Seung Woo Han1, Won Ki Lee2,3,4,5,6,7,8,9,10, Ki Tae Kwon2,3,4,5,6,7,8,9,10, Byung Ki Lee2,3,4,5,6,7,8,9,10, Eon Jeong Nam2,3,4,5,6,7,8,9,10, GUN WOO KIM2,3,4,5,6,7,8,9,10
1The Center of Rheumatology, Department of Internal Medicine, Daegu Fatima Hospital, and Department of Preventive Medicine, Kyungpook National University School of Medicine, 576-13, Sinam 4 dong, Donggu, Daegu, 701-010, Republic of Korea.
2Daegu Fatima Hospital; Department of Preventive Medicine, Kyungpook National University School of Medicine; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Daegu Fatima Hospital; Division of Rheumatology, Department of Internal Medicine,
3Department of Internal Medicine, Daegu Fatima Hospital, 576-13, Sinam 4 dong, Donggu, Daegu, 701-010, Republic of Korea.
4Department of Internal Medicine, Daegu Fatima Hospital; W.
5Department of Preventive Medicine, Kyungpook National University School of Medicine; B.
6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Daegu Fatima Hospital;
7Division of Rheumatology, Department of Internal Medicine, Kyungpook National University School of Medicine.
8From the Division of Rheumatology, Department of Internal Medicine,
9Kyungpook National University School of Medicine, Daegu, Republic of Korea
10The Center of Rheumatology,
Tóm tắt
Objective.We investigated potential associations between rheumatoid arthritis (RA) and interferon regulatory factor 5 (IRF5) polymorphisms in a metaanalysis.Methods.This metaanalysis included 5 case-control studies, which provided a total of 6582 RA cases and 5375 controls. Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) inIRF5(rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles.Results.Among 4 candidate SNP, rs729302, rs2004640, and rs2280714 were statistically significant; both allele C of rs729302 and allele G of rs2004640 within the promoter region ofIRF5were associated with a protective effect [random-effects (RE) OR 0.889, 95% confidence interval (CI) 0.803–0.977, p = 0.015 for rs729302; and RE OR 0.905, 95% CI 0.848–0.965, p = 0.002 for rs2004640]. Similar results were also obtained in T allele of rs2280714 in the 3’-untranslated region (RE OR 0.927, 95% CI 0.866–0.992, p = 0.029). There was no evidence of publication bias from funnel-plot asymmetry and Egger’s regression test.Conclusion.Our metaanalysis supported the evidence of the significant role ofIRF5polymorphisms in RA.
