Deregulated NLRP3 and NLRP1 Inflammasomes and Their Correlations with Disease Activity in Systemic Lupus ErythematosusJournal of Rheumatology - Tập 41 Số 3 - Trang 444-452 - 2014
Qingrui Yang, Chengcheng Yu, Zhaowen Yang, Qing Wei, Kun Mu, Ying Zhang, Wei Zhao, Xiaofeng Wang, Wanwan Huai, Lihui Han
Objective.NOD-like receptor family, pyrin domain containing 3 and 1 (NLRP3 and NLRP1) inflammasomes are molecular platforms that sense the damage or danger signals of cells. We investigated whether NLRP3/NLRP1 inflammasomes are involved in the pathogenesis and progression of systemic lupus erythematosus (SLE).Meth...... hiện toàn bộ
Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus ErythematosusJournal of Rheumatology - Tập 36 Số 8 - Trang 1631-1638 - 2009
Annachiara Cagnin, Tiina M. Järvinen, Sari Koskenmies, Marco Zucchelli, Christina Orsmark‐Pietras, Linda Berglind, Jaana Panelius, Taina Hasan, Heikki Julkunen, Mauro D’Amato, Ulpu Saarialho‐Kere, Juha Kere
Objective.Several candidate genes have been implicated in susceptibility for systemic lupus erythematosus (SLE), a complex autoimmune disease. The proposed genes include members of the type I interferon (IFN) pathway and genes involved in immunological defense functions. Our aim was to systematically replicate 6 such genes, TYK2, IRF5, CTLA4,...... hiện toàn bộ
Effectiveness of Tumor Necrosis Factor Inhibitors in Combination with Various csDMARD in the Treatment of Rheumatoid Arthritis: Data from the DREAM RegistryJournal of Rheumatology - Tập 43 Số 10 - Trang 1787-1794 - 2016
S. Manders, Wietske Kievit, Tim Jansen, Jan Stolk, Henk Visser, A. Schilder, Harald E. Vonkeman, Eddy Adang, Mart A F J van de Laar, Piet L. C. M. van Riel
Objective.To analyze and compare the effectiveness and drug survival in patients with rheumatoid arthritis, as measured by 28-joint Disease Activity Score (DAS28) and Health Assessment Questionnaire–Disability Index (HAQ-DI), of tumor necrosis factor inhibitor (TNFi) monotherapy, TNFi + leflunomide (LEF), TNFi + sulfasalazine (SSZ), TNFi + other conventio...... hiện toàn bộ
Comparing Tapering Strategy to Standard Dosing Regimen of Tumor Necrosis Factor Inhibitors in Patients with Spondyloarthritis in Low Disease ActivityJournal of Rheumatology - Tập 42 Số 9 - Trang 1638-1646 - 2015
Chamaida Plasencia, E. Kneepkens, Gertjan Wolbink, C. Krieckaert, Samina A. Turk, Victoria Navarro‐Compán, M. l’Ami, Michael T. Nurmohamed, Irene van der Horst‐Bruinsma, Teresa Jurado‐Guerrero, Cristina Diego, Gema Bonilla, Alejandro Villalba, Diana Peiteado, Laura Nuño, Desirée van der Kleij, Theo Rispens, E. Martín‐Mola, Alejandro Balsa, Dora Pascual‐Salcedo
Objective.To compare clinical outcomes, incidence of flares, and administered drug reduction between patients with spondyloarthritis (SpA) under TNF inhibitor (TNFi) tapering strategy with patients receiving a standard regimen.Methods.In this retrospective study, 74 patients with SpA from Spai...... hiện toàn bộ