on NAD(P)H oxidation, membrane ΔΨ, and Ca2+ release are not prevented if malate-glut......
O-GlcNAc: a novel regulator of immunometabolism
Journal of bioenergetics - Tập 50 - Trang 223-229 - 2018
The rapidly expanding field of immunometabolism focuses on how metabolism controls the function of immune cells. CD4+ T cells are essential for the adaptive immune response leading to the eradication of specific pathogens. However, when T cells are inappropriately over-active, they can drive autoimmunity, allergic disease, and chronic inflammation. The mechanisms by which metabolic changes influen......
Electron transfer in ruthenium-modified proteins
Journal of bioenergetics - Tập 27 - Trang 295-302 - 1995
Photochemical techniques have been used to measure the kinetics of intramolecular electron transfer in Ru(bpy)2(im)(His)2+-modified (bpy = 2,2′-bipyridine; im = imidazole) cytochromec and azurin. A driving-force study with the His33 derivatives of cytochromec indicates that the reorganization energy (γ) for Fe2+→Ru3+ ET reactions is 0.8 eV. Reductions of the ferriheme by either an excited complex,......
Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis
Journal of bioenergetics - Tập 52 - Trang 1-15 - 2019
Schizophrenia etiology is unknown, nevertheless imbalances occurring in an acute psychotic episode are important to its development, such as alterations in cellular energetic state, REDOX homeostasis and intracellular Ca2+ management, all of which are controlled primarily by mitochondria. However, mitochondrial function was always evaluated singularly, in the presence of specific respiratory subst......
Nhiệt độ thấp làm thay đổi thành phần lipid màng plasma và hoạt động ATPase của trái dứa trong quá trình phát triển bệnh đen lòng Dịch bởi AI
Journal of bioenergetics - Tập 46 - Trang 59-69 - 2014
Màng plasma (PM) đóng vai trò trung tâm trong việc kích hoạt các phản ứng ban đầu với tổn thương do lạnh và duy trì sự cân bằng tế bào. Việc đặc trưng phản ứng của lipid màng đối với nhiệt độ thấp có thể cung cấp thông tin quan trọng để xác định các yếu tố nguyên nhân sớm góp phần gây ra tổn thương do lạnh. Để làm điều này, thành phần lipid màng PM và hoạt động ATPase được đánh giá trong trái dứa ......
#màng plasma #lipid #hoạt động ATPase #dứa #bệnh đen lòng #nhiệt độ thấp
Tổng số: 1,745
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