Journal of bioenergetics
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The α/β Interfaces of α1β1, α3β3, and F1: Domain Motions and Elastic Energy Stored during γ Rotation
Journal of bioenergetics - Tập 32 - Trang 471-484 - 2000
ATP synthase (FoF1) consists of F1 (ATP-driven motor) and Fo (H+-driven motor). F1 is a complex of α3β3γδε subunits, and γ is the rotating cam in α3β3. Thermophilic F1 (TF1) is exceptional in that it can be crystallized as a β monomer and an α3β3 oligomer, and it is sufficiently stable to allow αβ refolding and reassembly of hybrid complexes containing 1, 2, and 3 modified α or β. The nucleotide-d......
URF13, a ligand-gated, pore-forming receptor for T-toxin in the inner membrane ofcms-T mitochondria
Journal of bioenergetics - Tập 27 Số 4 - Trang 437-445 - 1995
Protein translocationin vitro: Biochemical characterization of genetically defined translocation components
Journal of bioenergetics - Tập 22 - Trang 369-387 - 1990
Recent years have seen the convergence of both genetic and biochemical approaches in the study of protein translocation inE. coli. The powerful combination of these approaches is exemplified in the use of anin vitro protein synthesis-protein translocaltion system to analyze the role of genetically defined components of the protein translocation machinery. We describe in this review recent results ......
Genetic strategies for dissecting mammalian and Drosophila voltage-dependent anion channel functions
Journal of bioenergetics - Tập 40 - Trang 207-212 - 2008
Voltage-dependent anion channels (VDACs), also known as mitochondrial porins, are a family of small pore-forming proteins of the mitochondrial outer membrane that are found in all eukaryotes. VDACs are thought to play important roles in the regulated flux of metabolites between the cytosolic and mitochondrial compartments, in overall energy metabolism via interactions with cytosolic kinases, and a......
Phosphate transport in mitochondria and submitochondrial particles: The influence of thiol oxidation
Journal of bioenergetics - Tập 9 - Trang 203-212 - 1977
Diamide, a thiol oxidizing agent, partially inhibited P
i
uptake by rat liver mitochondria. The inhibition was temperature dependent; at 20°C, the optimal temperature for maximum inhibitory effect, diamide also reduced the minimal amount of mersalyl required for the inhibition of P
i
transport. Under the same conditions no inhib......
MiR-703 protects against hypoxia/reoxygenation-induced cardiomyocyte injury via inhibiting the NLRP3/caspase-1-mediated pyroptosis
Journal of bioenergetics - Tập 52 - Trang 155-164 - 2020
Myocardial infarction represents one of the severe cardiovascular diseases and is one of the high-risk factors for mortality, and ischemia/reperfusion (I/R) injury is one of the risk factors that contribute to the high mortality of myocardial infarction. MicroRNAs have been proven as key regulators in various diseases including myocardial infarction. The present study was sought to determine the r......
New use for CETSA: monitoring innate immune receptor stability via post-translational modification by OGT
Journal of bioenergetics - Tập 50 Số 3 - Trang 231-240 - 2018
O-GlcNAcylation is a dynamic and functionally diverse post-translational modification shown to affect thousands of proteins, including the innate immune receptor nucleotide-binding oligomerization domain-containing protein 2 (Nod2). Mutations of Nod2 (R702W, G908R and 1007 fs) are associated with Crohn’s disease and have lower stabilities compared to wild type. Cycloheximide (CHX)-chase half-life ......
Glutamate Interacts with VDAC and Modulates Opening of the Mitochondrial Permeability Transition Pore
Journal of bioenergetics - Tập 36 - Trang 179-186 - 2004
The amino acid glutamate, synthesized in the mitochondria, serves multiple functions, including acting as a neurotransmitter and participating in degradative and synthetic pathways. We have previously shown that glutamate modulates the channel activity of bilayer-reconstituted voltage-dependent anion channel (VDAC). In this study, we demonstrate that glutamate also modulates the opening of the mit......
The Contribution of Mitochondrial Respiratory Complexes to the Production of Reactive Oxygen Species
Journal of bioenergetics - Tập 32 - Trang 153-162 - 2000
This work was focused on distinguishing the contribution of mitochondrial redox complexesto the production of reactive oxygen species (ROS) during cellular respiration. We were ableto accurately measure, for the first time, the basal production of ROS under uncoupled conditionsby using a very sensitive method, based on the fluorescent probe dichlorodihydrofluoresceindiacetate. The method also enab......
The inhibitors of antioxidant cell enzymes induce permeability transition in yeast mitochondria
Journal of bioenergetics - Tập 45 - Trang 491-504 - 2013
In this study we investigated the effects of exogenous and endogenous oxidative stress on mitochondrial membrane permeability transition in yeast cells. E. magnusii yeast was used in the study as it is the only yeast strain possessing a natural high-capacity Са2+ transport system. The key reactive oxygen species (ROS) detoxifying enzymes in the yeast cells - catalases (CATs) and superoxide dismuta......
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