The Molecular Basis for Neuroimmune Receptor Signaling
Tóm tắt
Many of the receptors which are responsible for the responses to the common drugs of abuse belong to the G protein-coupled receptor (GPCR) family. In this special issue of the Journal of Neuroimmune Pharmacology a collection of papers is presented which deals with signaling events that are important for the function of these receptors. Because these receptors are expressed by both neuronal and immune cells, and because these receptors play a complex role in regulating function in both the nervous and immune systems, a more complete understanding of the regulation of expression of these receptors is essential. Moreover, once these receptors are expressed and activated, a complex series of signaling events are initiated that can have substantial significance. We have only a limited understanding of these signaling events, but with more complete information, we may be able to control the undesirable and/or desirable consequences of receptor activation by drugs of abuse.
Tài liệu tham khảo
Hwang CK, Wagley Y, Law P-Y, Wei L-N, Loh HH (2012) MicroRNAs in opioid pharmacology. J Neuroimmune Pharmacol. doi:10.1007/s11481-011-9323-2
Karmaus PWF, Chen W, Kaplan BLF, Kaminski NE (2012) Δ9-Tetrahydrocannabinol suppresses cytotoxic t lymphocyte function independent of CB1 and CB2, disrupting early activation events. J Neuroimmune Pharmacol. doi:10.1007/s11481-011-9293-4
Mithal DS, Banisadr G, Miller RJ (2012) CXCL12 Signaling in the development of the nervous system. J Neuroimmune Pharmacol. doi:10.1007/s11481-011-9336-x
Panas MW, Xie Z, Panas HN, Hoener MC, Vallender EJ, Miller GM (2011) Trace amine associated receptor 1 signaling in activated lymphocytes. J Neuroimmune Pharmacol. doi:10.1007/s11481-011-9321-4
Podhaizer EM, Zou S , Fitting S, Samano KL, El-Hage N, Knapp PE, Hauser KF (2011) Morphine and gp120 toxic interactions in striatal neurons are dependent on HIV-1 strain. J Neuroimmune Pharmacol. doi:10.1007/s11481-011-9326-z
Sharir H, Console-Bram L, Mundy C, Popoff SN, Kapur A, Abood ME (2012) The endocannabinoids anandamide and virodhamine modulate the activity of the candidate cannabinoid receptor GPR55. J Neuroimmune Pharmacol. doi:10.1007/s11481-012-9351-6
Zhang L, Belkowski JS, Briscoe T, Rogers TJ (2012) Regulation of Mu opioid receptor expression in developing T cells. J Neuroimmune Pharmacol (in this issue)