Role of oxidative stress in paraquat‐induced dopaminergic cell degenerationJournal of Neurochemistry - Tập 93 Số 4 - Trang 1030-1037 - 2005
Alison L. McCormack, Jennifer G Atienza, Louisa C. Johnston, Julie K. Andersen, Susan Vu, Donato A. Di Monte
AbstractSystemic treatment of mice with the herbicide paraquat causes the selective loss of nigrostriatal dopaminergic neurons, reproducing the primary neurodegenerative feature of Parkinson's disease. To elucidate the role of oxidative damage in paraquat neurotoxicity, the time‐course of neurodegeneration was correlated to changes in 4‐hydroxy‐2‐nonenal (4‐HNE), a...... hiện toàn bộ
Molecular Cloning and Regional Distribution of a Human Proton Receptor Subunit with Biphasic Functional PropertiesJournal of Neurochemistry - Tập 72 Số 1 - Trang 51-57 - 1999
K. Babinski, Khanh-Tuoc Lê, Philippe Séguéla
Abstract : Small changes of extracellular pH activate depolarizing
inward currents in most nociceptive neurons. It has been recently proposed
that acid sensitivity of sensory as well as central neurons is mediated by a
family of proton‐gated cation channels structurally related to
Caenorhabditis elegans degenerins and mammalian epithelial s...... hiện toàn bộ
Presynaptic Adenosine A2 and N‐Methyl‐D‐Aspartate Receptors Regulate Dopamine Synthesis in Rat Striatal SynaptosomesJournal of Neurochemistry - Tập 56 Số 5 - Trang 1783-1788 - 1991
Muhammad Abdul Baker Chowdhury, Marianne Fillenz
Abstract: Dopamine synthesis rate and cyclic AMP concentration were measured in synaptosomes prepared from rat striatum. Dopamine synthesis rate was decreased by the addition of either adenosine deaminase or 8‐phenyltheophylline, an adenosine receptor blocker, and was increased by the addition of 2‐chloroadenosine. The addition of L‐glutamate in the absence of adeno...... hiện toàn bộ
Tissue Distribution of Human Monoamine Oxidase A and B mRNAJournal of Neurochemistry - Tập 55 Số 4 - Trang 1166-1169 - 1990
Joseph Grimsby, Nancy C. Lan, Rachael L. Neve, Kevin Chen, Jean C. Shih
Abstract: Monoamine oxidase (MAO) A and B play important roles in the metabolism of biogenic amines. Northern analysis using 32P‐labeled subfragments of human liver MAO A and B cDNA clones detected a 5‐ and a 3‐kb transcript, respectively, in most human tissues examined. However, fetal heart and thymus express minute amounts of MAO A transcript,...... hiện toàn bộ