Journal of Viral Hepatitis

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Hepatitis C virus and the brain
Journal of Viral Hepatitis - Tập 19 Số 5 - Trang 301-306 - 2012
Nicola F. Fletcher, Jane A. McKeating
Summary.  Hepatitis C virus (HCV) is an enveloped, positive‐strand RNA virus of the family Flaviviridae that primarily infects hepatocytes, causing acute and chronic liver disease. HCV is also associated with a variety of extrahepatic symptoms including central nervous system (CNS) abnormalities, cognitive dysfunction, fatigue and depression. These symptoms do not co...... hiện toàn bộ
Incidence of Hepatitis A in Argentina after vaccination
Journal of Viral Hepatitis - Tập 15 Số s2 - Trang 47-50 - 2008
M Vacchino
Summary.  In Argentina, the annual incidence rate of reported hepatitis A disease ranged from 70.5 to 173.8 per 100 000 during 1995–2004. A single dose universal hepatitis A immunization program aimed at children aged 12 months was started in June 2005. The aim was to observe the impact of universal vaccination against hepatitis A in Argentina. A longitudinal analysi...... hiện toàn bộ
Impact of viral hepatitis aetiology on survival outcomes in hepatocellular carcinoma: A large multicentre cohort study
Journal of Viral Hepatitis - Tập 24 Số 11 - Trang 982-989 - 2017
S. Mgaieth, William Kemp, Paul Gow, Michael Fink, John Lubel, Amanda Nicoll, Alessia Gazzola, Thai Hong, Marno Ryan, Virginia Knight, Anouk Dev, Siddharth Sood, Sally Bell, Eldho Paul, Stuart K. Roberts
SummaryWhile HBV and HCV are risk factors for HCC, uncertainty exists as to whether these viral infections have prognostic significance in HC...... hiện toàn bộ
Hepatitis B surface antigen loss and sustained viral suppression in Asian chronic hepatitis B patients: A community‐based real‐world study
Journal of Viral Hepatitis - Tập 24 Số 12 - Trang 1089-1097 - 2017
Robert J. Wong, Mai Thanh Thi Nguyen, Huy N. Trinh, C. K. Chan, Andrew Huynh, M. T. Ly, Huy Nguyen, Khanh K. Nguyen, Sharon Torres, J. Yang, B. Liu, Ruel T. Garcia, Taft Bhuket, Rachel Baden, Brian S. Levitt, Eduardo Silveira, Robert G. Gish
SummaryCommunity‐based real‐world outcomes on effectiveness of antiviral therapies for chronic hepatitis B virus (CHB) in Asians are limited. Whether hepatitis B surface antigen (HBsAg) loss correlates with undetectable virus and alanine amino...... hiện toàn bộ
Cytokine profile of peripheral blood mononuclear cells from patients with different outcomes of hepatitis C virus infection
Journal of Viral Hepatitis - Tập 12 Số 5 - Trang 525-530 - 2005
Annagiulia Gramenzi, Pietro Andreoné, E. Loggi, Francesco Giuseppe Foschi, C. Cursaro, Marzia Margotti, Maurizio Biselli, M. Bernardi
Summary.  The relationship between the balance of helper T‐cell type 1 (Th1) or type 2 (Th2) cytokines and the clinical course of hepatitis C virus (HCV) infection is unclear. We evaluated Th1 [interleukin (IL)‐2, interferon‐gamma (IFN‐γ)] and Th2 cytokine (IL‐4, IL‐10) and 2,5‐oligoadenylate synthetase (OAS, an IFN‐induced antiviral protei...... hiện toàn bộ
Community‐based real‐world treatment outcomes of sofosbuvir/ledipasvir in Asians with chronic hepatitis C virus genotype 6 in the United States
Journal of Viral Hepatitis - Tập 24 Số 1 - Trang 17-21 - 2017
Robert J. Wong, Mai Thanh Thi Nguyen, Huy N. Trinh, Andrew Huynh, M. T. Ly, Huy Nguyen, Khanh K. Nguyen, J.C. Yang, Ruel T. Garcia, Brian S. Levitt, Eduardo Silveira, Robert G. Gish
SummarySofosbuvir/ledipasvir (SOF/LDV) is the first all‐oral ribavirin‐free treatment approved for chronic hepatitis C virus (HCV) genotype 6, offering a safe and highly efficacious...... hiện toàn bộ
Biochemical and structural analysis of the NS5B RNA‐dependent RNA polymerase of the hepatitis C virus
Journal of Viral Hepatitis - Tập 7 Số 3 - Trang 167-174 - 2000
Volker Lohmann, G Roos, Körner, André Koch, Ralf Bartenschlager
Hepatitis C virus (HCV), the major causative agent of chronic and sporadic non‐A, non‐B hepatitis worldwide, is a distinct member of the Flaviviridae virus family. These viruses have in common a plus‐strand RNA genome that is replicated in the cytoplasm of the infected cell via minus‐strand RNA intermediates. Owing to the lack of reliable cell culture systems and...... hiện toàn bộ
A placebo‐controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection
Journal of Viral Hepatitis - Tập 6 Số 5 - Trang 387-395 - 1999
Richard Gilson, Kapil Chopra, A Newell, I M Murray-Lyon, Mark Nelson, S J Rice, Richard S. Tedder, John J. Toole, H S Jaffe, Ian Weller
Adefovir dipivoxil (bis‐POM PMEA) is an adenine nucleotide analogue with activity against retroviruses and herpesviruses, and in vitro activity against hepatitis B virus (HBV). This study was conducted to evaluate its safety and antiviral activity in patients with chronic HBV infection. Twenty patients (13 co‐infected with human immunodeficiency virus, HIV) were ...... hiện toàn bộ
Antigen‐specific T lymphocyte proliferation decreases over time in advanced chronic hepatitis C
Journal of Viral Hepatitis - Tập 19 Số 6 - Trang 404-413 - 2012
Chihiro Morishima, Adrian M. Di Bisceglie, Alan L. Rothman, Herbert L. Bonkovsky, Karen L. Lindsay, W. M. Lee, Margaret James Koziel, Robert J. Fontana, H.‐Y. Kim, Elizabeth C. Wright
Summary.  To evaluate T cell immunity in advanced liver disease, antigen‐specific lymphoproliferative (LP) responses were prospectively studied in the context of the Hepatitis C Antiviral Long‐term Treatment against Cirrhosis trial. Peripheral blood responses to hepatitis C virus (HCV), tetanus and Candida protein antigens were measured at ...... hiện toàn bộ
Increased effective immunogenicity to high‐dose and short‐interval hepatitis B virus vaccination in individuals with chronic hepatitis without cirrhosis
Journal of Viral Hepatitis - Tập 8 Số 5 - Trang 372-376 - 2001
Nicola De Maria, Ramazan İdilman, A. Colantoni, David H. Van Thiel
Hepatitis B virus (HBV) vaccination is recommended for individuals with chronic liver disease. However, the response to standard doses of hepatitis B vaccines in such individuals has been poor. The aim of the present study was to assess the response to high‐dose short‐interval HBV vaccination in individuals with chronic liver disease of different aetiologies. A total two hundred and 24 sub...... hiện toàn bộ
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