Journal of Pharmaceutical Investigation
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3(2) Designing and optimization of aceclofenac transdermal films using response surface methodology: investigating the effect of hydrophilic and hydrophobic matrix on ex vivo and in vivo permeation characteristics
Journal of Pharmaceutical Investigation - Tập 47 - Trang 541-558 - 2016
3(2) factorial design and response surface methodology in the fabrication of matrix transdermal films of aceclofenac (ACL) was utilized in this study to investigate the effects of polymers (hydrophilic and hydrophobic) and penetration enhancer (PE) on ex vivo and in vivo drug performance. FTIR and DSC showed no interaction of drug with polymers. The physicochemical characterization showed uniformi...... hiện toàn bộ
Evaluation of nitroglycerin and cyclosporin A sorption to polyvinylchloride- and non-polyvinylchloride-based tubes in administration sets
Journal of Pharmaceutical Investigation - Tập 48 Số 6 - Trang 665-672 - 2018
Digestive enzyme supplementation in prescription drugs, over-the-counter drugs, and enzyme foods
Journal of Pharmaceutical Investigation - Tập 53 - Trang 343-355 - 2022
Digestive enzyme supplements are used in various fields, including prescription drugs, over-the-counter drugs, and enzyme foods, but few comprehensively organized data are available. In addition, the classification of products containing digestive enzymes differs by country, and except for the treatment of pancreatic insufficiency (PEI), clinical data are lacking. This review summarizes current kn...... hiện toàn bộ
Development of prediction model with machine learning in continuous twin screw granulation
Journal of Pharmaceutical Investigation - - 2023
This study aimed to use machine learning to predict the quality of a drug product prepared through continuous manufacturing. A design of experiment (DoE) was employed to identify the relationship between process parameters in continuous twin screw granulation and intermediate and drug product quality. Subsequently, unsupervised and supervised machine learning were applied to develop a dissolution ...... hiện toàn bộ
Simultaneous analysis of ibuprofen and pamabrom by HPLC
Journal of Pharmaceutical Investigation - Tập 45 - Trang 555-560 - 2015
A selective and simple HPLC method was developed for ibuprofen (IBF) and pamabrom (PAMB) from in bulk and drug product using the same conditions, which was operated on a reverse phase (C18 column) with water (60 %) and acetonitrile (40 %.) solutions at a flow rate of 1.0 mL/min. IBF was detected at 2.6 min and PAMB at 8.0 min, respectively at 254 nm. The correlation coefficient (R
...... hiện toàn bộ
High payload dexamethasone palmitate-loaded solid lipid nanoparticles for enhanced anti-inflammatory effects in acute skin inflammation model
Journal of Pharmaceutical Investigation - - 2024
Dexamethasone palmitate (DXPL) is a lipophilic derivative of dexamethasone (DXM) used to overcome the low drug-loading capacity and immediate release characteristics of DXM from nanoparticles. In this study, we investigated the potential of DXPL-loaded solid lipid nanoparticles (DXPL-SLNs) to increase drug encapsulation efficiency, prolong drug release, and alleviate skin inflammation. DXPL-SLNs w...... hiện toàn bộ
A pharmaceutical investigation into exosomes
Journal of Pharmaceutical Investigation - Tập 48 - Trang 617-626 - 2018
During the last 5 years, there has been a marked rise in publications regarding exosomes. Exosomes find potential applications as diagnostic biomarkers, therapeutics, drug delivery vehicles, and functional cosmetics and several exosome-based therapies are under clinical trials. Exosomes are nanosized vesicles that contain cell-derived lipid membranes, nucleic acids, and proteins, and are released ...... hiện toàn bộ
Microemulsion for nasal delivery of Asenapine maleate in treatment of schizophrenia: formulation considerations
Journal of Pharmaceutical Investigation - Tập 48 - Trang 301-312 - 2017
The objective of this study was to develop and evaluate the microemulsion (ME) and mucoadhesive microemulsion (MME) for intranasal delivery of Asenapine maleate (APM) for the treatment of schizophrenia. APM loaded ME (AME1 to AME5) and MME (AMME) were prepared by spontaneous microemulsification method and evaluated for drug content, globule size and polydispersity index, % transmittance, zeta pote...... hiện toàn bộ
Strategic design and clinical evaluation of a fixed-dose combination tablet comprising valsartan, amlodipine, rosuvastatin and ezetimibe for patients with hypertension and dyslipidemia
Journal of Pharmaceutical Investigation - - Trang 1-14 - 2023
The objective of this study was to design a fixed-dose combination (FDC) tablet with minimal interaction of valsartan, amlodipine, rosuvastatin and ezetimibe to improve medication compliance in patients with hypertension and dyslipidemia and to evaluate its feasibility for development through in vitro dissolution test and pharmacokinetic assessment in humans. The formulation was designed as a bila...... hiện toàn bộ
Effects of absorbent materials on a self-emulsifying drug delivery system for a poorly water soluble drug
Journal of Pharmaceutical Investigation - Tập 45 - Trang 529-539 - 2015
In order to compare the effects of a solid carrier on the formulation of a solid self-microemulsifying drug delivery system (s-SMEDDS), a liquid SMEDDS was prepared with simvastatin. The SMEDDS was optimized using polyoxyl 35 castor oil [Kolliphor® EL] as a surfactant (S), diethylene glycol monoethylether [Transcutol® P] as a co-surfactant (C), and prophyleneglycol monocaprylate [Capryol 90] as th...... hiện toàn bộ
Tổng số: 434
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