Journal of Translational Medicine

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SIX1 amplification modulates stemness and tumorigenesis in breast cancer
Journal of Translational Medicine - Tập 21 - Trang 1-20 - 2023
Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen, Shengrong Sun
Sine oculis homeobox homolog 1 (SIX1) is a transcription factor that has recently been identified as a crucial regulator of embryonic development and tumorigenesis. SIX1 is upregulated in different types of tumors, including breast cancer. However, the role and mechanism of SIX1 upregulation in breast cancer carcinogenesis remains uncertain. In this study, we utilized various databases such as UAL...... hiện toàn bộ
The effects of statins on dental and oral health: a review of preclinical and clinical studies
Journal of Translational Medicine - Tập 18 Số 1 - 2020
Shabnam Tahamtan, Farinaz Shirban, Mohammad Bagherniya, Thomas P. Johnston, Amirhossein Sahebkar
AbstractThe statin family of drugs are safe and effective therapeutic agents for the treatment of arteriosclerotic cardiovascular disease (CVD). Due to a wide range of health benefits in addition to their cholesterol lowering properties, statins have recently attracted significant attention as a new treatment strategy for several conditions, which are not directly ...... hiện toàn bộ
Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198
Journal of Translational Medicine - Tập 19 - Trang 1-14 - 2021
Jin-xiu Zhong, Yun-yuan Kong, Rong-guang Luo, Guo-jin Xia, Wen-xing He, Xue-zhong Chen, Wei-wei Tan, Qing-jie Chen, Yu-yin Huang, Yan-xing Guan
Circular RNAs (circRNAs) are pivotal regulators of various human cancers and circ-ERBB2 is abnormally expressed in breast cancer cells. However, the role and mechanism of circ-ERBB2 in HER2-positive breast cancer are still unknown. The circ-ERBB2 expressions in the tumor tissues of HER2-positive breast cancer patients were tested using quantitative real-time PCR. The circ-ERBB2 function was invest...... hiện toàn bộ
A feedback loop between GATA2-AS1 and GATA2 promotes colorectal cancer cell proliferation, invasion, epithelial-mesenchymal transition and stemness via recruiting DDX3X
Journal of Translational Medicine - Tập 20 - Trang 1-16 - 2022
Yuliang Pan, Yuxing Zhu, Jun Zhang, Long Jin, Peiguo Cao
Colorectal cancer (CRC) is a common malignant tumor with a high risk of metastasis. Long non-coding RNAs (lncRNAs) have been reported to be implicated in cancer progression via regulating its nearby gene. Herein, we investigated the function of GATA binding protein 2 (GATA2) and lncRNA GATA2 antisense RNA 1 (GATA2-AS1) in CRC and the mechanism underlying their interaction. Colony formation assay, ...... hiện toàn bộ
Asymmetric HIV-1 co-receptor use and replication in CD4+ T lymphocytes
Journal of Translational Medicine - Tập 9 Số S1 - 2011
Samanta A. Mariani, Elisa Vicenzi, Guido Poli
AbstractSusceptibility to infection by the human immunodeficiency virus type-1 (HIV-1), bothin vitroandin vivo,requires the interaction between its envelope (Env) glycoprotein gp120 Env and the primary receptor (R), CD4, and Co-R, either CCR5 or CXCR4, members of the chemokine receptor family. CCR5-dependent (R5...... hiện toàn bộ
Triglyceride to high-density lipoprotein cholesterol ratio is associated with regression to normoglycemia from prediabetes in adults: a 5-year cohort study in China
Journal of Translational Medicine - - 2023
Zhiqiang Huang, Yong Han, Haofei Hu, Changchun Cao, Dehong Liu, Zhibin Wang
The current body of evidence on the association between the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and the reversal of prediabetes to normoglycemia remains limited. The aim of this study is to investigate the association between TG/HDL-c and the reversion to normoglycemia in patients with prediabetes. This retrospective cohort study included 15,107 individuals wi...... hiện toàn bộ
Announcing the Tumor Immunology and Biological Cancer Therapy section (edited by iSBTc) of the Journal of Translational Medicine
Journal of Translational Medicine - - 2009
Pedro Romero, Bernard A. Fox
Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer
Journal of Translational Medicine -
Junhe Zhang, Yunxi Xiao, Jie Zhang, Yan Yang, Liao Zhang, Fanrong Liang
AbstractLiver cancer is a major malignant tumor, which seriously threatens human health and increases the economic burden on patients. At present, gene therapy has been comprehensively studied as an excellent therapeutic measure in liver cancer treatment. Oncolytic virus (OV) is a kind of virus that can specifically infect and kill tumor cells. After being modified...... hiện toàn bộ
Immunotherapy trials in Parkinson’s disease: challenges
Journal of Translational Medicine - Tập 21 - Trang 1-3 - 2023
Bin Xiao, Eng-King Tan
Forkhead box transcription factor 1 expression in gastric cancer: FOXM1 is a poor prognostic factor and mediates resistance to docetaxel
Journal of Translational Medicine - Tập 11 - Trang 1-13 - 2013
Xiaoxiao Li, Wensheng Qiu, Bin Liu, Ruyong Yao, Shihai Liu, Yasai Yao, Jun Liang
Forkhead box transcription factor 1 (FOXM1) has been reported to overexpress and correlate with pathogenesis in a variety of human malignancies. However, little research has been done to investigate its clinical significance in gastric cancer. We examined the expression of FOXM1 in 103 postoperational gastric cancer tissues and 5 gastric cell lines by immunohistochemistry and western blot analysis...... hiện toàn bộ
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