Journal of Translational Medicine
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Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy
Journal of Translational Medicine - Tập 17 - Trang 1-9 - 2019
A wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in regard to their therapeutic use in the setting of difficult-to-treat cutaneous ulcers is still poor. An 83-year-old woman suffering a critical limb ischemia a...... hiện toàn bộ
Inhibition of NOS1 promotes the interferon response of melanoma cells
Journal of Translational Medicine - Tập 20 - Trang 1-12 - 2022
NOS1 expression predicts poor prognosis in patients with melanoma. However, the molecular function of NOS1 in the type I IFN response and immune escape of melanoma is still unknown. The CRISPR/Cas9 system was used to generate NOS1-knockout melanoma cells and the biological characteristics of NOS1-knockout cells were evaluated by MTT assay, clonogenic assay, EdU assay, and flow cytometric assay. Th...... hiện toàn bộ
Comparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach
Journal of Translational Medicine - Tập 16 - Trang 1-13 - 2018
Dental caries is a major worldwide oral disease afflicting a large proportion of children. As an important host factor of caries susceptibility, saliva plays a significant role in the occurrence and development of caries. The aim of the present study was to characterize the healthy and cariogenic salivary proteome and determine the changes in salivary protein expression of children with varying de...... hiện toàn bộ
The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival
Journal of Translational Medicine - Tập 15 - Trang 1-13 - 2017
Biomarkers of early plaque progression are still elusive. Myeloid DAP12-associating lectin-1 (MDL-1), also called CLEC5A, is a C-type lectin receptor implicated in the progression of multiple acute and chronic inflammatory diseases. However, the relationship between its level and atherosclerosis is unknown. In this study, we aimed to investigate the correlation between macrophage MDL-1 expression ...... hiện toàn bộ
Granulocyte colony-stimulating factor affects the distribution and clonality of TRGV and TRDV repertoire of T cells and graft-versus-host diseaseAbstract Background The immune modulatory effect of granulocyte colony-stimulating factor (G-CSF) on T cells resulted in an unexpected low incidence of graft-versus-host disease (GVHD) in allogeneic peripheral blood stem cell transplantation (allo-PBSCT). Recent data indicated that gamma delta+ T cells might part...
Journal of Translational Medicine - Tập 9 Số 1 - 2011
Hypothetical membrane mechanisms in essential tremor
Journal of Translational Medicine - Tập 6 - Trang 1-11 - 2008
Essential tremor (ET) is the most common movement disorder and its pathophysiology is unknown. We hypothesize that increased membrane excitability in motor circuits has a key role in the pathogenesis of ET. Specifically, we propose that neural circuits controlling ballistic movements are inherently unstable due to their underlying reciprocal innervation. Such instability is enhanced by increased n...... hiện toàn bộ
Therapeutic mechanisms of mesenchymal stem cells in acute respiratory distress syndrome reveal potentials for Covid-19 treatment
Journal of Translational Medicine - Tập 19 - Trang 1-13 - 2021
The mortality rate of critically ill patients with acute respiratory distress syndrome (ARDS) is 30.9% to 46.1%. The emergence of the coronavirus disease 2019 (Covid-19) has become a global issue with raising dire concerns. Patients with severe Covid-19 may progress toward ARDS. Mesenchymal stem cells (MSCs) can be derived from bone marrow, umbilical cord, adipose tissue and so on. The easy access...... hiện toàn bộ
Human endometrial regenerative cells alleviate carbon tetrachloride-induced acute liver injury in mice
Journal of Translational Medicine - Tập 14 - Trang 1-15 - 2016
The endometrial regenerative cell (ERC) is a novel type of adult mesenchymal stem cell isolated from menstrual blood. Previous studies demonstrated that ERCs possess unique immunoregulatory properties in vitro and in vivo, as well as the ability to differentiate into functional hepatocyte-like cells. For these reasons, the present study was undertaken to explore the effects of ERCs on carbon tetra...... hiện toàn bộ
LncRNA NEAT1 facilitates glioma progression via stabilizing PGK1
Journal of Translational Medicine - Tập 20 - Trang 1-13 - 2022
Long noncoding RNA NEAT1 has been implicated in glioma progression. However, the effect of NEAT1 on glycolysis of glioma cell and the potential mechanism remain unclear. In vitro experiments, including CCK-8, colony formation, ECAR, and lactate detection assays were performed to evaluate the effect of NEAT1 on proliferation and glycolysis of glioma cell. RNA pulldown and RIP assays were performed ...... hiện toàn bộ
Magnetique: an interactive web application to explore transcriptome signatures of heart failure
Journal of Translational Medicine - Tập 20 - Trang 1-9 - 2022
Despite a recent increase in the number of RNA-seq datasets investigating heart failure (HF), accessibility and usability remain critical issues for medical researchers. We address the need for an intuitive and interactive web application to explore the transcriptional signatures of heart failure with this work. We reanalysed the Myocardial Applied Genomics Network RNA-seq dataset, one of the larg...... hiện toàn bộ
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