Journal of Rheumatology

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Incidence and Clinical Course of COVID-19 in Patients with Connective Tissue Diseases: A Descriptive Observational Analysis
Journal of Rheumatology - Tập 47 Số 8 - Trang 1296-1296 - 2020
Ennio Giulio Favalli, Elena Agape, Roberto Caporali
Deregulated NLRP3 and NLRP1 Inflammasomes and Their Correlations with Disease Activity in Systemic Lupus Erythematosus
Journal of Rheumatology - Tập 41 Số 3 - Trang 444-452 - 2014
Qingrui Yang, Chengcheng Yu, Zhaowen Yang, Qing Wei, Kun Mu, Ying Zhang, Wei Zhao, Xiaofeng Wang, Wanwan Huai, Lihui Han
Objective.NOD-like receptor family, pyrin domain containing 3 and 1 (NLRP3 and NLRP1) inflammasomes are molecular platforms that sense the damage or danger signals of cells. We investigated whether NLRP3/NLRP1 inflammasomes are involved in the pathogenesis and progression of systemic lupus erythematosus (SLE).Methods.Expressions of inflammasome components at the mRNA and protein levels in the peri... hiện toàn bộ
Agreement Between the DAS28-CRP Assessed with 3 and 4 Variables in Patients with Rheumatoid Arthritis Treated with Biological Agents in the Daily Clinic
Journal of Rheumatology - Tập 40 Số 4 - Trang 379-385 - 2013
Ole Rintek Madsen
Objective.The Disease Activity Score-28-C-reactive Protein 4 [DAS28-CRP(4)] composite measure for rheumatoid arthritis (RA) is based on 4 variables: tender and swollen joint counts, CRP, and patient global assessment. DAS28-CRP(3) includes only 3 variables, because patient global assessment has been omitted. Thresholds for low and high disease activity are the same for the 2 scores. The objective ... hiện toàn bộ
Autosome-wide Copy Number Variation Association Analysis for Rheumatoid Arthritis Using the WTCCC High-density SNP Genotype Data
Journal of Rheumatology - Tập 38 Số 5 - Trang 797-801 - 2011
Mohammed Uddin, Mitch Sturge, Proton Rahman, Michael O. Woods
Objective.Rheumatoid arthritis (RA) is a complex autoimmune rheumatic disease that is strongly influenced by genetic factors. Numerous genes are convincingly associated with RA, including genes in tumor necrosis factor signaling (TNF) and the nuclear factor-κB pathway. To date, except for genes within the HLA region, no data exist regarding potential copy number variations (CNV) involving RA-assoc... hiện toàn bộ
Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus Erythematosus
Journal of Rheumatology - Tập 36 Số 8 - Trang 1631-1638 - 2009
Annachiara Cagnin, Tiina M. Järvinen, Sari Koskenmies, Marco Zucchelli, Christina Orsmark‐Pietras, Linda Berglind, Jaana Panelius, Taina Hasan, Heikki Julkunen, Mauro D’Amato, Ulpu Saarialho‐Kere, Juha Kere
Objective.Several candidate genes have been implicated in susceptibility for systemic lupus erythematosus (SLE), a complex autoimmune disease. The proposed genes include members of the type I interferon (IFN) pathway and genes involved in immunological defense functions. Our aim was to systematically replicate 6 such genes, TYK2, IRF5, CTLA4, PDCD1, FCGR2A, and NOD2.Methods.Single-nucleotide polym... hiện toàn bộ
Association of Polymorphisms in Interferon Regulatory Factor 5 Gene with Rheumatoid Arthritis: A Metaanalysis
Journal of Rheumatology - Tập 36 Số 4 - Trang 693-697 - 2009
Seung Woo Han, Won Ki Lee, Ki Tae Kwon, Byung Ki Lee, Eon Jeong Nam, GUN WOO KIM
Objective.We investigated potential associations between rheumatoid arthritis (RA) and interferon regulatory factor 5 (IRF5) polymorphisms in a metaanalysis.Methods.This metaanalysis included 5 case-control studies, which provided a total of 6582 RA cases and 5375 controls. Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) inIRF5(rs7... hiện toàn bộ
Patients with Rheumatoid Arthritis in Clinical Remission Manifest Persistent Joint Inflammation on Histology and Imaging Studies
Journal of Rheumatology - Tập 41 Số 11 - Trang 2153-2160 - 2014
Allen Anandarajah, Ralf Thiele, Ellen Giampoli, Johnny U. V. Monu, Gwysuk Seo, Changyong Feng, Christopher T. Ritchlin
Objective.The purpose of our study was to test the hypothesis that synovitis on magnetic resonance imaging (MRI) and ultrasound (US) observed in patients with rheumatoid arthritis (RA) who meet remission criteria reflects active inflammation on histopathology.Methods.We analyzed 15 synovial specimens obtained during surgical procedures from 14 patients with RA in clinical remission as defined by t... hiện toàn bộ
Subclinical Synovitis Assessed by Ultrasound Predicts Flare and Progressive Bone Erosion in Rheumatoid Arthritis Patients with Clinical Remission: A Systematic Review and Metaanalysis
Journal of Rheumatology - Tập 43 Số 11 - Trang 2010-2018 - 2016
Jingjing Han, Yan Geng, Xuerong Deng, Zhuoli Zhang
Objective.Subclinical synovitis can be detected by ultrasound in patients with rheumatoid arthritis (RA) who are in clinical remission. We aimed to confirm its predictive value for flare and progressive bone erosion.Methods.A systematic literature search was performed in Pubmed, Web of Science, Embase, and Cochrane Library on September 7, 2014. Baseline clinical and ultrasonographic characteristic... hiện toàn bộ
Effectiveness of Tumor Necrosis Factor Inhibitors in Combination with Various csDMARD in the Treatment of Rheumatoid Arthritis: Data from the DREAM Registry
Journal of Rheumatology - Tập 43 Số 10 - Trang 1787-1794 - 2016
S. Manders, Wietske Kievit, Tim Jansen, Jan Stolk, Henk Visser, A. Schilder, Harald E. Vonkeman, Eddy Adang, Mart A F J van de Laar, Piet L. C. M. van Riel
Objective.To analyze and compare the effectiveness and drug survival in patients with rheumatoid arthritis, as measured by 28-joint Disease Activity Score (DAS28) and Health Assessment Questionnaire–Disability Index (HAQ-DI), of tumor necrosis factor inhibitor (TNFi) monotherapy, TNFi + leflunomide (LEF), TNFi + sulfasalazine (SSZ), TNFi + other conventional synthetic disease-modifying antirheumat... hiện toàn bộ
Comparing Tapering Strategy to Standard Dosing Regimen of Tumor Necrosis Factor Inhibitors in Patients with Spondyloarthritis in Low Disease Activity
Journal of Rheumatology - Tập 42 Số 9 - Trang 1638-1646 - 2015
Chamaida Plasencia, E. Kneepkens, Gertjan Wolbink, C. Krieckaert, Samina A. Turk, Victoria Navarro‐Compán, M. l’Ami, Michael T. Nurmohamed, Irene van der Horst‐Bruinsma, Teresa Jurado‐Guerrero, Cristina Diego, Gema Bonilla, Alejandro Villalba, Diana Peiteado, Laura Nuño, Desirée van der Kleij, Theo Rispens, E. Martín‐Mola, Alejandro Balsa, Dora Pascual‐Salcedo
Objective.To compare clinical outcomes, incidence of flares, and administered drug reduction between patients with spondyloarthritis (SpA) under TNF inhibitor (TNFi) tapering strategy with patients receiving a standard regimen.Methods.In this retrospective study, 74 patients with SpA from Spain on tapering strategy (tapering group; TG) were compared with 43 patients from the Netherlands receiving ... hiện toàn bộ
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