Journal of Neurochemistry

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Functional Characterization of the Murine Serotonin Transporter Gene Promoter in Serotonergic Raphe Neurons
Journal of Neurochemistry - Tập 70 Số 3 - Trang 932-939 - 1998
Armin Heils, Christine H. Wichems, Claudia Sommer, Susanne Petri, Katharina Glatz, Dietmar Bengel, Dennis L. Murphy, Klaus‐Peter Lesch
Abstract: We have isolated and characterized the 5′‐flanking regulatory region of the murine serotonin 5‐HT transporter (5‐HTT) gene. A TATA‐like motif and several potential binding sites for transcription factors, including two AP1, several AP2 and AP4 binding sites, CCAAT and GC boxes (SP1 binding sites), a nuclear factor‐κB, and a cyclic AMP response element‐like ...... hiện toàn bộ
Ammonia Intoxication: Effects on Cerebral Cortex and Spinal Cord
Journal of Neurochemistry - Tập 44 Số 4 - Trang 1252-1258 - 1985
Sping Lin, W. Raabe
Abstract: The effect of an acute systemic ammonia intoxication on the metabolic states of the cerebral cortex and the spinal cord of the same animal was studied in the cat. The intravenous infusion of ammonium acetate (2 and 4 mmol/kg body weight/30 min) increased the gross levels of tissue NH4, glutamine, glutamine/glutamate ratio, lactate, and...... hiện toàn bộ
Depolarisation‐Dependent Protein Phosphorylation in Rat Cortical Synaptosomes: Factors Determining the Magnitude of the Response
Journal of Neurochemistry - Tập 41 Số 4 - Trang 909-918 - 1983
Phillip J. Robinson, Peter R. Dunkley
Abstract: The sequence of molecular events linking depolarisation‐dependent calcium influx to the release of neurotransmitters from nerve terminals is unknown; however, calcium‐stimulated protein phosphorylation may play a role. In this study the incorporation of phosphate into proteins was investigated using an intact postmitochondrial pellet isolated from rat cere...... hiện toàn bộ
Neuronal c‐Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N‐terminus are moderate
Journal of Neurochemistry - Tập 121 Số 4 - Trang 607-618 - 2012
Crystal A. Ruff, Nils Holger Staak, Smriti Patodia, Mark Kaswich, Eridan Rocha‐Ferreira, Clive Da Costa, Stephan Brecht, Milan Makwana, Xavier Fontana, Mariya Hristova, Prakasham Rumajogee, Matthias Galiano, Marion Bohatschek, Thomas Herdegen, Axel Behrens, Gennadij Raivich
J. Neurochem. (2012) 121, 607–618.AbstractAlthough neural c‐Jun is essential for successful peripheral nerve regeneration, the cellular basis of this effect and the impact of c‐Jun activation are incompletely understood. In the current study, we explored ...... hiện toàn bộ
Excessive hippocampal acetylcholine levels in acetylcholinesterase‐deficient mice are moderated by butyrylcholinesterase activity
Journal of Neurochemistry - Tập 100 Số 5 - Trang 1421-1429 - 2007
Joachim Hartmann, Cornelia Kiewert, Ellen G. Duysen, Oksana Lockridge, Nigel H. Greig, Jochen Klein
AbstractCentral cholinergic systems are involved in a plethora of brain functions and are severely and selectively damaged in neurodegenerative diseases such as Alzheimer’s disease and dementia with Lewy bodies. Cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic func...... hiện toàn bộ
Differential Regulation of Neuronal Nicotinic Receptor Binding Sites Following Chronic Nicotine Administration
Journal of Neurochemistry - Tập 69 Số 5 - Trang 2216-2219 - 1997
Christopher M. Flores, Martha I. Dávila‐García, Yvonne M. Ulrich‐Lai, Kenneth J. Kellar
Abstract: Chronic nicotine administration to rats produces an increase in neuronal nicotinic receptors in the CNS. Moreover, the up‐regulated sites labeled by [3H]cytisine in cerebral cortex appear to be composed exclusively of α4 and β2 subunits. It is unknown whether receptor subtypes that do not bind [3H]‐cytisine with hig...... hiện toàn bộ
Stimulation of lateral hypothalamic glutamate and acetylcholine efflux by nicotine: implications for mechanisms of nicotine‐induced activation of orexin neurons
Journal of Neurochemistry - Tập 113 Số 4 - Trang 1023-1035 - 2010
Ravi K. Pasumarthi, Jim R. Fadel
J. Neurochem. (2010) 113, 1023–1035.AbstractThe hypothalamus is a prominent target of nicotine action. We have previously shown that acute systemic nicotine treatment induces Fos expression in the lateral hypothalamus and perifornical area (LH/PFA), with...... hiện toàn bộ
Transfer of glutamine between astrocytes and neurons
Journal of Neurochemistry - Tập 77 Số 3 - Trang 705-719 - 2001
Stefan Bröer, Neville Brookes
The export of glutamine from astrocytes, and the uptake of glutamine by neurons, are integral steps in the glutamate‐glutamine cycle, a major pathway for the replenishment of neuronal glutamate. We review here the functional and molecular identification of the transporters that mediate this transfer. The emerging picture of glutamine transfer in adult brain is of a dominant pathway mediate...... hiện toàn bộ
CHOLINE ACETYLTRANSFERASE LEVELS IN DIENCEPHALIC NUCLEI OF THE RAT
Journal of Neurochemistry - Tập 24 Số 1 - Trang 35-38 - 1975
M. Brownstein, Ronald M. Kobayashi, Miklós Palkovits, Juan M. Saavedra
Abstract—Choline acetyltransferase levels have been measured in specific nuclei of the diencephalon. On the whole, the thalamic nuclei contain higher concentrations of this enzyme than do the hypothalamic and preoptic nuclei. Those nuclei which seem to receive the most dense cholinergic innervation contain the highest levels of choline acetyltransferase.
STANDARDIZATION OF A RADIOCHEMICAL ASSAY OF CHOLINE ACETYLTRANSFERASE AND A STUDY OF THE ACTIVATION OF THE ENZYME IN RABBIT BRAIN
Journal of Neurochemistry - Tập 18 Số 6 - Trang 935-941 - 1971
G. Bull, B Oderfeld-Nowak
Abstract— The standardization of a radiochemical assay of choline acetyltransferase (acetyl‐CoA: choline‐O‐acetyltransferase EC 2.3.1.6. [ChAc]) is described. The method depends upon the use of [l‐C14]acetyl‐CoA as substrate and has been modified from the procedure originally publish...... hiện toàn bộ
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