Journal of Neuroimmune Pharmacology

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Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats
Journal of Neuroimmune Pharmacology - Tập 12 Số 2 - Trang 277-291 - 2017
Sally A. Abuelezz, Nevien Hendawy, Yosra Magdy
Alcohol-Induced Interactive Phosphorylation of Src and Toll-like Receptor Regulates the Secretion of Inflammatory Mediators by Human Astrocytes
Journal of Neuroimmune Pharmacology - Tập 5 - Trang 533-545 - 2010
Nicholas A. Floreani, Travis J. Rump, P. M. Abdul Muneer, Saleena Alikunju, Brenda M. Morsey, Michael R. Brodie, Yuri Persidsky, James Haorah
Secretion of pro-inflammatory molecules by astrocytes after alcohol treatment was shown to be associated with neuroinflammation. We hypothesized that activation of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX-2) by ethanol in astrocytes enhanced the secretion of inflammatory agents via the interactive tyrosine phosphorylation of toll-like receptor 4 (TLR4) and Src kinase. To test thi...... hiện toàn bộ
STING/NF-κB/IL-6-Mediated Inflammation in Microglia Contributes to Spared Nerve Injury (SNI)-Induced Pain Initiation
Journal of Neuroimmune Pharmacology - Tập 17 - Trang 453-469 - 2021
Jia Sun, Ya-qun Zhou, Bing-yang Xu, Jia-yan Li, Long-qing Zhang, Dan-yang Li, Shuang Zhang, Jia-yi Wu, Shao-jie Gao, Da-wei Ye, Wei Mei
Innate immune response acts as the first line of host defense against damage and is initiated following the recognition of pathogen-associated molecular patterns (PAMPs). For double-stranded DNA (dsDNA) sensing, interferon gene stimulator (STING) was discovered to be an integral sensor and could mediate the immune and inflammatory response. Selective STING antagonist C-176 was administered and pai...... hiện toàn bộ
Effect of Morphine on the Neuropathogenesis of SIVmac Infection in Indian Rhesus Macaques
Journal of Neuroimmune Pharmacology - Tập 3 - Trang 12-25 - 2007
Joanne K. Marcario, Mariam Riazi, Istvan Adany, Himanshu Kenjale, Kandace Fleming, Janet Marquis, Olga Nemon, Matthew S. Mayo, Thomas Yankee, Opendra Narayan, Paul D. Cheney
Morphine is known to prevent the development of cell-mediated immune (CMI) responses and enhance expression of the CCR5 receptor in monocyte macrophages. We undertook a study to determine the effect of morphine on the neuropathogenesis and immunopathogenesis of simian immunodeficiency virus (SIV) infection in Indian Rhesus Macaques. Hypothetically, the effect of morphine would be to prevent the de...... hiện toàn bộ
The Molecular Basis for Neuroimmune Receptor Signaling
Journal of Neuroimmune Pharmacology - Tập 7 - Trang 722-724 - 2012
Thomas J. Rogers
Many of the receptors which are responsible for the responses to the common drugs of abuse belong to the G protein-coupled receptor (GPCR) family. In this special issue of the Journal of Neuroimmune Pharmacology a collection of papers is presented which deals with signaling events that are important for the function of these receptors. Because these receptors are expressed by both neuronal and imm...... hiện toàn bộ
Suppression of CCL2/MCP-1 and CCL5/RANTES Expression by Nociceptin in Human Monocytes
Journal of Neuroimmune Pharmacology - Tập 3 - Trang 75-82 - 2007
David E. Kaminsky, Thomas J. Rogers
The receptor designated Opioid Receptor-Like 1 (ORL1) is abundantly expressed in the central nervous system (CNS) as well as by cells of the immune system. While much is known about the function of ORL1 in the CNS, there is little information in the literature about the role of ORL1 in the immune response. There have been numerous reports documenting the effects of GPCR activation on the expressio...... hiện toàn bộ
Effect of Fingolimod-Treatment on Blood Lipid Profiles of Multiple Sclerosis Patients
Journal of Neuroimmune Pharmacology - Tập 11 - Trang 611-612 - 2016
Anni Hovi, Laura Airas
Phenotype of Antigen Unexperienced TH Cells in the Inflamed Central Nervous System in Experimental Autoimmune Encephalomyelitis
Journal of Neuroimmune Pharmacology - Tập 12 - Trang 305-313 - 2016
Sophia Franck, Magdalena Paterka, Jerome Birkenstock, Frauke Zipp, Volker Siffrin, Esther Witsch
Multiple sclerosis is a chronic, disseminated inflammation of the central nervous system which is thought to be driven by autoimmune T cells. Genetic association studies in multiple sclerosis and a large number of studies in the animal model of the disease support a role for effector/memory T helper cells. However, the mechanisms underlying relapses, remission and chronic progression in multiple s...... hiện toàn bộ
The COVID-19 Pandemic: Reflections of Science, Person, and Challenge in Academic Research Settings
Journal of Neuroimmune Pharmacology - Tập 16 - Trang 706-717 - 2021
Jean M. Bidlack, Sulie L. Chang, Sylvia Fitting, Howard E. Gendelman, Santhi Gorantla, Santosh Kumar, Maria Cecilia Garibaldi Marcondes, Douglas D. Meigs, Loyda M. Melendez, Ilker K. Sariyer, Sowmya Yelamanchili
In spring of 2021, the Society on NeuroImmune Pharmacology (SNIP) organized a virtual workshop on the coronavirus disease 2019 (COVID-19). The daylong event’s fourth and final symposium, “Well-being and reflections,” offered a glimpse at the pandemic’s impact on the lives of our scientists and educators. This manuscript includes a brief summary of the symposium, a transcription of our incoming pre...... hiện toàn bộ
Drug Induced Increases in CNS Dopamine Alter Monocyte, Macrophage and T Cell Functions: Implications for HAND
Journal of Neuroimmune Pharmacology - Tập 8 Số 3 - Trang 621-642 - 2013
Peter J. Gaskill, Tina M. Calderon, Jacqueline S. Coley, Joan W. Berman
Tổng số: 730   
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