Journal of Neuroimmune Pharmacology

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Alcohol-Induced Interactive Phosphorylation of Src and Toll-like Receptor Regulates the Secretion of Inflammatory Mediators by Human Astrocytes
Journal of Neuroimmune Pharmacology - Tập 5 - Trang 533-545 - 2010
Nicholas A. Floreani, Travis J. Rump, P. M. Abdul Muneer, Saleena Alikunju, Brenda M. Morsey, Michael R. Brodie, Yuri Persidsky, James Haorah
Secretion of pro-inflammatory molecules by astrocytes after alcohol treatment was shown to be associated with neuroinflammation. We hypothesized that activation of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX-2) by ethanol in astrocytes enhanced the secretion of inflammatory agents via the interactive tyrosine phosphorylation of toll-like receptor 4 (TLR4) and Src kinase. To test thi...... hiện toàn bộ
Endocytic Trafficking of HIV gp120 is Mediated by Dynamin and Plays a Role in gp120 Neurotoxicity
Journal of Neuroimmune Pharmacology - Tập 12 - Trang 492-503 - 2017
Erin D. Wenzel, Alessia Bachis, Valeria Avdoshina, Francesca Taraballi, Ennio Tasciotti, Italo Mocchetti
Neurons that endocytose the human immunodeficiency virus-1 (HIV) protein gp120 exhibit neurite retraction and activation of caspase-3, suggesting that the endocytic process may be crucial for gp120-mediated neuronal injury. The goal of this study is to demonstrate that internalization and accumulation of gp120 play a role in its neurotoxic effects. In mammalian cells, endocytosis is primarily a dy...... hiện toàn bộ
Advances in Targeted Drug Delivery Approaches for the Central Nervous System Tumors: The Inspiration of Nanobiotechnology
Journal of Neuroimmune Pharmacology - Tập 12 - Trang 84-98 - 2016
Jianing Meng, Vivek Agrahari, Ibrahima Youm
At present, brain tumor is among the most challenging diseases to treat and the therapy is limited by the lack of effective methods to deliver anticancer agents across the blood-brain barrier (BBB). BBB is a selective barrier that separates the circulating blood from the brain extracellular fluid. In its neuroprotective function, BBB prevents the entry of toxins, as well as most of anticancer agen...... hiện toàn bộ
Mutation of Tyrosine 470 of Human Dopamine Transporter is Critical for HIV-1 Tat-Induced Inhibition of Dopamine Transport and Transporter Conformational Transitions
Journal of Neuroimmune Pharmacology - Tập 8 Số 4 - Trang 975-987 - 2013
Narasimha M. Midde, Xiaoqin Huang, Adrian M. Gomez, Rosemarie M. Booze, Chang‐Guo Zhan, Jun Zhu
Host and Viral Factors Influencing the Pathogenesis of HIV-Associated Neurocognitive Disorders
Journal of Neuroimmune Pharmacology - Tập 4 Số 2 - Trang 175-189 - 2009
Suman Jayadev, Gwenn A. Garden
Intrathecal Administration of an Anti‐nociceptive Non-CpG Oligodeoxynucleotide Reduces Glial Activation and Central Sensitization
Journal of Neuroimmune Pharmacology - Tập 16 - Trang 818-834 - 2021
C. Leiguarda, A. Villarreal, C. Potilinski, T. Pelissier, M. F. Coronel, J. Bayo, A. J. Ramos, A. Montaner, M. J. Villar, L. Constandil, Pablo R. Brumovsky
Inflammatory pain associates with spinal glial activation and central sensitization. Systemic administration of IMT504, a non-CpG oligodeoxynucleotide originally designed as an immunomodulator, exerts remarkable anti-allodynic effects in rats with complete Freund´s adjuvant (CFA)-induced hindpaw inflammation. However, the anti-nociceptive mechanisms of IMT504 remain unknown. Here we evaluated whet...... hiện toàn bộ
Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson’s Disease
Journal of Neuroimmune Pharmacology - - 2021
Nidheesh Thadathil, Jianfeng Xiao, Roderick Hori, Stephen E. Alway, Mohammad Moshahid Khan
From Initiation to Maintenance: HIV-1 Gp120-induced Neuropathic Pain Exhibits Different Molecular Mechanisms in the Mouse Spinal Cord Via Bioinformatics Analysis Based on RNA Sequencing
Journal of Neuroimmune Pharmacology - - 2022
Huang Jian, Fei Lin, Yanling Hu, Chris Bloe Bloe, Dan Wang, Wenping Zhang
Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke
Journal of Neuroimmune Pharmacology - Tập 4 - Trang 249-259 - 2009
Ming Zhang, Billy R. Martin, Martin W. Adler, Raj J. Razdan, Weimin Kong, Doina Ganea, Ronald F. Tuma
Recognition of the importance of the endocannabinoid system in both homeostasis and pathologic responses raised interest recently in the development of therapeutic agents based on this system. The CB2 receptor, a component of the endocannabinoid system, has significant influence on immune function and inflammatory responses. Inflammatory responses are major contributors to central nervous system (...... hiện toàn bộ
Adrenergic Modulation of Hematopoiesis
Journal of Neuroimmune Pharmacology - Tập 15 - Trang 82-92 - 2019
Georges J. M. Maestroni
Hematopoiesis produce every day billions of blood cells and takes place in the bone marrow (BM) by the proliferation and differentiation of hematopoietic stem cells (HSC). HSC are found mainly adjacent to the BM vascular sinusoids where endothelial cells and mesenchimal stromal cells promote HSC maintenance by producing a variety of factors. Other cell types that regulate HSC niches include sympat...... hiện toàn bộ
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