Journal of Neuroscience

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Interaction of Genetic and Environmental Factors in aDrosophilaParkinsonism Model
Journal of Neuroscience - Tập 27 Số 10 - Trang 2457-2467 - 2007
Anathbandhu Chaudhuri, Kevin M. Bowling, Christopher D. Funderburk, Hakeem O. Lawal, Arati A. Inamdar, Zhe Wang, Janis M. O’Donnell
Catastrophic loss of dopaminergic neurons is a hallmark of Parkinson's disease. Despite the recent identification of genes associated with familial parkinsonism, the etiology of most Parkinson's disease cases is not understood. Environmental toxins, such as the herbicide paraquat, appear to be risk factors, and it has been proposed that susceptibility is influenced by genetic background. T...... hiện toàn bộ
Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number
Journal of Neuroscience - Tập 19 Số 14 - Trang 5919-5931 - 1999
A M LeMaster, Robin F. Krimm, Brian M. Davis, Teresa Noel, M E Forbes, James E. Johnson, Kathryn M. Albers
Target-derived neurotrophin growth factors have significant effects on the development and maintenance of the mammalian somatosensory system. Studies of transgenic mice that overexpress neurotrophins NGF and neurotrophin 3 (NT-3) at high levels in skin have shown increased sensory neuron number and enhanced innervation of specific sensory ending types. The effects of two other members of t...... hiện toàn bộ
Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
Journal of Neuroscience - Tập 21 Số 8 - Trang 2678-2686 - 2001
Jaime Garcı́a-Añoveros, Tarek A. Samad, Ljiljana Žuvela-Jelaska, Clifford J. Woolf, David P. Corey
Mammalian brain sodium channel (BNaC, also known as BNC/ASIC) proteins form acid-sensitive and amiloride-blockable sodium channels that are related to putative mechanosensory channels. Certain BNaC isoforms are expressed exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion channels mediating tissue acidosis-induced pain. With antibody labeling, we find that the B...... hiện toàn bộ
Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct
Journal of Neuroscience - Tập 19 Số 15 - Trang 6497-6505 - 1999
Cheryl L. Stucky, Gary R. Lewin
Small-diameter sensory neurons that are primarily nociceptors can be divided neurochemically into two populations: isolectin B4(IB4)-positive nonpeptidergic neurons, and IB4-negative peptidergic neurons. It has been shown that IB4-positive neurons depend on glial-derived neurotrophic factor (GDNF), whereas ...... hiện toàn bộ
Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro
Journal of Neuroscience - Tập 12 Số 1 - Trang 86-95 - 1992
Steen Kh, Peter W. Reeh, Fernand Anton, H. O. Handwerker
In ischemic and in inflamed tissues, pH levels down to 5.4 have been measured, and this local acidosis may contribute to pain and hyperalgesia in disease states. To evaluate the role of acid pH in nociception, we have studied identified primary afferents in a rat skin- saphenous nerve preparation in vitro where the receptive fields can be superfused at the highly permeable corium side with...... hiện toàn bộ
Coincident Activation of NMDA and Dopamine D1Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning
Journal of Neuroscience - Tập 20 Số 20 - Trang 7737-7742 - 2000
Stephanie L. Smith‐Roe, Ann E. Kelley
The nucleus accumbens, a brain structure ideally situated to act as an interface between corticolimbic information-processing regions and motor output systems, is well known to subserve behaviors governed by natural reinforcers. In the accumbens core, glutamatergic input from its corticolimbic afferents and dopaminergic input from the ventral tegmental area converge onto common dendrites o...... hiện toàn bộ
Polymorphisms in the Taste Receptor Gene (Tas1r3) Region Are Associated with Saccharin Preference in 30 Mouse Strains
Journal of Neuroscience - Tập 24 Số 4 - Trang 938-946 - 2004
Danielle R. Reed, S. Li, X. Li, Liquan Huang, Michael G. Tordoff, R. Starling-Roney, Kazumi Taniguchi, David B. West, J D Ohmen, Gary K. Beauchamp, Alexander A. Bachmanov
The results of recent studies suggest that the mouseSac(saccharin preference) locus is identical to theTas1r3(taste receptor) gene. The goal of this study was to identifyTas1r3sequence variants associated with saccharin preference in a large number of inbred mouse strains. Initially, we sequenced ∼6.7 kb of th...... hiện toàn bộ
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
Journal of Neuroscience - Tập 22 Số 3 - Trang 1063-1071 - 2002
Anne E. Baldwin, Ken Sadeghian, Ann E. Kelley
Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine
Journal of Neuroscience - Tập 2 Số 9 - Trang 1230-1241 - 1982
RR Goodman, SH Synder
Adenosine (A1) receptor binding sites have been localized in rat brain by an in vitro light microscopic autoradiographic method. The binding of [3H]N6-cyclohexyladenosine to slide-mounted rat brain tissue sections has the characteristics of A1 receptors. It is saturable with high affinity and has appropriate pharmacology and stereospecificity. The highest densities of adenosine receptors o...... hiện toàn bộ
High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system
Journal of Neuroscience - Tập 14 Số 5 - Trang 3059-3071 - 1994
Ratan V. Bhat, Jay M. Baraban, RC Johnson, Betty Eipper, Richard E. Mains
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene that is mutated in human familial adenomatous polyposis, an autosomal dominant condition with predisposition to colorectal carcinoma and brain tumors. Although tumor suppressor genes appear to play a general role in regulating cellular proliferation, the normal biological function of the APC gene product is unknown. In th...... hiện toàn bộ
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