Journal of Neuroscience
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Interaction of Genetic and Environmental Factors in aDrosophilaParkinsonism Model
Journal of Neuroscience - Tập 27 Số 10 - Trang 2457-2467 - 2007
Catastrophic loss of dopaminergic neurons is a hallmark of Parkinson's disease.
Despite the recent identification of genes associated with familial
parkinsonism, the etiology of most Parkinson's disease cases is not understood.
Environmental toxins, such as the herbicide paraquat, appear to be risk factors,
and it has been proposed that susceptibility is influenced by genetic
background. The genet...
Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number
Journal of Neuroscience - Tập 19 Số 14 - Trang 5919-5931 - 1999
Target-derived neurotrophin growth factors have significant effects on the
development and maintenance of the mammalian somatosensory system. Studies of
transgenic mice that overexpress neurotrophins NGF and neurotrophin 3 (NT-3) at
high levels in skin have shown increased sensory neuron number and enhanced
innervation of specific sensory ending types. The effects of two other members
of this fami...
Isolectin B4-Positive and -Negative Nociceptors Are Functionally Distinct
Journal of Neuroscience - Tập 19 Số 15 - Trang 6497-6505 - 1999
Small-diameter sensory neurons that are primarily nociceptors can be divided
neurochemically into two populations: isolectin B4(IB4)-positive nonpeptidergic
neurons, and IB4-negative peptidergic neurons. It has been shown that
IB4-positive neurons depend on glial-derived neurotrophic factor (GDNF), whereas
IB4-negative neurons depend on NGF for survival during postnatal development
(Molliver et al...
Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
Journal of Neuroscience - Tập 21 Số 8 - Trang 2678-2686 - 2001
Mammalian brain sodium channel (BNaC, also known as BNC/ASIC) proteins form
acid-sensitive and amiloride-blockable sodium channels that are related to
putative mechanosensory channels. Certain BNaC isoforms are expressed
exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion
channels mediating tissue acidosis-induced pain. With antibody labeling, we find
that the BNaC1α is...
Coincident Activation of NMDA and Dopamine D1Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning
Journal of Neuroscience - Tập 20 Số 20 - Trang 7737-7742 - 2000
The nucleus accumbens, a brain structure ideally situated to act as an interface
between corticolimbic information-processing regions and motor output systems,
is well known to subserve behaviors governed by natural reinforcers. In the
accumbens core, glutamatergic input from its corticolimbic afferents and
dopaminergic input from the ventral tegmental area converge onto common
dendrites of the me...
Polymorphisms in the Taste Receptor Gene (Tas1r3) Region Are Associated with Saccharin Preference in 30 Mouse Strains
Journal of Neuroscience - Tập 24 Số 4 - Trang 938-946 - 2004
The results of recent studies suggest that the mouseSac(saccharin preference)
locus is identical to theTas1r3(taste receptor) gene. The goal of this study was
to identifyTas1r3sequence variants associated with saccharin preference in a
large number of inbred mouse strains. Initially, we sequenced ∼6.7 kb of
theTas1r3gene and its flanking regions from six inbred mouse strains with high
and low sacc...
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
Journal of Neuroscience - Tập 22 Số 3 - Trang 1063-1071 - 2002
Autoradiographic localization of adenosine receptors in rat brain using [3H]cyclohexyladenosine
Journal of Neuroscience - Tập 2 Số 9 - Trang 1230-1241 - 1982
Adenosine (A1) receptor binding sites have been localized in rat brain by an in
vitro light microscopic autoradiographic method. The binding of
[3H]N6-cyclohexyladenosine to slide-mounted rat brain tissue sections has the
characteristics of A1 receptors. It is saturable with high affinity and has
appropriate pharmacology and stereospecificity. The highest densities of
adenosine receptors occur in ...
High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system
Journal of Neuroscience - Tập 14 Số 5 - Trang 3059-3071 - 1994
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene that is
mutated in human familial adenomatous polyposis, an autosomal dominant condition
with predisposition to colorectal carcinoma and brain tumors. Although tumor
suppressor genes appear to play a general role in regulating cellular
proliferation, the normal biological function of the APC gene product is
unknown. In the presen...
Auditory Cortical Neurons Respond to Somatosensory Stimulation
Journal of Neuroscience - Tập 23 Số 20 - Trang 7510-7515 - 2003
The prevailing hierarchical model of cortical sensory processing holds that
early processing is specific to individual modalities and that combination of
information from different modalities is deferred until higher-order stages of
processing. In this paper, we present physiological evidence of multisensory
convergence at an early stage of cortical auditory processing. We used
multi-neuron cluste...
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