Journal of Neuroimmune Pharmacology
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Prediction of Schizophrenia Diagnosis by Integration of Genetically Correlated Conditions and Traits
Journal of Neuroimmune Pharmacology - Tập 13 - Trang 532-540 - 2018
Schizophrenia is genetically heterogeneous and comorbid with many conditions. In this study, we explored polygenic scores (PGSs) from genetically related conditions and traits to predict schizophrenia diagnosis using both logistic regression and deep neural network (DNN) models. We used the combined Molecular Genetics of Schizophrenia and Swedish Schizophrenia Case Control Study (MGS + SSCCS) data...... hiện toàn bộ
Anti-JCV Antibodies Detection and JCV DNA Levels in PBMC, Serum and Urine in a Cohort of Spanish Multiple Sclerosis Patients Treated with Natalizumab
Journal of Neuroimmune Pharmacology - Tập 8 - Trang 1277-1286 - 2013
One of the most effective multiple sclerosis (MS) treatment is natalizumab. Nevertheless, it has been associated with an increased risk of progressive multifocal leukoencephalopathy (PML) caused by the JC virus (JCV). Our main objective was to assess the utility of testing JCV-DNA, apart from anti-JCV antibodies, to determine which natalizumab-treated MS patients has been previously in contact wit...... hiện toàn bộ
Impact of Adolescent Nicotine Exposure in Pre- and Post-natal Oxycodone Exposed Offspring
Journal of Neuroimmune Pharmacology - Tập 18 - Trang 413-426 - 2023
Perinatal exposure to prescription opioids pose a critical public health risk. Notably, research has found significant neurodevelopmental and behavioral deficits between in utero (IUO) and postnatal (PNO) oxycodone-exposed offspring but there is a notable gap in knowledge regarding the interaction of these groups to other drug exposure, particularly nicotine exposure. Nicotine’s widespread use rep...... hiện toàn bộ
Methamphetamine Enhances HIV-1 Infectivity in Monocyte Derived Dendritic Cells
Journal of Neuroimmune Pharmacology - Tập 4 - Trang 129-139 - 2008
The US is currently experiencing an epidemic of methamphetamine (Meth) use as a recreational drug. Recent studies also show a high prevalence of HIV-1 infection among Meth users. We report that Meth enhances HIV-1 infectivity of dendritic cells as measured by multinuclear activation of a galactosidase indicator (MAGI) cell assay, p24 assay, and LTR-RU5 amplification. Meth induces increased HIV-1 i...... hiện toàn bộ
Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse
Journal of Neuroimmune Pharmacology - Tập 13 - Trang 355-370 - 2018
We previously showed that autophagy is an important component in human immunodeficiency virus (HIV) replication and in the combined morphine-induced neuroinflammation in human astrocytes and microglia. Here we further studied the consequences of autophagy using glial cells of mice partially lacking the essential autophagy gene Atg6 (Beclin1) exposed to HIV Tat and morphine. Tat is known to cause a...... hiện toàn bộ
Yin and Yang of PDGF-mediated Signaling Pathway in the Context of HIV Infection and Drug Abuse
Journal of Neuroimmune Pharmacology - - 2014
Orphanin FQ/Nociceptin Activates Nuclear Factor Kappa B
Journal of Neuroimmune Pharmacology - Tập 6 - Trang 617-625 - 2011
Endogenous neuropeptide orphanin FQ/nociceptin (OFQ/N) and its receptor, nociceptin orphanin FQ peptide receptor (NOPr), play a modulatory role throughout the body including nociceptive sensitivity, motor function, spatial learning, and the immune system. NOPr is an inhibitory G protein coupled receptor (GPCR) that modulates expression and release of inflammatory mediators from immune cells and in...... hiện toàn bộ
The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells
Journal of Neuroimmune Pharmacology - Tập 14 - Trang 94-109 - 2018
We have developed models of HIV latency using microglia derived from adult human patient brain cortex and transformed with the SV40 T large and hTERT antigens. Latent clones infected by HIV reporter viruses display high levels of spontaneous HIV reactivation in culture. BrainPhys, a medium highly representative of the CNS extracellular environment, containing low glucose and 1% FBS, reduced, but d...... hiện toàn bộ
The Journal of Neuroimmune Pharmacology Reaches Its Stride
Journal of Neuroimmune Pharmacology - Tập 2 - Trang 129-130 - 2007
Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis
Journal of Neuroimmune Pharmacology - Tập 12 - Trang 693-707 - 2017
Extracellular high mobility group box 1 (HMGB1) activates the receptor for advanced glycation end products (RAGE) or Toll-like receptor 4 (TLR4) and forms a heterocomplex with CXCL12 that strongly activates CXCR4, promoting inflammatory and pain signals. In the present study, we investigated the role of HMGB1 in pancreatic pain accompanying cerulein-induced acute pancreatitis in mice. Abdominal re...... hiện toàn bộ
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