A review of chronic hepatitis B epidemiology and management issues in selected countries in the Middle East

Journal of Viral Hepatitis - Tập 19 Số 1 - Trang 9-22 - 2012

Tóm tắt

Summary. Experts from seven countries convened as a Specialist Panel for the Middle East to share information on practical issues relating to the epidemiology, diagnosis and management of chronic hepatitis B (CHB) infection. The Middle East is regarded as a region of high‐to‐intermediate epidemicity; however, infant vaccination programmes have successfully lowered the prevalence of hepatitis B infection in most countries to that of low‐to‐intermediate endemicity. Vaccine issues still to be addressed included improving coverage in some rural/poor communities, instituting hepatitis B vaccine at birth and providing vaccines for high‐risk population groups. Hepatitis B infection in the Middle East primarily occurs as a result of perinatal infection, horizontal transmission between family members and transmission from injections. Blood transfusion services have broadly efficient screening programmes, but immunocompromised and haemodialysis patients are at risk. The cost of screening, monitoring and treating CHB influences practice in a number of Middle East countries, and there is a need for information on the most cost‐effective options.

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Tài liệu tham khảo

World Health Organization.Hepatitis B. Fact sheet No. 204. [Updated Aug 2008] Available at:http://www.who.int/mediacentre/factsheets/fs204/en/(accessed 8 November 2010).

10.1016/j.cld.2007.08.002

World Health Organization Europe, 2007, HIV/AIDS Treatment and Care. Clinical protocols for the WHO European Region

Qirbi N, 2001, Epidemiology of hepatitis B virus infection in the Middle East, East Mediterr Health J, 7, 1034, 10.26719/2001.7.6.1034

10.1016/S0035-9203(97)90070-5

Mohamed MK, 2004, Epidemiology of HCV in Egypt 2004, Afro-Arab Liver J, 3, 41

10.1023/A:1025805817101

El‐Gilany AH, 2006, Bloodborne infections among student voluntary blood donors in Mansoura University, Egypt, East Mediterr Health J, 12, 742

Zakaria S, 2005, A community‐based study of viral hepatitis infection in Giza Governorate, Egypt: Seroprevalence, risk factors and associated morbidity, Med J Cairo Univ, 73, 899

10.1111/j.1365-3148.2007.00806.x

Alavian SM, 2008, Hepatitis B virus infection in Iran: a systematic review, Hepat Mon, 8, 281

Alizadeh AHM, 2006, Seroprevalence of hepatitis B in Nahavand, Islamic Republic of Iran, East Mediterr Health J, 12, 528

Kasraian L, 2007, Prevalence of major transfusion‐transmissible viral infections in blood donors attending Fars Blood Transfusion Center, Shiraz, southern Iran: 2002–05, Iran J Med Sci, 32, 114

Doosti A, 2009, Prevalence of viral hepatitis and molecular analysis of HBV among voluntary blood donors in west Iran, New Microbiol, 32, 193

Khedmat H, 2009, Trends in seroprevalence of hepatitis B, hepatitis C, HIV, and syphilis infections in Iranian blood donors from 2003 to 2005, Hepat Mon, 9, 24

10.3923/pjbs.2007.4461.4466

Merat S, 2009, The prevalence of hepatitis B surface antigen and anti‐hepatitis B core antibody in Iran: a population‐based study, Arch Iran Med, 12, 225

Nokhodlan Z, 2009, Hepatitis B markers in Isfahan, Central Iran: a population‐based study, Hepat Mon, 9, 12

10.1016/0035-9203(76)90144-9

Al‐Rashed M, 2003, The prevalence of hepatitis B in blood donors in the middle region of Jordan, Gulhane Med J, 45, 153

10.1111/j.1537-2995.2005.00635.x

Saab BR, 2007, Prevalence of hepatitis B in a presumably healthy Lebanese population, J Med Liban, 55, 11

10.1016/j.ajic.2005.06.009

Baddoura R, 2002, Hepatitis B and C seroprevalence in the Lebanese population, East Mediterr Health J, 8, 150, 10.26719/2002.8.1.150

10.1017/S0950268805003948

10.1016/j.jinf.2005.05.006

10.1016/j.ijid.2006.10.004

Khokhar N, 2004, General seroprevalence of hepatitis C and hepatitis B virus infections in population, J Coll Physicians Surg Pak, 14, 534

10.1186/1471-2334-6-101

10.1111/j.1537-2995.2007.01066.x

Butt T, 2008, Seroprevalence of hepatitis B and C infections among young adult males in Pakistan, East Mediterr Health J, 14, 791

10.1186/1471-2334-7-64

10.1186/1471-2334-8-43

Sheikh SM, 2009, Hepatitis B and C: value of universal antenatal screening, J Coll Physicians Surg Pak, 19, 179

Fawzi Z, 2007, Survey of hepatitis markers among donors in the State of Qatar, Qatar Med J, 16, 47

10.1016/S0163-4453(99)90245-1

Tamimi W, 2003, Expansion of Saudi blood donor pool by better screening and vaccination practices, Clin Diagn Lab Immunol, 10, 1159

10.1111/j.1365-2257.2004.00601.x

Khalil MKM, 2005, Serosurvey of hepatitis B surface antigen in pregnant Saudi women, East Mediterr Health J, 11, 640

10.1016/j.ijid.2008.01.010

10.1016/j.jinf.2008.08.008

Othman BM, 2001, Prevalence of hepatitis C virus antibodies among health care workers in Damascus, Syria, Saudi Med J, 22, 603

10.1007/s10654-006-0001-2

Mehmet D, 2005, Prevalence of hepatitis B infection in the southeastern region of Turkey: comparison of risk factors for HBV infection in rural and urban areas, Jpn J Infect Dis, 58, 15, 10.7883/yoken.JJID.2005.15

Güven R, 2006, Hepatitis B prevalence among workers in Turkey at low risk for hepatitis B exposure, East Mediterr Health J, 12, 749

Alim A, 2009, Seroprevalence of hepatitis B and C viruses, HIV, and syphilis infections among engaged couples, Saudi Med J, 30, 541

10.1016/j.ijid.2008.07.005

Yildirim B, 2009, Seroprevalence of hepatitis B and C viruses in the province of Tokat in the Black Sea region of Turkey: a population‐based study, Turk J Gastroenterol, 20, 27

Dikici B, 2009, Prevalence of hepatitis B infection among schoolchildren in southeast Turkey, Turk J Med Sci, 39, 289

Al‐Owais A, 2000, Use of existing data for public health planning: a study of the prevalence of hepatitis B surface antigen and core antibody in Al Ain Medical District, United Arab Emirates, Bull World Health Organ, 78, 1324

Haidar NA, 2002, Prevalence of hepatitis B and hepatitis C in blood donors and high risk groups in Hajjah, Yemen Republic, Saudi Med J, 23, 1090

Al‐Nassiri KA, 2001, Hepatitis B infection in Yemenis in Sana’a: pattern and risk factors, East Mediterr Health J, 7, 147, 10.26719/2001.7.1-2.147

Bajubair MA, 2008, Hepatic viral infections in Yemen between 2000–2005, Saudi Med J, 29, 871

10.1017/S0950268803008653

United Nations Secretariat.Population Division of the Department of Economic and Social Affairs. World Population Prospects: the 2008 Revision. Annex Table A1. Available at:http://www.un.org/esa/population/publications/wpp2008/wpp2008_text_tables.pdf(accessed 8 November 2010).

10.1016/j.trstmh.2005.12.003

10.1016/j.ijid.2005.04.007

10.1086/511074

10.1016/0928-4346(94)00175-5

10.3748/wjg.14.1510

10.3748/wjg.14.7231

Khokhar N, 2005, Treatment of chronic hepatitis B with lamivudine, J Coll Physicians Surg Pak, 15, 78

Mumtaz K, 2011, A study of genotypes, mutants and nucleotide sequencing of Hepatitis B virus in Pakistan, Hepat Mon, 11, 14

10.3748/wjg.v12.i43.7019

10.3748/wjg.v11.i13.1976

10.1136/pgmj.2006.044826

10.1002/jmv.10427

Idrees M, 2004, Common genotypes of hepatitis B virus, J Coll Physicians Surg Pak, 14, 344

10.1186/1471-2334-7-115

Hajeer AH, 2007, Hepatitis B virus: a study of genotypes in an infected Saudi cohort, Br J Biomed Sci, 64, 93, 10.1080/09674845.2007.11978099

Al Ashgar HI, 2008, Prevalence of hepatitis B virus genotype in Saudi Arabia: a preliminary report, Indian J Gastroenterol, 27, 81

Aksoy A, 2006, Hepatit B virusunun restriksiyon enzim analizi ile tiplendirilmesi [Genotyping of hepatitis B virus by restriction enzyme analysis], Mikrobiyol Bul, 40, 215

Ozdemir FT, 2005, Determination of hepatitis B genotypes in patients with chronic hepatitis B virus infection in Turkey, Turk J Gastroenterol, 16, 183

Liu C‐J, 2006, Clinical implication of chronic hepatitis B genotype, Hepatol Rev, 3, 33

10.1056/NEJMoa043470

10.1002/hep.1840400407

10.1038/sj.bjc.6603649

10.1023/A:1010705910858

El‐Zayadi AR, 2005, Hepatocellular carcinoma in Egypt: a single center study over a decade, World J Gastroenterol, 11, 5193

10.1111/j.1440-1746.2003.03334.x

Abdo AA, 2006, Histological and laboratory features of patients undergoing liver biopsy at a university hospital in Central Saudi Arabia, Saudi Med J, 27, 1493

10.1016/j.cld.2007.08.005

10.1002/hep.23190

10.1007/s12072-008-9080-3

Al AmiriAH.The strategy for eliminating HBV. Transmission through blood transfusion in United Arab Emirates. Presented at First International Qatar Hepatitis Symposium. Doha Qatar: 16–17 December 2005.

Khokhar N, 2004, Hepatitis B surface antigenemia in patients on haemodialysis, Rawal Med J, 29, 18

10.3748/wjg.v11.i3.418

10.1017/S0950268807008011

10.1038/sj.ph.1900684

10.1186/1471-230X-5-26

10.1016/S0140-6736(04)17458-8

10.1016/j.puhe.2006.05.004

Shazi L, 2006, Comparison of risk factors for hepatitis B and C in patients visiting a gastroenterology clinic, J Coll Physicians Surg Pak, 16, 104

10.3923/jms.2006.222.224

10.1038/sj.thj.6200300

10.1111/j.1478-3231.2009.01975.x

10.1080/08880010490273019

10.7326/0003-4819-148-7-200804010-00008

10.1111/j.1365-2893.2007.00902.x

10.1016/S0264-410X(99)00456-9

10.1016/j.puhe.2005.04.008

World Health Organization, 2004, Hepatitis B Vaccines. WHO position paper, Weekly Epidemiol Rec, 79, 254

10.1016/j.ajic.2005.12.018

Shaaban FA, 2007, Long‐term immunity to hepatitis B among a sample of fully vaccinated children in Cairo, Egypt, East Mediterr Health J, 13, 750

Memon AR, 2007, Hepatitis B vaccination status and knowledge, attitude, practices of health care workers (HCWs) regarding hepatitis B and C in a tertiary care setting of Karachi, Infect Dis J Pak, 16, 105

10.1186/1471-2334-7-120

Abbas Z, 2004, PSG Consensus statement on management of hepatitis B virus infection – 2003, J Pak Med Assoc, 54, 150

Prime Minister Program for Prevention and Control of Hepatitis in Pakistan (2005–10). Part III: Chapter 19:Health and Nutrition: p 188. Available at:http://www.pakistan.gov.pk/ministries/planninganddevelopment‐ministry/annualplan2007‐08.htm(accessed 14 November 2008).

10.1016/j.jhep.2008.10.001

Akarca US and Turkish Society for the Study of Liver.Chronic hepatitis B: a guideline to diagnosis approach management and follow‐up 2007. Available at:http://www.tasl.org.tr/UserFiles/File/HBV‐kilavuz‐13092007.pdf(accessed 8 November 2010).

10.1053/j.gastro.2007.08.079

10.1056/NEJMoa033364

Yuen MF, 2007, Long‐term lamivudine therapy reduces the risk of long‐term complications of chronic hepatitis B infection even in patients without advanced disease, Antivir Ther, 12, 1295, 10.1177/135965350701200816

10.1111/j.1365-2036.2008.03816.x

10.1053/j.gastro.2006.09.020

HadziyannisS SevastianosV RaptiI.Outcome of HBeAg‐negative chronic hepatitis B (CHB) 5 years after discontinuation of long term adefovir dipivoxil (ADV) treatment. Proc 44th Annual Meeting of the European Association for the Study of Liver Conference 2009. Copenhagen Denmark: Abstract 18.

10.1056/NEJMoa051287

10.1053/j.gastro.2007.08.025

10.1002/hep.22841

Shouval D, 2008, Three years of entecavir (ETV) retreatment of HBeAg‐ ETV patients who previously discontinued ETV treatment: results from study ETV 901, Hepatology, 48, 722A

10.1053/j.gastro.2008.10.026

10.1056/NEJMoa0802878

10.1136/gut.2005.065136