Journal of Translational Medicine
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SIX1 amplification modulates stemness and tumorigenesis in breast cancer
Journal of Translational Medicine - Tập 21 - Trang 1-20 - 2023
Sine oculis homeobox homolog 1 (SIX1) is a transcription factor that has
recently been identified as a crucial regulator of embryonic development and
tumorigenesis. SIX1 is upregulated in different types of tumors, including
breast cancer. However, the role and mechanism of SIX1 upregulation in breast
cancer carcinogenesis remains uncertain. In this study, we utilized various
databases such as UAL...
The effects of statins on dental and oral health: a review of preclinical and clinical studies
Journal of Translational Medicine - Tập 18 Số 1 - 2020
AbstractThe statin family of drugs are safe and effective therapeutic agents for
the treatment of arteriosclerotic cardiovascular disease (CVD). Due to a wide
range of health benefits in addition to their cholesterol lowering properties,
statins have recently attracted significant attention as a new treatment
strategy for several conditions, which are not directly related to normalizing a
lipid pr...
Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198
Journal of Translational Medicine - Tập 19 - Trang 1-14 - 2021
Circular RNAs (circRNAs) are pivotal regulators of various human cancers and
circ-ERBB2 is abnormally expressed in breast cancer cells. However, the role and
mechanism of circ-ERBB2 in HER2-positive breast cancer are still unknown. The
circ-ERBB2 expressions in the tumor tissues of HER2-positive breast cancer
patients were tested using quantitative real-time PCR. The circ-ERBB2 function
was invest...
A feedback loop between GATA2-AS1 and GATA2 promotes colorectal cancer cell proliferation, invasion, epithelial-mesenchymal transition and stemness via recruiting DDX3X
Journal of Translational Medicine - Tập 20 - Trang 1-16 - 2022
Colorectal cancer (CRC) is a common malignant tumor with a high risk of
metastasis. Long non-coding RNAs (lncRNAs) have been reported to be implicated
in cancer progression via regulating its nearby gene. Herein, we investigated
the function of GATA binding protein 2 (GATA2) and lncRNA GATA2 antisense RNA 1
(GATA2-AS1) in CRC and the mechanism underlying their interaction. Colony
formation assay, ...
Asymmetric HIV-1 co-receptor use and replication in CD4+ T lymphocytes
Journal of Translational Medicine - Tập 9 Số S1 - 2011
AbstractSusceptibility to infection by the human immunodeficiency virus type-1
(HIV-1), bothin vitroandin vivo,requires the interaction between its envelope
(Env) glycoprotein gp120 Env and the primary receptor (R), CD4, and Co-R, either
CCR5 or CXCR4, members of the chemokine receptor family. CCR5-dependent (R5)
viruses are responsible for both inter-individual transmission and for
sustaining the...
Triglyceride to high-density lipoprotein cholesterol ratio is associated with regression to normoglycemia from prediabetes in adults: a 5-year cohort study in China
Journal of Translational Medicine - - 2023
The current body of evidence on the association between the ratio of
triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and the
reversal of prediabetes to normoglycemia remains limited. The aim of this study
is to investigate the association between TG/HDL-c and the reversion to
normoglycemia in patients with prediabetes. This retrospective cohort study
included 15,107 individuals wi...
Announcing the Tumor Immunology and Biological Cancer Therapy section (edited by iSBTc) of the Journal of Translational Medicine
Journal of Translational Medicine - - 2009
Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer
Journal of Translational Medicine -
AbstractLiver cancer is a major malignant tumor, which seriously threatens human
health and increases the economic burden on patients. At present, gene therapy
has been comprehensively studied as an excellent therapeutic measure in liver
cancer treatment. Oncolytic virus (OV) is a kind of virus that can specifically
infect and kill tumor cells. After being modified by genetic engineering, the
spec...
Immunotherapy trials in Parkinson’s disease: challenges
Journal of Translational Medicine - Tập 21 - Trang 1-3 - 2023
Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors
Journal of Translational Medicine - - 2020
Abstract Background Circulating tumor DNA (ctDNA) offers a convenient way to
monitor tumor progression and treatment response. Because tumor mutational
profiles are highly variable from person to person, a fixed content panel may be
insufficient to track treatment response in all patients. Methods We design
ctDNA fingerprint panels specific to individual patients which are based on
whole exome seq...
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