Journal of Viral Hepatitis
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Prevention of allograft HCV recurrence with peri‐transplant human monoclonal antibody MBL ‐HCV 1 combined with a single oral direct‐acting antiviral: A proof‐of‐concept study
Journal of Viral Hepatitis - Tập 24 Số 3 - Trang 197-206 - 2017
SummaryPatients with active hepatitis C virus (HCV) infection at transplantation
experience rapid allograft infection, increased risk of graft failure and
accelerated fibrosis. MBL‐HCV1, a neutralizing human monoclonal antibody (mAb)
targeting the HCV envelope, was combined with a licensed oral direct‐acting
antiviral (DAA) to prevent HCV recurrence post‐transplant in an open‐label
exploratory eff...
Hepatitis C virus infection: a risk factor for P arkinson's disease
Journal of Viral Hepatitis - Tập 22 Số 10 - Trang 784-791 - 2015
SummaryRecent studies found that hepatitis C virus (HCV) may invade the central
nervous system, and both HCV and Parkinson's disease (PD) have in common the
overexpression of inflammatory biomarkers. We analysed data from a
community‐based integrated screening programme based on a total of 62 276
subjects. We used logistic regression models to investigate association between
HCV infection and PD. ...
Association between viral hepatitis infection and Parkinson's disease: A population‐based prospective study
Journal of Viral Hepatitis - Tập 27 Số 11 - Trang 1171-1178 - 2020
AbstractThe association between hepatitis virus infection and Parkinson's
disease remains controversial. To determine whether hepatitis B virus (HBV) and
hepatitis C virus (HCV) infections are associated with an increased risk of
Parkinson's disease in Korean aged ≥40 years, we completed a population‐based
prospective study including patients without infections and those with HBV, HCV
and HBV/HCV ...
Modulation of the anti‐inflammatory interleukin 10 and of proapoptotic IL‐18 in patients with chronic hepatitis C treated with interferon alpha and ribavirin
Journal of Viral Hepatitis - Tập 13 Số 4 - Trang 230-234 - 2006
Summary. The aim of this work was to analyse apoptosis rate, measured by the
serum levels of proapoptotic interleukin (IL)‐18 and of soluble Fas (sFas), as
well as of anti‐inflammatory IL‐10, in patients with chronic hepatitis C, at
baseline and after treatment with interferon alpha and ribavirin. Twenty‐seven
patients with biopsy‐proven chronic hepatitis C were studied, at baseline and
after tre...
Hepatitis C virus and the brain
Journal of Viral Hepatitis - Tập 19 Số 5 - Trang 301-306 - 2012
Summary. Hepatitis C virus (HCV) is an enveloped, positive‐strand RNA virus of
the family Flaviviridae that primarily infects hepatocytes, causing acute and
chronic liver disease. HCV is also associated with a variety of extrahepatic
symptoms including central nervous system (CNS) abnormalities, cognitive
dysfunction, fatigue and depression. These symptoms do not correlate with the
severity of li...
Incidence of Hepatitis A in Argentina after vaccination
Journal of Viral Hepatitis - Tập 15 Số s2 - Trang 47-50 - 2008
Summary. In Argentina, the annual incidence rate of reported hepatitis A
disease ranged from 70.5 to 173.8 per 100 000 during 1995–2004. A single dose
universal hepatitis A immunization program aimed at children aged 12 months was
started in June 2005. The aim was to observe the impact of universal vaccination
against hepatitis A in Argentina. A longitudinal analysis of hepatitis A rates
reported...
Impact of viral hepatitis aetiology on survival outcomes in hepatocellular carcinoma: A large multicentre cohort study
Journal of Viral Hepatitis - Tập 24 Số 11 - Trang 982-989 - 2017
SummaryWhile HBV and HCV are risk factors for HCC, uncertainty exists as to
whether these viral infections have prognostic significance in HCC. Thus, we
compared the overall survival of patients with HBV, HCV and nonviral HCC, and
evaluated whether the presence of HBV and HCV predicts patient outcomes. We
conducted a multicentre study of HCC cases diagnosed at six Melbourne tertiary
hospitals betw...
Hepatitis B surface antigen loss and sustained viral suppression in Asian chronic hepatitis B patients: A community‐based real‐world study
Journal of Viral Hepatitis - Tập 24 Số 12 - Trang 1089-1097 - 2017
SummaryCommunity‐based real‐world outcomes on effectiveness of antiviral
therapies for chronic hepatitis B virus (CHB) in Asians are limited. Whether
hepatitis B surface antigen (HBsAg) loss correlates with undetectable virus and
alanine aminotransferase (ALT) normalization on treatment or what predicts risk
of seroreversion or detectable virus after stopping therapy is unclear. We aim
to evaluate...
Association of TNF‐alpha promoter polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han population
Journal of Viral Hepatitis - Tập 13 Số 9 - Trang 618-624 - 2006
Summary. Host genetic factors and environment factors including hepatitis B
virus (HBV) genotypes are widely studied for the different outcomes of HBV
infection. Recent studies suggest that tumour necrosis factor‐alpha (TNF‐alpha)
plays a pivotal role in the viral clearance and host immune response to HBV, and
the capacity for TNF‐alpha production in individuals is influenced by a major
genetic c...
Cytokine profile of peripheral blood mononuclear cells from patients with different outcomes of hepatitis C virus infection
Journal of Viral Hepatitis - Tập 12 Số 5 - Trang 525-530 - 2005
Summary. The relationship between the balance of helper T‐cell type 1 (Th1) or
type 2 (Th2) cytokines and the clinical course of hepatitis C virus (HCV)
infection is unclear. We evaluated Th1 [interleukin (IL)‐2, interferon‐gamma
(IFN‐γ)] and Th2 cytokine (IL‐4, IL‐10) and 2,5‐oligoadenylate synthetase (OAS,
an IFN‐induced antiviral protein) production by peripheral blood mononuclear
cells from 1...
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