Journal of Pharmaceutical Investigation
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Characterization of crosslinked hard gelatin capsules for a structural assembly of elementary osmotic pump delivery system
Journal of Pharmaceutical Investigation - Tập 49 - Trang 655-665 - 2019
The objective of this study was to characterize the crosslinked hard gelatin capsules (HGCs) for use as a structural assembly of elementary osmotic pumps (EOP). HGCs were crosslinked in formaldehyde vapor for 6, 12, and 24 h. Weight loss after immersing in various mediums, water soluble protein fraction, loss on drying, and formaldehyde residue were investigated. Fourier transform infrared (FTIR) ......
In-vitro release and in-vivo performance of tolmetin from different topical gel formulations
Journal of Pharmaceutical Investigation - Tập 45 - Trang 311-317 - 2015
This study was designed to evaluate the suitability of Pluronic F-127, different grades of Carbopol and cellulosic polymers as gel bases containing tolmetin, a non-steroidal anti-inflammatory drug. In vitro release characteristics, effect of enhancers, viscosity and the mechanism of drug release for different gel bases was studied as well as the anti-inflammatory activity were evaluated. The resul......
A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch
Journal of Pharmaceutical Investigation - - Trang 1-19 - 2024
A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to obtain further information. Drug-in-adhesive patches were fab......
Indole-based derivatives effect on rats with polycystic ovary syndrome
Journal of Pharmaceutical Investigation - Tập 47 - Trang 439-444 - 2017
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, for which efficient therapies are needed. In this study, PCOS was induced in rats by intraperitoneal administration of testosterone propionate (0.2 mg/kg). Indole-based compounds 5-hydroxy indole-2-carboxylic acid, N-acetyl-tryptophan, Tryptamine, l-Tryptophan and Tryptophol were administered for 8 wee......
Regulatory and safe-use considerations related to stability after opening of nonsterile dosage forms
Journal of Pharmaceutical Investigation - Tập 52 - Trang 319-329 - 2022
The stability test after opening is conducted to establish an appropriate storage period during which the quality is maintained of multidose drug products that are opened and used repeatedly. While some of the regulatory agencies have provided guidelines for in-use stability study design, detailed guidelines covering various formulations are not provided. So, the guidelines are necessary to help t......
Potential of nanoparticulate carriers for improved drug delivery via skin
Journal of Pharmaceutical Investigation - Tập 49 Số 5 - Trang 485-517 - 2019
Comparison of adhesion and dissolution of fentanyl patches: Fentadur® and Durogesic DTrans®
Journal of Pharmaceutical Investigation - Tập 45 - Trang 475-480 - 2015
Fentanyl is a potent opioid used as an analgesic for pain therapy. Fentanyl patches have been developed using patch design technologies that use the transdermal route. The aim of this study was to compare the adhesion and dissolution properties of two fentanyl patches, Fentadur® (Pfizer Inc., USA) and Durogesic DTrans® (Janssen-Cilag, Inc., USA), which were designed as a reservoir and a matrix, r......
Delivery of biopharmaceuticals using combination of liposome and iontophoresis: a review
Journal of Pharmaceutical Investigation - Tập 45 - Trang 611-624 - 2015
Non-invasive route for the delivery of biopharmaceuticals is one of the interesting areas in drug delivery systems. Since stratum corneum is regarded as an effective physical barrier to permeation of high molecular weight biopharmaceuticals, several methods have been studied for overcoming this problem and enhancing their permeation. The one technique for better transdermal delivery is to use drug......
Recent advances in intra-articular drug delivery systems to extend drug retention in joint
Journal of Pharmaceutical Investigation - - 2019
Anti-neoplastic cytotoxicity by complementary simultaneous selective “targeted” delivery for pulmonary adenocarcinoma: fludarabine-(5′-phosphoramidate)-[anti-IGF-1R] in dual-combination with dexamethasone-(C21-phosphoramidate)-[anti-EGFR]
Journal of Pharmaceutical Investigation - Tập 49 - Trang 173-193 - 2018
Selective “targeted” delivery of chemotherapeutic agents represents a molecular strategy for achieving enhanced margins-of-safety and greater potency compared to conventional small-molecular weight chemotherapeutics. Greater margins-of-safety are possible because extensive un-intentional diffusion of therapeutics across intact cell membranes of normal healthy cells residing within tissues and orga......
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