Journal of Neuroscience

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Interaction of Genetic and Environmental Factors in aDrosophilaParkinsonism Model
Journal of Neuroscience - Tập 27 Số 10 - Trang 2457-2467 - 2007
Anathbandhu Chaudhuri, Kevin M. Bowling, Christopher D. Funderburk, Hakeem O. Lawal, Arati A. Inamdar, Zhe Wang, Janis M. O’Donnell
Catastrophic loss of dopaminergic neurons is a hallmark of Parkinson's disease. Despite the recent identification of genes associated with familial parkinsonism, the etiology of most Parkinson's disease cases is not understood. Environmental toxins, such as the herbicide paraquat, appear to be risk factors, and it has been proposed that susceptibility is influenced by genetic background. T...... hiện toàn bộ
Coincident Activation of NMDA and Dopamine D1Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning
Journal of Neuroscience - Tập 20 Số 20 - Trang 7737-7742 - 2000
Stephanie L. Smith‐Roe, Ann E. Kelley
The nucleus accumbens, a brain structure ideally situated to act as an interface between corticolimbic information-processing regions and motor output systems, is well known to subserve behaviors governed by natural reinforcers. In the accumbens core, glutamatergic input from its corticolimbic afferents and dopaminergic input from the ventral tegmental area converge onto common dendrites o...... hiện toàn bộ
Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex
Journal of Neuroscience - Tập 22 Số 3 - Trang 1063-1071 - 2002
Anne E. Baldwin, Ken Sadeghian, Ann E. Kelley
High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system
Journal of Neuroscience - Tập 14 Số 5 - Trang 3059-3071 - 1994
Ratan V. Bhat, Jay M. Baraban, RC Johnson, Betty Eipper, Richard E. Mains
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene that is mutated in human familial adenomatous polyposis, an autosomal dominant condition with predisposition to colorectal carcinoma and brain tumors. Although tumor suppressor genes appear to play a general role in regulating cellular proliferation, the normal biological function of the APC gene product is unknown. In th...... hiện toàn bộ
Distribution of Corticosteroid Receptors in the Rhesus Brain: Relative Absence of Glucocorticoid Receptors in the Hippocampal Formation
Journal of Neuroscience - Tập 20 Số 12 - Trang 4657-4668 - 2000
Mar M. Sánchez, Larry J. Young, Paul M. Plotsky, Thomas R. Insel
Chronic stress has been associated with degenerative changes in the rodent and primate hippocampus, presumably mediated in part via neuronal glucocorticoid receptors (GRs). In the rat brain, GRs are widely distributed and are particularly dense in the hippocampus. The distribution of GRs in the primate brain, however, has not been fully characterized. In this study, we usedin ...... hiện toàn bộ
The State of the NIH BRAIN Initiative
Journal of Neuroscience - Tập 38 Số 29 - Trang 6427-6438 - 2018
Walter J. Koroshetz, Joshua A. Gordon, Alois J. Adams, Andrea Beckel‐Mitchener, James D. Churchill, Gregory K. Farber, Michelle Freund, Jim Gnadt, Nina S. Hsu, Nicholas B. Langhals, Sarah H. Lisanby, Бо Лю, Grace C. Y. Peng, Khara M. Ramos, Michael A. Steinmetz, Edmund M. Talley, Samantha White
Somatostatin Modulates Voltage-Gated K+and Ca2+Currents in Rod and Cone Photoreceptors of the Salamander Retina
Journal of Neuroscience - Tập 20 Số 3 - Trang 929-936 - 2000
Abram Akopian, Juliette Johnson, Róbert Gábriel, Nicholas C. Brecha, Paul Witkovsky
We investigated the cellular localization in the salamander retina of one of the somatostatin [or somatotropin release-inhibiting factor (SRIF)] receptors, sst2A, and studied the modulatory action of SRIF on voltage-gated K+and Ca2+currents in rod and cone photoreceptors. SRIF immunostaining was observed in widely spaced amacri...... hiện toàn bộ
Vasotocin and Mesotocin Stimulate the Biosynthesis of Neurosteroids in the Frog Brain
Journal of Neuroscience - Tập 26 Số 25 - Trang 6749-6760 - 2006
Jean-Claude do-Rego, Samik Acharjee, Jae Young Seong, Ludovic Galas, Aurélie Drouet, Patrice Bizet, A Burlet, Hyeok-Bin Kwon, Van Luu-Thé, G. Pelletier, Hubert Vaudry
Mechanisms of NMDA Receptor- and Voltage-Gated L-Type Calcium Channel-Dependent Hippocampal LTP Critically Rely on Proteolysis That Is Mediated by Distinct Metalloproteinases
Journal of Neuroscience - Tập 37 Số 5 - Trang 1240-1256 - 2017
Grzegorz Wiera, Daria Nowak, Inge Van Hove, Piotr Dzięgiel, Lieve Moons, Jerzy W. Mozrzymas
Long-term potentiation (LTP) is widely perceived as a memory substrate and in the hippocampal CA3-CA1 pathway, distinct forms of LTP depend on NMDA receptors (nmdaLTP) or L-type voltage-gated calcium channels (vdccLTP). LTP is also known to be effectively regulated by extracellular proteolysis that is mediated by various enzymes. Herein, we investigated whether in mice hippocampal slices t...... hiện toàn bộ
An immunohistochemical study of the nerve growth factor receptor in developing rats
Journal of Neuroscience - Tập 8 Số 9 - Trang 3481-3498 - 1988
Yan Qiao, E. Marshall Johnson
Nerve growth factor (NGF) receptor expression was studied in rats between embryonic day 11 (E11) to postnatal day 10 (PND10) by using a monoclonal antibody, 192-IgG, that specifically recognizes rat NGF receptor. Sympathetic ganglia were lightly stained by 192-IgG for NGF receptor immunoreactivity (NGFRI) (E11-PND10). Neural crest-derived sensory ganglia were moderately to densely stained ...... hiện toàn bộ
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