Journal of Pharmaceutical Investigation
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Indole-based derivatives effect on rats with polycystic ovary syndrome
Journal of Pharmaceutical Investigation - Tập 47 - Trang 439-444 - 2017
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, for which efficient therapies are needed. In this study, PCOS was induced in rats by intraperitoneal administration of testosterone propionate (0.2 mg/kg). Indole-based compounds 5-hydroxy indole-2-carboxylic acid, N-acetyl-tryptophan, Tryptamine, l-Tryptophan and Tryptophol were administered for 8 wee......
Potential of nanoparticulate carriers for improved drug delivery via skin
Journal of Pharmaceutical Investigation - Tập 49 Số 5 - Trang 485-517 - 2019
Delivery of biopharmaceuticals using combination of liposome and iontophoresis: a review
Journal of Pharmaceutical Investigation - Tập 45 - Trang 611-624 - 2015
Non-invasive route for the delivery of biopharmaceuticals is one of the interesting areas in drug delivery systems. Since stratum corneum is regarded as an effective physical barrier to permeation of high molecular weight biopharmaceuticals, several methods have been studied for overcoming this problem and enhancing their permeation. The one technique for better transdermal delivery is to use drug......
Recent advances in intra-articular drug delivery systems to extend drug retention in joint
Journal of Pharmaceutical Investigation - - 2019
Ophthalmic dosage forms for drug delivery to posterior segment
Journal of Pharmaceutical Investigation - Tập 52 - Trang 161-173 - 2022
Degenerative ocular diseases such as macular retinopathy and retinal disorders significantly affect vision loss and the quality of life. The prevalence of these ophthalmic diseases is increasing due to surges in the elderly population and diabetes mellitus. Ophthalmic drug delivery systems for intraocular drug delivery have been studied and developed for decades. Due to multiple barriers in the ey......
Design of supersaturable formulation of telmisartan with pH modifier: in vitro study on dissolution and precipitation
Journal of Pharmaceutical Investigation - Tập 47 - Trang 163-171 - 2017
Telmisartan is a biopharmaceutics drug classification system class II drug having a low solubility at neutral pH region. The purpose of this study is to clarify the process of dissolution and precipitation of telmisartan in the gastrointestinal tract from its oral formulation containing meglumine, a pH modifier (alkalizer). Granules of telmisartan containing different amount of meglumine were prep......
In silico prediction of epitopes for Chikungunya viral strains
Journal of Pharmaceutical Investigation - Tập 45 - Trang 579-591 - 2015
Chikungunya is a viral infection transmitted by Aedes mosquitoes in humans. Currently there is no drug available for the treatment of this infection. In absence of a proven therapeutic, vaccines provide an alternative preventive measure for the spread of viral infection in risk prone population. The identification of epitopes is an important step in designing vaccines for viral infections. Traditi......
Sustained-release diclofenac potassium orally disintegrating tablet incorporating eudragit ERL/ERS: possibility of specific diclofenac-polymer interaction
Journal of Pharmaceutical Investigation - Tập 43 - Trang 171-183 - 2013
Sustained-release diclofenac potassium orally disintegrating tablet (ODT) formulations have been prepared and investigated. The ODTs were prepared by incorporating diclofenac potassium (DP), as a model for negatively ionizable drugs, in microcapsules that were prepared by the solvent evaporation method from a mixture of DP and different ratios of Eudragit RS and Eudragit RL, which are positively i......
Alginate-coated chitosan nanoparticles protect protein drugs from acid degradation in gastric media
Journal of Pharmaceutical Investigation - Tập 52 - Trang 465-476 - 2022
The aim of this study was to design and evaluate chitosan nanoparticles (CS NPs) coated with alginate which protect protein drugs from acid degradation.K The model protein drug used was bovine serum albumin (BSA). BSA-loaded CS NPs (BSA-CS NPs) were prepared using the ionic gelation method with sodium tripolyphosphate and the surface of the BSA-CS NPs were coated with sodium alginate (Alg). The op......
Recent trends of self-emulsifying drug delivery system for enhancing the oral bioavailability of poorly water-soluble drugs
Journal of Pharmaceutical Investigation - Tập 51 Số 4 - Trang 439-463 - 2021
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