Potential of nanoparticulate carriers for improved drug delivery via skin
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Aggarwal N, Goindi S (2012) Preparation and evaluation of antifungal efficacy of griseofulvin loaded deformable membrane vesicles in optimized guinea pig model of Microsporum canis—dermatophytosis. Int J Pharm 437:277–287
Alsarra IA, Bosela AA, Ahmed SM, Mahrous GM (2005) Proniosomes as a drug carrier for transdermal delivery of ketorolac. Eur J Pharm Biopharm 59:485–490
Arora R, Katiyar SS, Kushwah V, Jain S (2017) Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics in treatment of psoriasis: a comparative study. Expert Opin Drug Deliv 14:165–177
Balakrishnan P, Shanmugam S, Lee WS, Lee WM, Kim JO, Oh DH, Kim D-D, Kim JS, Yoo BK, Choi H-G (2009) Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery. Int J Pharm 377:1–8
Barry BW (1983) Dermatological formulations: percutaneous absorption. Marcel Dekker, New York
Barry BW (2001) Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 14:101–114
Barry BW (2002) Drug delivery routes in skin: a novel approach. Adv Drug Deliv Rev 54(Supplement):S31–S40
Boinpally RR, Zhou S-L, Poondru S, Devraj G, Jasti BR (2003) Lecithin vesicles for topical delivery of diclofenac. Eur J Pharm Biopharm 56:389–392
Bouwstra JA, Ponec M (2006) The skin barrier in healthy and diseased state. Biochim Biophys Acta 1758:2080–2095
Cevc G (2012) Rational design of new product candidates: the next generation of highly deformable bilayer vesicles for noninvasive, targeted therapy. J Control Release 160:135–146
Cevc G, Blume G (1992) Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim Biophys Acta 1104:226–232
Cevc G, Blume G (2001) New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, transfersomes. Biochim Biophys Acta 1514:191–205
Cevc G, Blume G (2003) Biological activity and characteristics of triamcinolone-acetonide formulated with the self-regulating drug carriers, transfersomes®. Biochim Biophys Acta 1614:156–164
Cevc G, Vierl U (2010) Nanotechnology and the transdermal route: A state of the art review and critical appraisal. J Control Release 141:277–299
Cevc G, Blume G, Schätzlein A, Gebauer D, Paul A (1996) The skin: a pathway for systemic treatment with patches and lipid-based agent carriers. Adv Drug Deliv Rev 18:349–378
Cevc G, Schätzlein A, Richardsen H (2002) Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurements. Biochim Biophys Acta 1564:21–30
Chaudhary H, Kohli K, Kumar V (2013) Nano-transfersomes as a novel carrier for transdermal delivery. Int J Pharm 454:367–380
Choi W-S, Cho H-I, Lee H-Y, Lee S-H, Choi Y-W (2010) Enhanced occlusiveness of nanostructured lipid carrier (NLC)-based carbogel as a skin moisturizing vehicle. J Pharm Investig 40:373–378
Chourasia MK, Kang L, Chan SY (2011) Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Results Pharm Sci 1:60–67
Contri RV, Fiel LA, Pohlmann AR, Guterres SS, Beck RCR (2011) Transport of substances and nanoparticles across the skin and in vitro models to evaluate skin permeation and/or penetration. In: Beck R, Guterres S, Pohlmann A (eds) Nanocosmetics and nanomedicines. Springer, Berlin, pp 3–35
Dayan N, Touitou E (2000) Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes. Biomaterials 21:1879–1885
Din FU, Aman W, Ullah I, Qureshi OS, Mustapha O, Shafique S, Zeb A (2017) Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomed 12:7291–7309
Dubey V, Mishra D, Asthana A, Jain NK (2006) Transdermal delivery of a pineal hormone: melatonin via elastic liposomes. Biomaterials 27:3491–3496
Dubey V, Mishra D, Dutta T, Nahar M, Saraf DK, Jain NK (2007a) Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. J Control Release 123:148–154
Dubey V, Mishra D, Jain NK (2007b) Melatonin loaded ethanolic liposomes: physicochemical characterization and enhanced transdermal delivery. Eur J Pharm Biopharm 67:398–405
El Maghraby GMM, Williams AC, Barry BW (1999) Skin delivery of oestradiol from deformable and traditional liposomes: mechanistic studies. J Pharm Pharmacol 51:1123–1134
El Maghraby GMM, Williams AC, Barry BW (2001) Skin hydration and possible shunt route penetration in controlled estradiol delivery from ultradeformable and standard liposomes. J Pharm Pharmacol 53:1311–1322
El Maghraby GMM, Williams AC, Barry BW (2006) Can drug-bearing liposomes penetrate intact skin? J Pharm Pharmacol 58:415–429
El Maghraby GM, Barry BW, Williams AC (2008) Liposomes and skin: from drug delivery to model membranes. Eur J Pharm Sci 34:203–222
Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM (2006) Deformable liposomes and ethosomes: mechanism of enhanced skin delivery. Int J Pharm 322:60–66
Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM (2007) Lipid vesicles for skin delivery of drugs: reviewing three decades of research. Int J Pharm 332:1–16
Fang J-Y, Hong C-T, Chiu W-T, Wang Y-Y (2001) Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm 219:61–72
Ferreira LS, Ramaldes GA, Nunan EA, Ferreira LA (2004) In vitro skin permeation and retention of paromomycin from liposomes for topical treatment of the cutaneous leishmaniasis. Drug Dev Ind Pharm 30:289–296
Gillet A, Grammenos A, Compère P, Evrard B, Piel G (2009) Development of a new topical system: drug-in-cyclodextrin-in-deformable liposome. Int J Pharm 380:174–180
Gillet A, Lecomte F, Hubert P, Ducat E, Evrard B, Piel G (2011) Skin penetration behaviour of liposomes as a function of their composition. Eur J Pharm Biopharm 79:43–53
Godin B, Touitou E (2003) Ethosomes: new prospects in transdermal delivery. Crit Rev Ther Drug Carrier Syst 20:63–102
Guo J, Ping Q, Sun G, Jiao C (2000) Lecithin vesicular carriers for transdermal delivery of cyclosporin A. Int J Pharm 194:201–207
Hamishehkar H, Rahimpour Y, Kouhsoltani M (2013) Niosomes as a propitious carrier for topical drug delivery. Expert Opin Drug Deliv 10:261–272
Han F, Li S, Yin R, Shi X, Jia Q (2008) Investigation of nanostructured lipid carriers for transdermal delivery of flurbiprofen. Drug Dev Ind Pharm 34:453–458
Han S, Kwon S, Jeong Y, Yu E, Park S (2014) Physical characterization and in vitro skin permeation of solid lipid nanoparticles for transdermal delivery of quercetin. Int J Cosmet Sci 36:588–597
Handjani-Vila R, Ribier A, Rondot B, Vanlerberghie G (1979) Dispersions of lamellar phases of non-ionic lipids in cosmetic products. Int J Cosmet Sci 1:303–314
Harris RA, Burnett R, McQuilkin S, McClard A, Simon FR (1987) Effects of ethanol on membrane order: fluorescence studies. Ann N Y Acad Sci 492:125–135
Honeywell-Nguyen PL, Bouwstra JA (2005) Vesicles as a tool for transdermal and dermal delivery. Drug Discov Today Technol 2:67–74
Jain S, Tiwary AK, Sapra B, Jain NK (2007) Formulation and evaluation of ethosomes for transdermal delivery of lamivudine. AAPS PharmSciTech 8:E111
Javadzadeh Y, Shokri J, Hallaj-Nezhadi S, Hamishehkar H, Nokhodchi A (2010) Enhancement of percutaneous absorption of finasteride by cosolvents, cosurfactant and surfactants. Pharm Dev Technol 15:619–625
Jenning V, Schäfer-Korting M, Gohla S (2000) Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties. J Control Release 66:115–126
Johnson ME, Blankschtein D, Langer R (1997) Evaluation of solute permeation through the stratum corneum: lateral bilayer diffusion as the primary transport mechanism. J Pharm Sci 86:1162–1172
Junyaprasert VB, Singhsa P, Suksiriworapong J, Chantasart D (2012) Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid. Int J Pharm 423:303–311
Kanitakis J (2002) Anatomy, histology and immunohistochemistry of normal human skin. Eur J Dermatol 12:390–399 (quiz 400–391)
Kawadkar J, Pathak A, Kishore R, Chauhan MK (2013) Formulation, characterization and in vitro–in vivo evaluation of flurbiprofen-loaded nanostructured lipid carriers for transdermal delivery. Drug Dev Ind Pharm 39:569–578
Kenneth AW, Michael SR (2002) The structure and function of skin. In: Kenneth AW (Ed.) Dermatological and transdermal formulations. CRC Press, Boca Raton, pp 1–39
Khalil RM, Abd-Elbary A, Kassem MA, Ghorab MM, Basha M (2014) Nanostructured lipid carriers (NLCs) versus solid lipid nanoparticles (SLNs) for topical delivery of meloxicam. Pharm Dev Technol 19:304–314
Khallaf RA, Salem HF, Abdelbary A (2016) 5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment. Drug Deliv 23:3452–3460
Khan NR, Harun MS, Nawaz A, Harjoh N, Wong TW (2015) Nanocarriers and their actions to improve skin permeability and transdermal drug delivery. Curr Pharm Des 21:2848–2866
Kitagawa S, Kasamaki M (2006) Enhanced delivery of retinoic acid to skin by cationic liposomes. Chem Pharm Bull 54:242–244
Kumar GP, Rajeshwarrao P (2011) Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta Pharm Sin B 1:208–219
Kurakula M, Ahmed OA, Fahmy UA, Ahmed TA (2016) Solid lipid nanoparticles for transdermal delivery of avanafil: optimization, formulation, in-vitro and ex-vivo studies. J Liposome Res 26:288–296
Liu D-Z, Chen W-Y, Tasi L-M, Yang S-P (2000) Microcalorimetric and shear studies on the effects of cholesterol on the physical stability of lipid vesicles. Colloids Surf A Physicochem Eng Asp 172:57–67
Liu H, Pan W-S, Tang R, Luo S-D (2004) Topical delivery of different acyclovir palmitate liposome formulations through rat skin in vitro. Pharmazie 59:203–206
Liu J, Hu W, Chen H, Ni Q, Xu H, Yang X (2007) Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm 328:191–195
Lopez-Pinto J, Gonzalez-Rodriguez M, Rabasco A (2005) Effect of cholesterol and ethanol on dermal delivery from DPPC liposomes. Int J Pharm 298:1–12
Maia CS, Mehnert W, Schäfer-Korting M (2000) Solid lipid nanoparticles as drug carriers for topical glucocorticoids. Int J Pharm 196:165–167
Mali N, Darandale S, Vavia P (2013) Niosomes as a vesicular carrier for topical administration of minoxidil: formulation and in vitro assessment. Drug Deliv Transl Res 3:587–592
Marianecci C, Di Marzio L, Rinaldi F, Celia C, Paolino D, Alhaique F, Esposito S, Carafa M (2014) Niosomes from 80 s to present: the state of the art. Adv Colloid Interface Sci 205:187–206
Marto J, Vitor C, Guerreiro A, Severino C, Eleuterio C, Ascenso A, Simoes S (2016) Ethosomes for enhanced skin delivery of griseofulvin. Colloids Surf B Biointerfaces 146:616–623
Mbah CC, Builders PF, Attama AA (2014) Nanovesicular carriers as alternative drug delivery systems: ethosomes in focus. Expert Opin Drug Deliv 11:45–59
Mehnert W, Mäder K (2012) Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 64:83–101
Mei Z, Chen H, Weng T, Yang Y, Yang X (2003) Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm 56:189–196
Menon GK (2002) New insights into skin structure: scratching the surface. Adv Drug Deliv Rev 54(Supplement):S3–S17
Mezei M, Gulasekharam V (1980) Liposomes-a selective drug delivery system for the topical route of administration. Lotion dosage form. Life Sci 26:1473–1477
Mishra D, Garg M, Dubey V, Jain S, Jain N (2007) Elastic liposomes mediated transdermal delivery of an anti-hypertensive agent: propranolol hydrochloride. J Pharm Sci 96:145–155
Moghassemi S, Hadjizadeh A (2014) Nano-niosomes as nanoscale drug delivery systems: an illustrated review. J Control Release 185:22–36
Montenegro L, Sinico C, Castangia I, Carbone C, Puglisi G (2012) Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation. Int J Pharm 434:169–174
Moser K, Kriwet K, Naik A, Kalia YN, Guy RH (2001) Passive skin penetration enhancement and its quantification in vitro. Eur J Pharm Biopharm 52:103–112
Muller RH, Mehnert W, Lucks JS, Schwarz C, Zur Muhlen A, Weyhers H, Freitas C, Ruhl D (1995) Solid lipid nanoparticles (SLN)—an alternative colloidal carrier system for controlled drug delivery. Eur J Pharm Biopharm 41:62–69
Müller RH, Mäder K, Gohla S (2000) Solid lipid nanoparticles (SLN) for controlled drug delivery—a review of the state of the art. Eur J Pharm Biopharm 50:161–177
Müller RH, Radtke M, Wissing SA (2002a) Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 242:121–128
Müller RH, Radtke M, Wissing SA (2002b) Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 54(Supplement):S131–S155
Muzzalupo R, Tavano L (2015) Niosomal drug delivery for transdermal targeting: recent advances. Res Rep Transderm Drug Deliv 4:23–33
Nasr M, Mansour S, Mortada ND, Elshamy A (2008) Vesicular aceclofenac systems: a comparative study between liposomes and niosomes. J Microencapsul 25:499–512
Neubert RHH (2011) Potentials of new nanocarriers for dermal and transdermal drug delivery. Eur J Pharm Biopharm 77:1–2
Oh YK, Kim MY, Shin JY, Kim TW, Yun MO, Yang SJ, Choi SS, Jung WW, Kim J, Choi HG (2006) Skin permeation of retinol in Tween 20-based deformable liposomes: in-vitro evaluation in human skin and keratinocyte models. J Pharm Pharmacol 58:161–166
Padamwar MN, Pokharkar VB (2006) Development of vitamin loaded topical liposomal formulation using factorial design approach: drug deposition and stability. Int J Pharm 320:37–44
Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M (2005) Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Control Release 106:99–110
Paolino D, Cosco D, Muzzalupo R, Trapasso E, Picci N, Fresta M (2008) Innovative bola-surfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer. Int J Pharm 353:233–242
Paolino D, Celia C, Trapasso E, Cilurzo F, Fresta M (2012) Paclitaxel-loaded ethosomes®: potential treatment of squamous cell carcinoma, a malignant transformation of actinic keratoses. Eur J Pharm Biopharm 81:102–112
Park SN, Jo NR, Jeon SH (2014a) Chitosan-coated liposomes for enhanced skin permeation of resveratrol. J Ind Eng Chem 20:1481–1485
Park SN, Lee HJ, Gu HA (2014b) Enhanced skin delivery and characterization of rutin-loaded ethosomes. Korean J Chem Eng 31:485–489
Patel V, Misra A, Marfatia Y (2001) Preparation and comparative clinical evaluation of liposomal gel of benzoyl peroxide for acne. Drug Dev Ind Pharm 27:863–870
Pegoraro C, MacNeil S, Battaglia G (2012) Transdermal drug delivery: from micro to nano. Nanoscale 4:1881–1894
Perez AP, Altube MJ, Schilrreff P, Apezteguia G, Celes FS, Zacchino S, de Oliveira CI, Romero EL, Morilla MJ (2016) Topical amphotericin B in ultradeformable liposomes: formulation, skin penetration study, antifungal and antileishmanial activity in vitro. Colloids Surf B Biointerfaces 139:190–198
Perez-Cullell N, Coderch L, de la Maza A, Parra JL, Estelrich J (2000) Influence of the fluidity of liposome compositions on percutaneous absorption. Drug Deliv 7:7–13
Pierre MBR, Tedesco AC, Marchetti JM, Bentley MVLB (2001) Stratum corneum lipids liposomes for the topical delivery of 5-aminolevulinic acid in photodynamic therapy of skin cancer: preparation and in vitro permeation study. BMC Dermatol 1:5–5
Prausnitz MR, Mitragotri S, Langer R (2004) Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 3:115–124
Puglia C, Trombetta D, Venuti V, Saija A, Bonina F (2004) Evaluation of in-vivo topical anti-inflammatory activity of indometacin from liposomal vesicles. J Pharm Pharmacol 56:1225–1232
Qureshi OS, Kim HS, Zeb A, Choi JS, Kim HS, Kwon JE, Kim MS, Kang JH, Ryou C, Park JS, Kim JK (2017) Sustained release docetaxel-incorporated lipid nanoparticles with improved pharmacokinetics for oral and parenteral administration. J Microencapsul 34:250–261
Ramon E, Alonso C, Coderch L, de la Maza A, Lopez O, Parra JL, Notario J (2005) Liposomes as alternative vehicles for sun filter formulations. Drug Deliv 12:83–88
Romero EL, Morilla MJ (2013) Highly deformable and highly fluid vesicles as potential drug delivery systems: theoretical and practical considerations. Int J Nanomedi 8:3171–3186
Rosen MR (2005) Delivery system handbook for personal care and cosmetic products: technology, applications and formulation, 1st ed. William Andrew, Norwich
Scheuplein RJ (1965) Mechanism of percutaneous absorption. 1. Routes of penetration and the influence of solubility. J Investig Dermatol 45:334–346
Scheuplein RJ (1976) Permeability of the skin: a review of major concepts and some new developments. J Investig Dermatol 67:672–676
Shuwaili AHA, Rasool BKA, Abdulrasool AA (2016) Optimization of elastic transfersomes formulations for transdermal delivery of pentoxifylline. Eur J Pharm Biopharm 102:101–114
Sinico C, Manconi M, Peppi M, Lai F, Valenti D, Fadda AM (2005) Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle–skin interaction. J Control Release 103:123–136
Solanki AB, Parikh JR, Parikh RH, Patel MR (2010) Evaluation of different compositions of niosomes to optimize aceclofenac transdermal delivery. Asian J Pharm Sci 5:87–95
Subongkot T, Ngawhirunpat T (2015) Effect of liposomal fluidity on skin permeation of sodium fluorescein entrapped in liposomes. Int J Nanomed 10:4581–4592
Tavano L, Alfano P, Muzzalupo R, de Cindio B (2011) Niosomes vs microemulsions: new carriers for topical delivery of capsaicin. Colloids Surf B Biointerfaces 87:333–339
Tavano L, Muzzalupo R, Picci N, de Cindio B (2014) Co-encapsulation of lipophilic antioxidants into niosomal carriers: percutaneous permeation studies for cosmeceutical applications. Colloids Surf B Biointerfaces 114:144–149
Torchilin VP (2005) Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 4:145–160
Touitou E (1996) Compositions for applying active substances to or through the skin. US patent 5,540,934
Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M (2000a) Ethosomes—novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 65:403–418
Touitou E, Godin B, Weiss C (2000b) Enhanced delivery of drugs into and across the skin by ethosomal carriers. Drug Dev Res 50:406–415
Touitou E, Godin B, Dayan N, Weiss C, Piliponsky A, Levi-Schaffer F (2001) Intracellular delivery mediated by an ethosomal carrier. Biomaterials 22:3053–3059
Trommer H, Neubert RH (2006) Overcoming the stratum corneum: the modulation of skin penetration. A review. Skin Pharmacol Physiol 19:106–121
Trotta M, Peira E, Carlotti ME, Gallarate M (2004) Deformable liposomes for dermal administration of methotrexate. Int J Pharm 270:119–125
Tupal A, Sabzichi M, Ramezani F, Kouhsoltani M, Hamishehkar H (2016) Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer. J Microencapsul 33:372–380
Uchechi O, Ogbonna JD, Attama AA (2014) Nanoparticles for dermal and transdermal drug delivery. In: Sezer AD (Ed.) Nanotechnology and nanomaterials: application of nanotechnology in drug delivery. InTech, Rijeka, pp 193–235
Uchegbu IF, Vyas SP (1998) Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int J Pharm 172:33–70
Uner M, Yener G (2007) Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. Int J Nanomed 2:289–300
Utreja P, Jain S, Tiwary A (2011) Localized delivery of paclitaxel using elastic liposomes: formulation development and evaluation. Drug Deliv 18:367–376
Van der Merwe D, Riviere JE (2005) Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane. Toxicol In Vitro 19:69–77
Verma DD, Verma S, Blume G, Fahr A (2003) Particle size of liposomes influences dermal delivery of substances into skin. Int J Pharm 258:141–151
Wissing SA, Müller RH (2003) Cosmetic applications for solid lipid nanoparticles (SLN). Int J Pharm 254:65–68
Wissing S, Kayser O, Müller R (2004) Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 56:1257–1272
Zeb A, Qureshi OS, Kim H-S, Cha J-H, Kim H-S, Kim J-K (2016) Improved skin permeation of methotrexate via nanosized ultradeformable liposomes. Int J Nanomed 11:3813
Zeb A, Qureshi OS, Kim HS, Kim MS, Kang JH, Park JS, Kim JK (2017a) High payload itraconazole-incorporated lipid nanoparticles with modulated release property for oral and parenteral administration. J Pharm Pharmacol 69:955–966
Zeb A, Qureshi OS, Yu C-H, Akram M, Kim H-S, Kim M-S, Kang J-H, Majid A, Chang S-Y, Bae O-N (2017b) Enhanced anti-rheumatic activity of methotrexate-entrapped ultradeformable liposomal gel in adjuvant-induced arthritis rat model. Int J Pharm 525:92–100
Zhang Y-T, Shen L-N, Zhao J-H, Feng N-P (2014) Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis. Int J Nanomed 9:669–678
Zhang Y, Zhang K, Wu Z, Guo T, Ye B, Lu M, Zhao J, Zhu C, Feng N (2015) Evaluation of transdermal salidroside delivery using niosomes via in vitro cellular uptake. Int J Pharm 478:138–146