Acrolein contributes to TRPA1 up‐regulation in peripheral and central sensory hypersensitivity following spinal cord injuryJournal of Neurochemistry - Tập 135 Số 5 - Trang 987-997 - 2015
Jonghyuck Park, Lingxing Zheng, Glen Acosta, Sasha Vega‐Alvarez, Zhe Chen, Breanne Muratori, Peng Cao, Riyi Shi
AbstractAcrolein, an endogenous aldehyde, has been shown to be involved in sensory hypersensitivity after rat spinal cord injury (SCI), for which the pathogenesis is unclear. Acrolein can directly activate a pro‐algesic transient receptor protein ankyrin 1 (... hiện toàn bộ
Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injuryJournal of Neurochemistry - Tập 138 Số 2 - Trang 328-338 - 2016
Zhe Chen, Jonghyuck Park, Breanne Butler, Glen Acosta, Sasha Vega‐Alvarez, Lingxing Zheng, Jonathan Tang, Robyn McCain, Wenpeng Zhang, Zheng Ouyang, Peng Cao, Riyi Shi
AbstractCurrently there are no effective therapies available for the excruciating neuropathic pain that develops after spinal cord injuries (SCI). As such, a great deal of effort is being put into the investigation of novel therapeutic targets that can alleviate this pain. One such target is ac...... hiện toàn bộ
Interleukin‐10 provides direct trophic support to neuronsJournal of Neurochemistry - Tập 110 Số 5 - Trang 1617-1627 - 2009
Zixuan Zhou, Xiangmin Peng, Ryan Insolera, David J. Fink, Marina Mata
AbstractInterleukin (IL)‐10, a prototypical anti‐inflammatory cytokine, has been shown to provide beneficial effects in neuronal injuryin vivobut the full range of actions has not been established. In order to understand the neuronal mechanisms underlying IL‐10‐mediated neuroprotection, we examined the effect of IL‐10 on primary neurons i...... hiện toàn bộ
Acrolein involvement in sensory and behavioral hypersensitivity following spinal cord injury in the ratJournal of Neurochemistry - Tập 128 Số 5 - Trang 776-786 - 2014
Michael R. Due, Jonghyuck Park, Lingxing Zheng, Michael Walls, Yohance M. Allette, Fletcher A. White, Riyi Shi
AbstractGrowing evidence suggests that oxidative stress, as associated with spinal cord injury (SCI), may play a critical role in both neuroinflammation and neuropathic pain conditions. The production of the endogenous aldehyde acrolein, following lipid peroxidation during the inflammatory response, may ...... hiện toàn bộ
Somatostatin receptors (sst2) are coupled to Go and modulate GTPase activity in the rabbit retinaJournal of Neurochemistry - Tập 84 Số 4 - Trang 625-632 - 2003
Anna Vasilaki, Zafiroula Georgoussi, Kyriaki Thermos
AbstractThe role of somatostatin and its mechanism of action in the retina remains an important target for investigation. Biochemical and pharmacological studies were engaged to characterize the somatostatin receptors in the rabbit retina, and their coupling to G‐proteins. The ability of selective ligands to inhibit [125I]Tyr11‐somatostatin‐14 ...... hiện toàn bộ